Stanford researcher's findings may shed light on common, deadly birth defect
...exerts a waning but vital influence throughout the sequential construction of the brain and face. Blocking this protein's action at varying developmental stages yields very different anatomical results - including one in which only the exterior, or the face, is affected while the scaffolding, or the brain, is l...The telomere crisis: A crucial stage in breast cancer
...her causes. Partly the disagreement arises because sequential events can't be followed in individual tissue samples from living subjects. "In human studies, the order from normal ducts, to ductal hyperplasia, to ductal carcinoma in situ, to invasive cancer is just association," says Gray, "because we can't loo...Yale researchers receive $4.5 million grant to study spinal cord repair
... and preservation of neurological function, have a sequential overall structure - studies at the molecular/cellular level leading to studies in whole animal models, clinical trials and ultimately restoration of function in people with SCI and MS," said Waxman. During the past five years, over 40 medical and gra...New study confirms process leading to disorder causing male characteristics in women
...test this supposition, they employed a paradigm of sequential GnRH-receptor antagonist administration to suppress endogenous LH concentrations, and intermittent (pulse-like) infusions of physiological amounts of recombinant human LH (rhLH) to stimulate ovarian steroidogenesis. A New Study The authors of "Exag...Memory fails you after severe stress
... per cent from a photo-spread and 49 per cent from sequential photos- though the clothing cue boosted correct identification to 66 per cent (International Journal of Law and Psychiatry, vol 27, p 265). Thirty people got the gender wrong, and those subjected to physical threats were the worst at recognising thei...When combining new oral anti-cancer agents with standard chemotherapy, timing may be crucial
...is Cancer Center team set out to determine whether sequential administration would make a difference. The researchers tested erlotinib alone, the standard chemotherapy agent docetaxel alone, the two drugs simultaneously, and the two drugs sequentially. All the tests were done in the laboratory using human non-s...Other highlights in the May 19 JNCI
...this style of translational research. "Designing a sequential series of experiments, both laboratory and clinical, that lead intentionally to proof-of-concept adjuvant trials is all too rare. But, as Pegram et al. remind us, it is not impossible," he writes. Contact: Kim Irwin, Media Relations, Women's Cancer P...Drug combo effective in advanced breast cancer
...translational research at its best." "Designing a sequential series of experiments, both laboratory and clinical, that lead intentionally to proof-of-concept adjuvant (Phase III) trials is all too rare," Sledge states in the editorial. "But, as (UCLA researchers) remind us, it is not impossible." Jonsson Canc...Pre-term labor drug sensitizes brain to pesticide injury
...icular ailments, he added. "The adverse effects of sequential exposure to the two compounds on certain brain characteristics were more than the sum of the two agents' independent effects," Slotkin said. "Our findings suggest that exposure to drugs like terbutaline early in development can leave individuals set ...St. Jude shows how disorderliness in some proteins lets them interact with a diversity of molecules
...epers" of cell division. These timekeepers trigger sequential events leading to the production of new daughter cells. By binding to Cdk2-cyclin A and blocking its activity, p27 disrupts this sequence and prevents the cell from dividing. The importance of p27's role in regulating cell division is highlighted by...Translational repression in germline development
...y during Drosophila oogenesis involves a number of sequential processes. The Drosophila oocyte share cytoplasm with neighboring nurse cells via an incomplete cell membrane, allowing mRNAs and proteins from the nurse cells to be transported to the oocyte in the form of ribonucleoproteins. Following their export ...Automated analysis of bee behavior may yield better robots
...rchers are using the system to analyze data on the sequential movements that encode information — for example in bees, the location of distant food sources, Balch said. He will present the research at the Second International Workshop on the Mathematics and Algorithms of Social Insects on Dec. 16-17 at Ge...Collapse of seals, sea lions & sea otters in North Pacific triggered by overfishing of great whales
..."It's a plausible and unifying explanation for the sequential collapse. In a multiple causation world, this is likely one of the main causes." Traditionally, little attention has been paid to the role of predation in structuring open ocean ecosystems (i.e. top down effects). For the last 30 years most scientis...UC San Diego researchers receive $14 million from NSF for 10 new information technology projects
...on were known in advance. Now, he will investigate sequential compression algorithms that compress the sequence one symbol at a time, practical algorithms that can be performed using few operations per symbol, and extensions of these results to distributions with memory; such distributions model several practic...Dartmouth bioengineers develop humanized yeast
...eered the yeast P. pastoris to perform a series of sequential reactions (pathways) that mimic the processing of proteins in humans. After eliminating non-human pathways from the yeast, five genes were inserted causing the yeast to construct a new secretion pathway that synthesizes human-like glycoprotein struct......rt to addressing additional complications, such as sequential host species that interact on different trophic levels," explains Collinge. Collinge, together with Chris Ray, also of UC--Boulder, have organized a symposium, "Emerging Diseases: Stressing the Union of Community Ecology and Epidemiology," which will...Dartmouth engineers closer to mass-producing therapeutic proteins
...eered the yeast P. pastoris to perform a series of sequential reactions that mimic the early processing of proteins in humans. After eliminating non-human glycosylation from the yeast, several genes were inserted into the yeast in such a way that the yeast synthesized new human-like glycosylation structures. "...Scientists break down patterns in nature
...g another piece and splitting it, and so on. That sequential splitting generates a characteristic pattern in the sizes of rocks--and the abundance of species. It's also exactly the one we observe in nature. In short, Sugihara and colleagues have produced a fundamental theory of the patterns of nature free from...Oral contraceptives increase C-reactive protein, an infIammatory biomarker
...n half of women using first generation combined or sequential oral contraceptives of the 1960s. Among women using the then "low dosage" progestin oral contraceptives, the study found no difference in the prevalence of positive serum CRP between this class of OC users versus nonusers. Given the current availab...Study provides new insights into the functional neuroanatomy of motor imagery
...confirmed by comparing sensory-guided execution of sequential finger tapping with mental operations of equivalent sensorimotor representations. To exclude possible muscle contractions during motor imagery and to capture them during motor execution and responses, muscle activity was electronically monitored duri...