Tag: "sickle" at biology news

Commercialization deal boosts hope for new sickle-cell drug

...also reduces sickling of red blood cells. In sickle cell disease, the body produces an abnormal form of hemoglobin, the compound in red blood cells that carries oxygen. The hemoglobin clumps up and polymerizes forms long rod shapes. This polymerization bends the red cells into sickle-shaped structur...

Only 21 states offer newborn screening tests recommended by March of Dimes

...syrup urine disease; galactosemia; homocystinuria; sickle cell anemia; and medium-chain acyl-CoA dehydrogenase (MCAD) deficiency. The March of Dimes and the American Academy of Pediatrics also advise a test for hearing deficiency for all newborns. Newborn screening is done by testing a few drops of blood, u...

Surprises found in gene variation associated with schizophrenia

...phism also can be seen in a polymorphism linked to sickle cell anemia. In that condition, one copy of the po...of the variant gene cause the debilitating disease sickle cell anemia. ...

Sickle cell sufferers living longer, dying less from their disease

DALLAS March 25, 2004 Children with sickle cell disease an inherited red blood-cell disorder... children receiving the most modern treatments for sickle cell disease. It's also one of the largest published sickle cell studies to date. Researchers follow...

JCI table of contents, January 2, 2004

...ssociated with scavenging of nitric oxide, such as sickle cell anemia. Gladwin suggests "At the very least, perhaps we should avoid mouthwash and feel less guilty about eating hot dogs at the ball park." TITLE: Nitrite in saliva increases gastric mucosal blood flow and mucus thickness AUTHOR CONTACT: Jon Lu...

Researchers engineer mouse embryonic stem cells to form sperm cell precursors

...ective gene therapy for difficult diseases such as sickle cell anemia and muscular dystrophy, the use of embryonic stem cells is one of the most promising approaches, and to that end, fundamental knowledge of stem cells is a prerequisite," says Rastegar. In addition to NSF, this research was also supported ...

Premier international meeting provides latest news and issues in blood disorders

...of blood-related conditions, including hemophilia, sickle cell anemia, HIV-AIDS, leukemias and lymphomas, and blood clotting disorders. The Plenary Policy Forum (scheduled for Sunday, December 7, from 12:15 p.m. to 1:15 p.m. PST), will address health insurance coverage issues in the United States, and ...

Smallpox in Europe selected for genetic mutation that confers resistance to HIV infection

... to other diseases, such as the documented case of sickle cell anemia resulting from selection for resistance to malaria. "There are probably other alleles that have been selected by disease, but we just haven't found them," she said. "Diseases have the potential to exert strong selection. There is an arms ...

Researchers create 'supersized' molecule of DNA

...rth defect or a chronic disease, such as cancer or sickle cell anemia. ''The bases are where the real action occurs,'' Kool noted. ''What we've done in our experiment is to actually change them.'' xDNA In their study, Kool and his co-workers followed up on earlier experiments by chemist Nelson Leonard, no...

Old drug works new tricks for iron overload heart disease

...ron overload due to illnesses such thalassemia and sickle cell anemia are genetic disorders associated with elevated iron levels that particularly affect people of North American, European, Mediterranean or Asian descent," says Dr. Peter Backx, professor of physiology and medicine at U of T in the Heart & S...

DNA profiling is subject of two-day expert forum at Wright State

...ent of Professional Consulting Services, has run a sickle cell anemia blood testing lab and consulted in hundreds of cases including the World Trade Center bombing trial. Sandy Zabel, Ph.D., professor of mathematics and statistics, Northwestern University, participated in the first blue ribbon panel calle...

Researchers find mechanism that may determine early blood cell fate

...an deplete blood cells, or blood disorders such as sickle cell disease, beta thalassemia or alpha thalassemia. One common treatment has been to introduce HSCs into the body, where they produce new blood cells to counteract abnormal blood cells or replace absent blood cells. In the recent past, most blood ...

Journal announces scientific releases

...d disorders, ranging from leukemia and lymphoma to sickle cell to stem cell research. These will be made available free to the media at EurekAlert! Blood, the Journal of the American Society of Hematology, is the most cited peer-reviewed publication in the field. All articles undergo rigorous peer revie...

Insulin study sheds light on physics of crystal growth

...gen-carrying protein in the blood - that underlies sickle cell anemia. Vekilov's hemoglobin crystals were recently featured on the cover of the journal Science. Step bunching can lead to defects in crystals that can cause adverse consequences if those crystals then make their way into lasers. As the step b...

St. Jude researchers reverse blood disease using genetically modified stem cells

...d blood cell diseases such as beta-thalassemia and sickle cell disease. The St. Jude team overcame the obst...cing faulty red blood cells in beta-thalassemia or sickle cell disease. The large numbers of defective HSCs thwart attempts by gene therapy to reverse the dis...

Hydroxyurea therapy improves survival in most severely affected sickle cell patients

...al Institutes of Health. The study of 299 adult sickle cell patients with moderate to severe forms of the...educing the symptoms of the most severely affected sickle cell patients those who have 3 or more painful crises each year. "The current study shows that hy...

Physics tip sheet #34 - April 1, 2003

...etters (Print issue: March 28, 2003) Patients with sickle cell disease have mutant hemoglobin proteins that form long, stiff fibers inside red blood cells. Now, researchers propose a mathematical model to explain the persistent stability of these deadly fibers. The theory suggests that an inherent "twistine...

JCI Table of Contents, March 14, 2003

...er development. Encouraged by the observation that sickle cell patientshave increased numbers of cells expressing stem cell markers in theperipheral blood, Catherine Verfaillie and colleagues tested peripheralblood from patients during acute crisis and chronic stages of disease forthe presence of primitive ...

Stanford research points to chance as cause of genetic diseases in Ashkenazi Jews

... that lysosomal storage diseases may be similar to sickle cell anemia, in which people who carry two mutated copies of the gene have a disease, but those who inherit one copy of the mutation are protected against malaria. Those people - called carriers - are more likely to be healthy, have more children and...

New center will probe links between diet, genes and disease

...y director of the new center, "Just as our work on sickle cell disease in African Americans has broadened our understanding of blood disorders, I believe that focusing our efforts on minority populations with significant health disparities will give us the answers to better health for all Americans." "This...

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