2004 Max Planck Research Prize for Martin Vingron and Eugene W. Myers
...gth. Using simulations, he was able to resolve the sequence overlaps for the entire human genome using only clones of defined length. This proved to be the key to the assembly of the complete genome. This year, the focus of the Max Planck Research Prize was modified to take particular account of the internati...Analysis uncovers critical stretches of human genome
... for proteins," said Haussler. When the rat genome sequence became available, the researchers decided to searc...ats and mice. Statistically, the likelihood that a sequence of this length would appear unchanged among all three genomes by chance was infinitesimally small. ...JGI decodes wood & toxic waste-degrading fungus genome
...day the publication of a high-quality draft genome sequence of the white rot fungus, Phanerochaete chrysospori... with similar chemical structures to lignin. The sequence findings are summarized in the May 2nd on-line edition of the journal Nature Biotechnology. "Phane...Kinase backgrounder: Iressa discovery part of major kinase project at Dana-Farber
...otides (specified as A, G, T, and C) is called the sequence of the gene, and it spells out a unique message th...ened to typographical errors, or big chunks of the sequence that are scrambled, deleted, or misplaced. Thanks to the just-completed Human Genome Project, the no...Kiratisin wins 2004 Dade MicroScan Young Investigator Award
...ed by using a technique known as housekeeping gene sequence analysis. Sequencing the glucose-6-phosphate dehyd... than either traditional biochemical techniques or sequence analysis of the 16S ribosomal DNA gene of these bacteria. Kiratisin concluded that ghd/gki gene s...Technique plucks rapidly evolving genes from a pathogen's genome
...hange within the genome. An organism's genome is a sequence of DNA nucleotides - either A, G, T or C (for aden...t in an arginine, leaving the protein's amino acid sequence unchanged. Based on the structure of the genetic code - that is, the translation table connecting co...Genetic sequence identified for anti-bacterial sea slug protein
...biologist Charles Derby has identified the genetic sequence of an anti-microbial protein called Escapin found in the ink of the common Aplysia sea slug or hare. The finding could have implications for the development of new anti-bacterial industrial compounds to prevent the formation of damaging biofilms on m......rnia eventually took part in the three-inoculation sequence over the next year; some 4,000 children alone at Franklin Sherman participated in the trials. "Volunteer support put the threat of polio behind us in 1954, just as volunteer support today is critical in the fight to address premature birth a...Hopkins scientists overcome main obstacle to making tons of short, drug-like proteins
...rchers would mix the pot with ribosomes and random sequence messenger RNAs that reflect the possible combinations of the 20 artificial amino acids for the desired length -- say, 10 blocks long. The ribosomes then churn away, making the peptides. To search for potential medicines, the peptide library would be...Genome-wide screen reveals new tricks of old genes
...vidence that proteins involved in checking the DNA sequence are also involved in keeping sister chromosomes together, and it's a great starting point for understanding more."...Researchers report definitive evidence that HIV-AIDS is not from oral polio vaccine
...e virus fell on the phylogenetic tree." Having the sequence of the new SIV's genetic material definitively shows that HIV-1 didn't come from chimpanzees in that area, he said. His next step is learning more about SIV from that region. "This is one of only a handful of places in the world where SIVs are known ...Annotation marathon validates 21,037 human genes
The announcement of the human genome sequence three years ago was widely hailed as one of the gr...d such an important part in the deciphering of the sequence itself. The consortium is made up of 152 scientists from developed as well as developing nations, in...Sick Kids researchers look at viral triggers for multiple sclerosis in children
...he immune system mounts a response to that genetic sequence in EBV, then sees it in myelin and targets it as w... Europe, and Australia. "We suspect that it is the sequence and timing of viral exposure and how this modifies an individual's immune response that is important...A fly (genome) like any other fly
... investigator on the project. The original genome sequence for Drosophila was published in 2000, reflecting a...w project will develop the necessary technology to sequence another 50 lines, capturing most of the natural variation in the species, Langley said. Eventually,...Evolution's mirror in a fish's spines
... . The researchers were able to determine the DNA sequence of the Pitx1 gene in marine fish with a normal hindfin and in freshwater fish with hindfin reduction. Although no changes were seen in the portions of the gene that code for the Pitx1 protein, comparative expression studies showed that the gene was...Decoding a sulfate-breathing bug
...is an expert on the organism. "Knowing the genomic sequence will allow detailed unraveling of the mechanism by... induced corrosion." In addition, the genome sequence by defining genes of interest in the process of metal ion reduction and metal ion precipitation is...Researchers identify unifying code among diverse classes of natural antibiotics
...ide signature, which integrates inverse amino acid sequence patterns and a hallmark 3-dimensional motif. This multidimensional signature is conserved in disulfide-stabilized antimicrobial peptides across biological kingdoms, and transcends motifs previously limited to defined peptide subclasses. Illustrating...Surprises found in gene variation associated with schizophrenia
...y a small minority of people with the variant gene sequence actually have schizophrenia. About one in 30 men with the particular polymorphism has the condition. Men are more likely than women to have this form of schizophrenia because the gene is X-chromosome linked. People with HOPA-linked schiz...Researchers make major gain in understanding how prions jump species
... to be highly restricted due to differences in the sequence of amino acids, the basic building blocks of each ...rkably, even though this new strain has amino acid sequence of protein A, it adopts the molecular shape and seeding specificity of protein from species C, and c...... protein fragments. HIV can, apparently, alter its sequence so that the human chopping proteins can no longer grab onto the viral protein. Cells infected with this mutant virus are not detected by the immune system, so the virus can replicate and increase in number. This was initially surprising, because t...