Tag: "serpins" at biology news

Trapping metalloproteinases in a serpins coils

.Serpins are a family of proteinase inhibitors that bind to the catalytic sites of serine dependent proteinases. Tissue factor pathway inhibitor (TFPI-) 1, a well studied member of this family, is best known for its ability to limit the clotting cascade. Based on its structural similarity to TFPI-1, the related protein TFPI-2 was expected to play a similar role, and indeed, TFPI-2 can bind vari...
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