Structure solved at Scripps shows how one human protein reduces potency of chemotherapy
...ays Tainer. The molecular details of the structure show how AGT could be modified to resist selective inhibitors. This could be used to protect critical tissues from the chemotherapy even when administered at high doses. For example, a cancer patient taking chemotherapy and AGT inhibitors could at the sam...Summer in the South: Kudzu and oriental bittersweet
...fragmentation in the United States. Recent studies show that, although there are still large uninterrupted areas of forest in the United States, almost 62 percent of U.S. forest land is within 150 meters (492 feet) of the forest edge. Another study found that half of U.S. land area is within 382 meters (1...Croatian skeletons reveal changing status of cancer in Europe across the centuries
...ymptomatic tumours, so aging populations naturally show a higher incidence of the disease. "The individuals in the Croatian Skeletal Collection would have been prone to diseases such as syphilis, tuberculosis and leprosy (and we found evidence for each of these conditions in individuals in the collection...Chemoradioimmunotherapy for advanced breast cancer: hope for the future?
...tuation of the tumour cells. Evidence was found to show 1) there was clear downregulation of HER-2 as a consequence of the action of antiHER-2 scFv antibody; 2) there was re-expression of the tumour suppressor gene BRCA1 as a consequence of the inhibition of the DNMT1 mRNA and; 3) the radioisotopes had in...Macrophages, not stem cells, correct liver disease by fusion
...rradiation, which has severe side effects. Here we show this harsh treatment is not necessary for macropha... of proof is now on the people doing that work, to show that what they're seeing is not fusion."...Protein controls acid in cells by direct detection of volume changes, study finds
...thwestern Medical Center at Dallas. Their findings show that the protein NHE1, which is found in the membr...lgemann said. "Our advancements allow us to better show and study how these systems are working." Other UT Southwestern researchers who contributed to the s...JCI table of contents, 1 July 2004
...cells from cancer patients themselves. The authors show that patients' bone marrow is enriched for subsets... have added to the ghrelin's role in the body, and show it also has activity in the immune system. They found that ghrelin receptors are expressed in cells ...Digital evolution reveals the many ways to get to diversity
..., they are able to thrive and gain a foothold. "We show why more than one species can exist in a place," Ofria said."We've found that in a place where resources are finite, there are limiting effects of productivity." The Alife program, called Avida, is basically an artificial petri dish in which organism......cells from cancer patients themselves. The authors show that patients' bone marrow is enriched for subsets of anti-tumorspecific T cells. These cells were isolated from bone marrow and stimulated in cell culture to become effective killer cells. Mice that had been previously implanted with tumors were in......released from RhoGDI. In their current study, they show in vitro and in vivo that Rac is released from RhoGDI by an enzyme called p21-activated kinase (Pak). Pak is a kinase enzyme. Its job in the cell is phosphorylationto attach phosphate groups to other molecules inside the cells in order to modify thei...UNC scientists discover molecular pathway leading to nerve growth and regeneration
...t promotes nerve growth. "It is the first study to show the link between NGF and the building blocks that form the axon," said Dr. William Snider, professor of neurology and cell and molecular physiology at UNC's School of Medicine and director of the UNC Neuroscience Center. Axons are long tendrils, or p...Chemical Society announces EPA awards for environmentally friendly technology
...five research projects for creative chemistry that show promise for improving the environment. The award winners include scientists at the Georgia Institute of Technology, Jeneil Biosurfactant Company, Bristol-Myers Squibb, Buckman Laboratories and Engelhard Corporation. Since 1996, the Presidential Green...... a rustic farm, and it was also the only system to show significantly higher diversity of fruit-eating butterflies and birds more similar to those found in forest reserves. The other programs resulted in various levels of certification for the farming practices. Mas and Dietsch suggest setting specific r...Brightness discrimination in the dog
...ive at a firmer conclusion. This research helps to show that dogs' perceptual world is very different from ours, and that we cannot expect the same thing from them that we expect from ourselves....RSV can increase the risk of asthma, UT Southwestern researchers find
...e Journal of Infectious Diseases , is the first to show a link between respiratory syncytial virus, or RSV, infection and asthma in mice. A related study, also in mice, suggests that a medication neutralizing the virus could decrease children's chances of developing asthma. RSV is the leading cause of vir...Germans must research the history of reproductive medicine during the Nazi era
...iene', the German version of eugenics, in order to show how far eugenic and racial thinking can go, so that we can have it in mind when we discuss ethical questions on reproduction and fertility. If we do not, we face uncertainty, lack of information and confusion when considering ethical questions in th...Mice with hyperactive Wnt10b gene eat all they want, but have half the body fat of normal mice
...y fat than normal mice on a low-fat diet. And they show no signs of diabetes or other metabolic disorders, which are common in animals with too little fat. But don't stock up on potato chips and ice cream just yet. The genetically altered mice are leaner than normal mice, but they also have some less-than...Carnegie Mellon U. imaging study reveals sex-based differences that persist as mice enter adulthood
...and memory. The results, in press with NeuroImage, show that sex hormones alter the development of certain brain structures during puberty and that these effects persist into adulthood. The findings provide a much truer representation of how circulating hormones affect brain structures than could be d...Underground carbon dioxide storage reduces emissions
...ological Society of America. "We have been able to show that you can safely capture carbon dioxide that would otherwise go back into the atmosphere, and put it back into the ground. It's very exciting work." Carbon dioxide is a naturally occurring greenhouse gas in the atmosphere whose concentrations hav......an neurologist Markus Schuelke, M.D., and the team show that the child's extra-large muscles are due to an inherited mutation that effectively silences the myostatin gene, proving that its protein normally keeps muscle development in check in people. People with muscle-wasting conditions such as muscular...