Structure solved at Scripps shows how one human protein reduces potency of chemotherapy
...of Medicine, who has been studying AGT protein for several years and is one of the authors on the study. However, says Daniels, this protection can cut both ways. "Tumor cell lines hijack [AGT's] function and overexpress the protein to escape therapies," he says. Cells in some tissues, such as the brain, n...RICE gets $1.1m from DOD to study neurofibromatosis
... fruit fly model for neurofibromatosis and to test several key proteins it has already identified as playing a key role in NF. For example, the fruit fly NF1 gene is very similar to its human counterpart, and Stern's previous work has shown that fruit flies lacking the NF1 gene or any of five additional gene...New compound 'highly efficacious' at reducing human tumour growth
... oral preparation. The compound was tested against several tumour models including both solid tumours and haematological tumours. The compound showed efficacy in all models. However, ZK-CDK was particularly efficacious in slow-growing, hormone-independent, p53-negative models e.g. advanced, anti-hormone refr...Study finds plant enzyme function changes with location in cell
...ly evolve to perform new functions by accumulating several shape-changing mutations, which can take thousands...ory have discovered another factor that can change several plant enzymes' functions instantaneously: their location within the cell. Depending on where these...Combination of gene therapy and gene silencing prevents neurodegenerative disease
...olyglutamine-repeat diseases, which include HD and several spinocerebellar ataxias. The study, conducted by scientists at the UI Roy J. and Lucille A. Carver College of Medicine and colleagues at the University of Minnesota and the National Institutes of Health (NIH), appears in the August issue of Nature Me...JCI table of contents, 1 July 2004
...platelets, which promote blood clotting. There are several forms of thrombocytopenia, each with different gen...insulin within the organism. The fat cells release several hormones and cytokines, which appear to play a role in controlling this response. One of these fat c...National Parkinson Foundation designates UNC as 'Center of Excellence'
...ovide state-of-the-art clinical care, he recruited several new faculty members, including Drs. Huang, Murrow, Alexander I. Trster and Daniel Kaufer, Huang leads UNC's translational research program in Parkinson's disease and Murrow is developing a nationally recognized deep brain stimulation program. Trster,...Cancer gene MYC emerging as key research target
...ue, McMahon's research team offers a reanalysis of several previous studies of MYC's binding to target genes. The unexpected discovery that MYC binds to a large percentage of genes without activating them calls into question long-held assumptions about MYC's functioning and opens new directions for MYC resea...How DNA repair machinery is a 'Two-Way Street'
...of the "mismatch repair" machinery is the cause of several types of cancer, including relatively common forms of colon cancer. The researchers, led by Howard Hughes Medical Institute investigator Paul Modrich, Ph.D., at Duke, reported their findings in the July 2, 2004, issue of the journal Molecular Cell. J......biological processes and is directly implicated in several human diseases. Rac is involved in tumor growth and metastasis in cancer; it is important for the proper functioning of immune cells and is necessary for the innate immune response; it is required for neuronal function and has been implicated in ne...Releasing pet fish into the wrong ocean proves a diaster
... orangespine unicorn fish, raccoon butterfly fish, several varieties of tang and angel fish, and the predatory lionfish. All come from the west Pacific, the north-west Indian Ocean and the Red Sea, yet they have been seen at 32 sites off Florida. "It's a Finding Nemo story," says Brice Semmens, a marine bi...Bacteria spill their guts to aid researchers in quest for new antibiotics
...ges shape in a living bacterium, but we also found several sites within the protein that, when modified genetically and chemically, can cause the channel to open inappropriately, thus killing the organism," Dr. Blount said. "If these regions of the protein could be modified pharmacologically, one may have th...Chemical Society announces EPA awards for environmentally friendly technology
... research team exploits the chemical properties of several solvents, including supercritical CO 2 , which is dense and compressible; nearcritical water with operating temperatures between 250-300 degrees Celsius; and CO 2 -expanded liquids, which can be easily separated. Each solvent offers unique advantages...Herpes tool allows researchers to customize Alzheimer's vaccine
...accine caused severe inflammation in the brains of several participants, and the study was halted last year b... system's array of forces. The team is conducting several more studies designed to contribute toward a custom vaccine against Alzheimer's. In addition, Bowers......d by Smithsonian Migratory Bird Center (SMBC); and several programs never implemented: Mexican Shade Coffee, Mexican Shade Coffee PLUS, and a draft from the Specialty Coffee Association of America. Traveling to Chiapas, Mexico the pair studied farming practices from traditional rustic management to a more i...Oxford Journals takes bold step towards free access to research
... of senior academic librarians, and talked through several potential models which we were considering for NAR... of senior academic librarians, and talked through several potential models which we were considering for NAR. Their feedback and desire to support the journal...Carnegie Mellon U. imaging study reveals sex-based differences that persist as mice enter adulthood
...tures than could be derived from human imaging for several reasons, according to Ahrens. The animals studied were nearly genetically identical and reared in the same environment -- factors that cannot be controlled in human studies. And the imaging technology, magnetic resonance microscopy, allows high resol...Kaposi's sarcoma virus 'reprograms' blood vessel cells into lymphatic cells
...hatic system and blood vessel cells and identified several genes, including Prox1, that usually were expressed only in lymphatic cells. They then infected blood-vessel-lining cells from human skin with the KS virus. A week later, they found that the viral infection had caused a significant increase in the ...APS awards more than $200,000 to middle and high school science teachers
...earch community, Frontiers in Physiology is one of several grant-supported programs that APS administers. For more information about APS Education Programs, email: education@the-aps.org or visit the APS website at http://www.the-aps.org/education.htm ....Scientist honored for studies of genetic influence on chemotherapy, tumor development
...h expenses, beginning July 1, 2004. Of the several awards given by the AACR the world's oldest and largest professional society representing cancer scientists from the United States and more than 60 other countries the AACR-NFCR professorship honors and fosters world class accomplishments among sci...