Dog Blindness Gene May Help Humans
...rsand owners of the five dog breeds that have been shown through interbreeding to inherit the same defect: Labradorretrievers, Portuguese water dogs, poodles, and English and American cocker spaniels. "To understand the magnitude of the problem," Acland says, "consider this: With an estimated affected rat...Jefferson Researchers Use Gene Therapy To Treat Rare, Inherited Brain Disease
...ormation for the enzyme into the brain. They have shown that the system works in the lab and in animals. They then showed in preliminary studies in New Zealand that the Canavan gene could effectively be delivered into the brains of two children with Canavan disease, based on evidence of nerve myelination ...Heart and Soul: The Blood Vessels And Brain Use Common Guide
...is third receptor is neuropilin-1, a brain protein shown last summerto be a receptor for protein ligands variously called collapsins or semaphorins.The collapsin/semaphorin family is the latest in a slew of proteins implicatedover the past 20 years in axonal guidance. They function by inducing thecollapse ...Gene-Reading Problem Linked To Lou Gehrig's Disease
...eachother. Hopkins researchers had previously shown that many ALS patients have littleor noEAAT2 in certain areas of the brain and spinal cord, creating an excess ofglutamate that kills thenerves that control muscles. This usually leads to paralysis and death in two to five years. Nearly30,000 p...Growth Factors Shown To Increase Vitamin C In The Immune System
...e in regulating this process. Previous researchhad shown that growth factors caused immune cells to take up more glucose-- a process that increases the metabolic fuel available for cellular function.One of those growth factors, called granulocyte-macrophage colony-stimulatingfactor, or GM-CSF was purified ...RNA-Dendritic Cell Combo Shows Promise As A Universal Cancer Vaccine
...olorectal cancers. Thefirst phase of the trial has shown that the vaccine is not only safe but canproduce immune responses in cancer patients. Additionally, Lyerly has received federal Food and Drug Administrationapproval to start another phase 1 trial, using RNA extracted from colon cancercells. ...Yale Announces New Biotech Firm
...ve been treatedwith the medication, which has been shown to significantly enhance andextend lives. Yale also expects to earn significant royalties this year from aLyme disease vaccine being developed by SmithKline Beecham, which isawaiting U.S. Food and Drug Administration approval. The vaccine wi......ver, in thethree patients examined so far, we have shown a decrease in HER-2/neuexpression. This observation encourages us to continue our work in E1A, and weare excited about its potential as a therapy for several different types ofcancer." According to the AACR, over 180,000 new cases of breast cancer w...New Test Opens Window On Corrosive Free-Radical Activity In Individuals
... set of experiments, levels of8-epi-PGF2alpha were shown to be elevated in cigarette smokers, and vitamins Cand E were shown effective in lowering those levels. In another study,8-epi-PGF2alpha was found to be elevated during...Researchers Discover Ways The Ulcer/Cancer Bug Can Trigger Disease
...condition. In a differentstudy, Gordon's group has shown that undifferentiated cells in the stomachlining proliferate abnormally when parietal cells are lost. Such unrestrainedcell division eventually may increase the risk of cancer, Gordon suggests. "Sothough attachment isn't necessary for H. pylori infec...Dietary Determinants Of Iron Stores In A Free-Living Elderly Population: The Framingham Heart Study
...se. Iron-absorption studies from single meals have shown that many dietary factors can influence nonheme-iron bioavailability. However, little is known about the association of these dietary factors with iron stores in free-living elderly populations. To address this question, we investigated the consumpti...EPA Should Redirect Some Research on Toxic Airborne Particles
...actuallyreceive. "Recent studies have consistently shown that airborne particles are somehowassociated with adverse health effects, especially for people with heart andlung ailments," said committee chair Jonathan Samet, professor and chair,department of epidemiology, Johns Hopkins University School of Hyg...Microchip Sensor Detects Bacteria
... in the food processing industry. "As history has shown us, if a small colony of bacteria gets into the system, the cost, both in health and economic terms, can be enormous," he says. He notes that hospital-borne infections, battlefield threats, even community-acquired infectious disease are also applica...Adults Need To Increase Intake Of Folate; Some Women Should Take More
...ttee based its recommended intake levels on values shown to guard againstanemia or other conditions that ca...elop when these vitamins are lacking. Research has shown that consumption of folate and vitamin B6 can reduce elevatedlevels of homocysteine in the blood, an...Extra Choline During Pregnancy Enhances Memory In Offspring
...the first time that a common food nutrienthas been shown to cause permanent brain changes in regions responsible forlearning and memory. The findings could have important implications --especially for pregnant women and their children -- if choline proves to havethe same memory-enhancing effect in humans,...Eviction From Scum Home Makes Disease-Causing Microbe Vulnerable
...otics." In previous work, Iglewski's team has shown that Pseudomonascontrols several genes, including the lasI gene, through amechanism known as quorum sensing, where bacteria release achemical signal known as an autoinducer into shared surroundingsand monitor its level. When the signal hits a certain...Retinoic Acid Used In Cancer Treatment
... active form of vitamin A. The compound had been shown by other researchers to regulate normal cell growth and differentiation. Yen's latest results -- using transforming proteins to switch on proto-oncogenes, the precursors to oncogenes -- demonstrate how retinoic acid can use the same chemical-signall...Smokings Effects On Pregnancy Not Mitigated By Prenatal Vitamins, UB Study Finds
...d supplements during pregnancy. Studies also have shown that women who smoke during pregnancy are more likely to take vitamins -- and to take more vitamins -- than women who don't, possibly in an effort to offset the reported adverse effects of smoking. To determine if multivitamins are effective in...Obscure Enzyme May Play Major Role In Heart Disease
...sterol oxidation) affects atherosclerosis. He has shown that patientswith a high risk of coronary heart disease have increased LDL oxidation. He hasalso shown that mice and humans given dietary antioxidants, such as red wine orlicorice polyphenols, have reduc......airy products, and Brazil and some other nuts, was shown to be more protective for smokers than nonsmokers. The antioxidants vitamin C and E were found to be equally protective for both groups. The beneficial effects of each antioxidant remained significant even when all the antioxidants were considered ...