JCI table of contents: 1 September, 2004
...University of Texas MD Anderson Cancer Center, now show that a protein called Stat3 is required for skin c... The authors used inhibitory antibodies to further show that the protein p50, a part of the NF-kB complex, is necessary for protection from hyperoxic damage...Anti-cancer compound in vegetables found to block late-stage breast-cancer cell growth
...Journal of Nutrition. "This is the first report to show how the naturally occurring plant chemical sulfora...ote Jackson and Singletary. "However, the results show that tubulin disruption may be an important explanation for SUL's antiproliferative action." "These ...NASA satellites detect 'glow' of plankton in black waters
...d respiratory problems in humans. Previous studies show that prolonged "black water" patches cause water quality degradation and may cause coral death. The use of remote sensing satellites provides effective means for monitoring and predicting such events. The link between coastal runoff and black water ...Analysis of biological clock may lead to greater understanding of human disease
...onal models of the circadian rhythm of fruit flies show that the internal clock is robust, that is, not ea...ility, looking for the weak links, may be a way to show how disease is a failure of a robust system, according to the authors. "The huge progress of the las...How an insidious mutation fools DNA replication
..."We were able to extend the replication process to show that there were no distortions that would be detected by the polymerase. This means that the DNA would continue to replicate with this mispair, and that could potentially lead to stable incorporation of a lethal mutation," said Beese. In further anal...Advances in tumor angiogenesis Dendritic cells co-opted to the dark side
...re tolerated immunologically. "We are the first to show that dendritic cell precursors in tumors build blo... to demonstrate that this could happen in vivo and show its contribution to pathology and physiology." The work has also revealed that the bone marrow via...The future of HIV therapeutics is brightening, according to Gladstone Institutes Director
...its Vif protein. GIVI scientists were the first to show that Vif not only targets intracellular APOBEC3G for accelerated destruction, but also impairs new production of this antiviral factor. Vif's combined effects effectively overcome the antiviral action of APOBEC3G. The fact that Vif must bind to APOBE......ne to another HIV infection. Our findings clearly show that this is not the case and will have widespread implications for HIV management, diagnosis and prognosis." This groundbreaking news is in part due to the development of a new technical tool that permits cloning of the virus....Study in Science reveals recreational fishing takes big bite of ocean catch
...le the individual may take relatively few fish, we show that a few fish per person times millions of fishermen can have an enormous impact." "The large impacts of recreational fisheries surprised us, and they may startle many people, including fishermen, concerned about the health of our oceans. But if an...Streptococcus infects humans by thwarting blood clotting
... made significant amounts of human plasminogen. To show that the human plasminogen was functional in the mice, Sun crossed the transgenic mice with another strain in which their own plasminogen genes had been deleted. This cross essentially restored plasminogen function in the resulting mice. In test-tube...Researchers uncover secrets of immune system's munitions factory
...mphomas and some mature B cell tumors are known to show aberrant somatic hypermutation and class switching," said Alt. "Now that we know more about how the AID-RPA complex works, we can begin to address questions of how the aberrant processes might occur. "While this is currently pure speculation, it migh...What actually influences air pollution over the Indian Ocean?
...ental emissions, lightning and ships. The new data show pronounced, semi-regular plumes of nitrogen oxide ... versa for increases in NOx emissions. The results show that the influence of Indian emissions on the central Indian Ocean is limited to the winter monsoon ...Meteorites supplied Earth life with phosphorus
...bon, and nitrogen. Pasek cites recent studies that show there's approximately one phosphorus atom for every 2.8 million hydrogen atoms in the cosmos, every 49 million hydrogen atoms in the oceans, and every 203 hydrogen atoms in bacteria. Similarly, there's a single phosphorus atom for every 1,400 oxygen ...Regular physical activity really does boost immune system in older men
...ivity of about six hours a week. Previous studies show that the aging immune system suffers from a progressive decrease in function that can lead to several negative situations including increased risk of infectious disease and ineffective response to vaccination. It's been shown that regular moderate ca...Evidence for sympatric speciation by host shift in the sea
...ok University, Australia, used genetic analyses to show that a new species of coral-dwelling goby discover...mechanisms of speciation are possible, the authors show that sympatric speciation by host shift is the simplest explanation for the pattern of habitat use a...Circadian clock genes reign in duration of fruit fly copulation
... female flies copulating with normal males did not show a similar change in behavior. Both the period and timeless genes are evolutionarily conserved components of the molecular circadian clock mechanism and are present in diverse species including humans. Both genes play critical roles in the control of...Nevada researcher re-ignites mammal reproduction debate
...ished through diet. Such a study would be able to show whether mammal populations in different regions could be increased or decreased, based on the needs of those areas, she said. In eastern Nevada, for example, declining populations of mule deer could be better researched by taking into account Cameron...New compound could give some types of cancer the one-two punch
...odifying SU-5416," Li said. Laboratory experiments show that OSU 111 is one of the most promising analogs for killing cancer cells Li's team has found so far. When treated with OSU 111 in laboratory experiments, the majority of prostate cancer tissue cells died within three days, Li said. "This compound s......o be published online August 22 -- the researchers show that in humans, loss of one copy of each of two adjacent genes, known as ZIC1 and ZIC4, causes Dandy-Walker. The researchers then used this finding to create a mouse model to allow them to study the developmental basis of the disorder. "Dandy-Walker...