New treatment for fibromyalgia
...to abnormalities in the brain's neurotransmitters, serotonin and norepinephrine--chemicals key to mood and wide...types of antidepressant drugs, including selective serotonin uptake inhibitors and tricyclic agents, have had mixed results. A new and different antidepressant,...Serotonin metabolites in mollusks suggest pathways for human therapies
... to mammals, newly discovered chemical pathways of serotonin in the nervous system are paving a path toward fut...ression and other disorders. "Understanding novel serotonin pathways in a tissue-dependent manner is useful for the development of pharmaceuticals intended to p...Newly discovered protein may be key to muscular dystrophy
...or example, modulates a transporter that regulates serotonin concentration. Besides carrying messages from nerve cells to muscle cells, acetylcholine triggers communication between neurons in the brain, and is involved directly or indirectly in many diseases, including Alzheimer's and diseases of peripheral ne...Depression traced to overactive brain circuit
...ursor chemical from the blood and brain, depleting serotonin and often triggering symptoms in people with a his... that renders some people vulnerable to inadequate serotonin activity may be at the root of the mood disorder. The researchers scanned subjects after their bl...Scientists build on case connecting inflammatory disease and depression
...mical that regulates mood. Drugs called selective serotonin reuptake inhibitors (SSRIs) such as Prozac ease depression by elevating serotonin levels. "Although SSRIs can be used to treat immunotherapy-induced depression, they are not 100 per...Protective mechanism exploited by tumors may provide new cancer treatment
...n, and some popular antidepressants work by making serotonin more available to the brain. IDO suppresses the immune response by degrading tryptophan, which also is important to T cells, major orchestrators of the immune response. The MCG researchers were able to identify and isolate the IDO-expressing cells re...Brain serotonin enzyme finding might explain psychiatric disorders
...nzyme that specifically controls the production of serotonin in the brain. Different versions of that serotonin enzyme have a major effect on brain levels of the chemical messenger, which has been linked to many ...OHSU scientists find gene influencing drug withdrawal
...rawal gene." Mpdz's protein product interacts with serotonin receptors in nerve cells in the brain. Serotonin r...he human form of the Mpdz gene also interacts with serotonin receptors. "We know that there are different versions of the human Mpdz gene, but we don't yet know ...University of Chicago scientists pinpoint cellular cause of SIDS
... children who die of SIDS have decreased levels of serotonin in areas critical for respiration. Although he did...nk: In the pacemaker neurons critical for gasping, serotonin regulates the sodium channel. Now, Ramirez, along with six of his investigators, are looking more c...Donaghue Women's Health Investigator Program awards grants to three at Yale
...omen. van Dyck's research focuses on estrogen and serotonin receptors in menopausal women with depression. His study will examine the serotonin-2A receptor in the brain, especially in the prefrontal cortex. This receptor appears to be involved in the regulation of mood and the actions of antidepressants. R...VA/UCLA researchers pinpoint role of histamines in waking
...ls, cells containing histamine, norepinephrine and serotonin are active in waking and inactive in sleep. The r...aking. The team also found that norepinephrine and serotonin cell activity ceases in cataplexy, showing that their activity is related to muscle tone, rather tha...Ritalin may improve Parkinson's symptoms, OHSU study says
... of Parkinson's disease. Paroxetine is a selective serotonin reuptake inhibitor, or SSRI, a class of antidepres...d it because laboratory evidence has suggested the serotonin transporter, the system through which serotonin is reabsorbed into nerve cells, may take up dopamine...Purdue chemists 'put the twist' on protein building block
...r understanding of this close chemical relative to serotonin and melatonin could provide insights into these ot...peculated that tryptamine's chemical similarity to serotonin and other mood-related substances could lead to new basic knowledge about their function in the brai...Genetics, alcohol sensitivity, and behavior
...ndings regarding the role of a polymorphism of the serotonin transporter gene, SLC6A4, in subjective response t...response to alcohol. In fact, the L allele of the serotonin polymorphism was associated with a more rapid adaptation to alcohol effects (referred to as "acute t...Researchers-again-pinpoint why stress kills
...est as reduced heart rate variability, and altered serotonin activity affecting platelet function. Scientists have noted an important interaction between stress and ventricular arrhythmias, or loss of rhythm to the heart. This relationship has been supported by animal studies and in observation of some human p...UT Southwestern researchers study benefit of exercise, medication on depression
...th (NIMH) focuses on individuals taking selective serotonin re-uptake inhibitors, (SSRIs), who also participate in a 24-week exercise program. SSRIs are the most prescribed medications for depression and include such drugs as Prozac, Zoloft, Paxil and Celexa. "The majority of people who start on an SSRI feel...Tamoxifen's effectiveness may be compromised by hot flash drug
...ts, paroxetine and fluoxetine, which are selective serotonin reuptake inhibitors (SSRIs). SSRIs have been shown to inhibit the enzyme that breaks down tamoxifen into chemical agents called metabolites, including 4-hydroxy-tamoxifen, which was believed to be tamoxifen's most active metabolite. Twelve women ...Steroid use causes long-term agression, NU report indicates
...testosterone or steroids affect the development of serotonin nerve cells, which, in turn, decreases serotonin availability in the brain," Melloni says. "The serotonin neural system is still developing during ad...Gene mutation in rare familial form of Obsessive-Compulsive Disorder (OCD)
...new, uncommon coding region variant, I425V, in the serotonin transporter gene in 112 OCD patients found this va...new, uncommon coding region variant, I425V, in the serotonin transporter gene in 112 OCD patients and 271 patients with other psychiatric disorders plus controls...Diet may improve cognition, slow aging, and help protect against cosmic radiation
...s in the levels of the neurotransmitters dopamine, serotonin and norepinephrine, as well as some of their metabolites, in various regions of the brain. These levels were then compared to levels in control animals. At one week following the end of exposure, no significant changes were detected in the overall l...