New Finding Suggests "HATs" Are Key To Gene Activation Puzzle
... paperpublished in Cell that they had cloned and sequenced a HAT; a later paper in Nature explained how theenzyme modifieshistones. The Rochester researchers were joined by Xiang-Jiao Yang, Tetsuro Kokubo, and Yoshihiro Nakatani at the NIH.Researchers at Cambridge University in England, Penn State, an...Researchers Find Production Point Of Key Protein In Fragile X Syndrome
...ip to mental retardation wasnot understood. It was sequenced and named the Fragile X Mental RetardationGene in 1991, but its mechanisms remained a mystery. The Fragile X Mental Retardation Gene is carried by mothers and passedon to sons. One in every 1,000 women is believed to carry the defectivegene; about o...E. Coli Genome Reported: Milestone Of Modern Biology Emerges From Wisconsin Lab
...been identified in the 4,639,221 base pairs of DNA sequenced by the Wisconsin team. Of these, one-third are of ...valescent diphtheria patient, the strainof E. coli sequenced by Blattner's team rose to prominence as an experimental organism in 1945 when it was used in the di...NIDR Supports Total Genome Studies Of Major Oral Pathogens
...future. The most recent organism to be completely sequenced is Helicobacterpylori, the bacterium that causes s...ach ulcers. Other notable organisms thathave been sequenced include the brewer's yeast Saccharomyces cerevisiae, thelaboratory workhorse and sometimes human pat......uring out the function of the genes that have been sequenced and applyingthat information in the clinic. Scientists may also find it easier to studyevolutionary relationships, how genes interact with each other and how genesinteract with the environment. What's most exciting to some scientists is thataccess to...Mouse Gene Reveals Clues To Human Deafness
...hearing. When the human form of the same gene was sequenced using DNAfrom hearing-impaired individuals in the Israeli family, a mutation was found ina critical part of the gene. Deaf members of the Israeli family carry two forms of the gene: onenormal and one mutant. Initially, the normal gene appears...Researchers Discover How Ulcer Bug Becomes Antibiotic-Resistant
... After the Dalhousie scientists cloned and sequenced rdxA, they and theirWashington University collaborators showed that this gene is responsible for resistance. First, the researchers found that the bacterium E. coli, whichnormally is metronidazole-resistant, became sensitive to the drug when theyinse...Perkin-Elmer, Dr. J. Craig Venter, And TIGR Announce Formation Of New Genomics Company
... constructed detailed genetic andphysical maps and sequenced approximately three percent of the three billionba...luding humans. In itsbrief history, TIGR has fully sequenced seven organisms. Most recently,TIGR released the DNA sequence for H. pylori , the bacteria that cau...Tiny Jamaican Tree Crab Made Big And Fast Evolutionary Leap, Scientists Discover
...nn State for genetic research inHedges's lab. "We sequenced two genes from each of these species, which gave usa little over a thousand base pairs--enough to say statistically that all theterrestrial Jamaican crabs form a single group," Hedges says. The genes used in the study have accumulated mutations at ...Genetic Study Reveals Sumatran Tigers Are A Distinct Species From All Mainland Tigers
...ve as a point ofcomparison. The mitochondrial DNA sequenced from the blood revealed thatSumatran tigers share three unique genetic markers found in none of the othertigers. These features support the interpretation that Sumatrans are a distinctspecies, and all other tiger populations on the mainland can be g...Gene Linked To Glaucoma, Hydrocephalus, And Other Birth Defects
...h sets of abnormalities When Hogan's group sequenced the mf1 gene from the ch mutant mice, theyfound that instead of producing the full protein, it stopped short, resulting inan incomplete protein that doesn't work properly. "We'd made our mutant by knocking out the gene completely, but natureh...Scientists Develop New Computer Program To Speed Determination Of Gene Function
...ulated the markers in all the genes that have been sequenced thus far sowe have a list of 13,000 to 14,0000 markers on our Web site; we basically aregiving them away to the world," he said. "We also put a server on the Web siteso that anyone can submit their own sequence, and the code will predict themarker an...Discovery Of Plant-Like Metabolic Pathway In Common Parasites Supplies New Targets For Therapy
...l utilized the shikimate pathway. Theyisolated and sequenced the genes for one of the shikimate pathway enzymes from Toxoplasma and a malaria parasite and demonstrated the presence of fourof the seven enzymes in parasites extracts. Finally, they tested glyphosate in mice infected with lethal doses of T.gondi...Syphilis Genome Sequence Offers Clues To Better Diagnosis, Prevention And Treatment
...r diagnostic tests and treatments, scientists have sequenced the completegenome for Treponema pallidum, the bacterium that causes syphilis. The project, funded by the National Institute of Allergy and Infectious Diseases(NIAID), was a collaboration between scientists led by George M. Weinstock,Ph.D., and Steve...Scientists Sequence Chlamydia Trachomatis Genome
...Ph.D., led the sequencing effort at Stanford. The sequenced genome has alreadybeen entered into a new on-line database, the STD Relational Database( http://www.stdgen.lanl.gov ), funded by NIAID and designed to accelerateresearch on STDs. "Their accomplishment has important implications for vaccine developm...DOE Joint Human Genome Effort Exceeds Sequencing Goal
...first full year of operation, the JGI successfully sequenced over 20million base pairs. Thanks to improved technologies, some developed by JGIresearchers, and streamlining techniques, the JGI has been able to reach ratesof over 2.5 million base pairs per month. According to Branscomb, the JGI'ssequencing goal ...Genetic Code Of Chromosome Of Malaria Parasite Deciphered
...NIH. Drs. Gardner, Hoffman and their collaborators sequenced chromosome 2 of P.falciparum. Theirs is the first report to describe the complete geneticsequence of a parasite chromosome. Project funding was initiated by the National Institute of Allergy andInfectious Diseases (NIAID) of NIH and the NIH Office o...Duke Study Finds More Genes May Be Affected By Toxic Cadmium
...e was previously unknown, even thoughall have been sequenced in the C. elegans genome project, Freedman said in hisinterview. In the article, Freedman hypothesized why some of the additional genesmight respond to cadmium exposure, but learning more will take more research, hesaid. "All we've done at...Software Helps Decipher Genomes Of Higher Organisms
... researchers from around the world have sent their sequenced DNA fragments via e-mail to Georgia Tech's GeneMark e-mail server, which predicts locations of genes. After mapping gene locations, the computer program compares the newly predicted protein sequence to known ones in a database. This determi...International Genome Team Deciphers Genetic Instructions For A Complete Animal
...United States and Great Britainannounced they have sequenced the animal's 97 million-base genome. It marks the...el human biology. Unlike the much smaller microbes sequenced so far, C. elegans begins life as asingle, fertilized cell and undergoes a series of cell divisions ...