Cardiac arrest may hinder ability to learn certain tasks
...ines projections from neurons involved in sending signal throughout the central nervous system and the body. There was an overall 18 percent decrease in dendritic spine density in the hippocampus in the cardiac arrest mice compared to the control mice, a finding that represents a functionally s...Knock knock knocking on rhythm's neural doors
... wrist while undergoing fMRI monitoring. A visual signal instructed the subjects to do one of three actions: rhythm -- flexing the wrist repeatedly at a comfortable pace, back and forth; discrete -- flexing the wrist, pausing, flexing it back, and rest. Another set of experiments had the timing of the rhy...A long-necked sea predator from China described in Science
...llowing its own pressure wake that would otherwise signal its approach, the predator may have executed almost undetectable strikes at unsuspecting fish. While it's difficult to add muscles to a fossil when there is little or no evidence for muscles in the fossil record, and even tougher when the fossil has...Experimental drug shown to block mutant protein causing blood disease
... to treat cancers by shutting down abnormal kinase signal switches. Gleevec blocks uncontrolled growth signals in Chronic Myelogenous Leukemia and Gastrointestinal Stromal Tumor. The Dana-Farber scientists have been testing PKC412 in patients with Acute Myeloid Leukemia, some cases of which are caused by a ...JCI table of contents September 15, 2004
...s) to activate macrophages and DCs through various signal transduction pathways. In response to LPS, a TLR turns on the serine/threonine kinase Cot/Tpl2, which then activates ERK1/2 in macrophages. It remains unknown whether Cot/Tpl2 is involved in responses to other bacterial components or in the activa-ti...Images of 'tail' of protein needed for cell multiplication suggest anticancer drug targets
...in pathway that puts molecular tags on proteins to signal that they should be destroyed. The ubiquitin pathway has dozens of different types of E2 enzymes, hundreds of different types of E3 enzymes and thousands of different targets. The NEDD8 workshop, however, has only one E2 and a few E3 enzymes, and NED...Joslin President awarded medal from international diabetes organization
...r. Kahn has literally defined the field of insulin signal transduction and mechanisms of altered signaling in disease. In 1981, Dr. Kahn's laboratory discovered that the insulin receptor is an insulin-stimulated enzyme with protein tyrosine kinase activity. His laboratory also demonstrated how insulin sig...Two Virginia Tech energy-related inventions win R&D 100 awards
...cted back. The message is extracted from the light signal using a PC plug-in spectrometer card, which makes the retrieval system low cost and portable. Since the optical fibers are the same as those used in the telecommunications industry, the cost of the fiber is also very low. Wang's group developed the ...Serotonin metabolites in mollusks suggest pathways for human therapies
.... "When serotonin is released, you do not want its signal to last forever," said Jonathan Sweedler, professo...r of chemistry and Stuart's academic adviser. The signal caused by serotonin is turned off by enzymes that inactivate it by converting it into various metabo...Wrapping a memory with an experience, capacity for recollection detected in non-human species
...rats have a capacity for recollection?" In humans, signal detection techniques have been used to distinguish memory responses triggered by familiarity, the general sense that a person or thing has been previously perceived, from those triggered by recollection, the sudden rush of detailed memory. The BU te...A new protein is discovered to play a key role in cancer progression
...to grow unchecked because they do not respond to a signal to die and stop proliferating from Transforming Growth Factor-beta (TGF-b). The cause of this signaling disruption of the normal cell cycle has not been fully understood. For the first time, scientists at Memorial Sloan-Kettering Cancer Center have d...Extreme stretch-growth of axons
...vious studies the investigators do report that the signal is from a mechanical stimulus along the length of the axon as opposed to a chemical stimulus. "The stretch is coming from the whole body growing," explains Smith. "For example, the growing spine bones in the whale likely exert mechanical forces on th...Identifying tick genes could halt disease, bioterrorism threat
... lie in wait until they receive the carbon dioxide signal that a meal is nearby. Then they leap, sink their mouths into flesh, and gorge themselves while at the same time spreading insidious diseases. Ticks feed on a diverse group of hosts including people, pets, livestock, reptiles and birds. Most of these...Highlights of American Chemical Society national meeting in Philadelphia, Aug. 22-26
...tra-low temperatures.") Current energy crisis may signal bigger problems around the corner, scientist warns -- Geologist Kenneth S. Deffeyes, Ph.D., Professor Emeritus at Princeton University, predicts that world oil production will peak on Thanksgiving Day, 2005, and production rates will subsequently fa...Tiny collars fitted on youngest-ever tiger cubs
...t home. The researchers waited until Galia's radio signal indicated that she had left the den site before se...hemselves die. The transmitters emit a "mortality" signal if the unit remains stationary for more than one hour. Finding the animal quickly is crucial in asce...Integrative biology of exercise APS Intersociety meeting October 6-9, 2004 in Austin
...Chair Eric Hoffman and Robert Grange. Mechanical signal transduction: response and remodeling in the muscu.... Chair Michael J. Joyner. Mechanical forces and signal transduction in vascular remodeling. Chair Steven S. Segal. Cytokines, muscle and metabolism. Chai...Trojan Horses, xenon imaging and remote controlled genes
...r example, the xenon molecule will emit a telltale signal that can be tracked by MRI. "Based on this principle, our lab is generating new biosensors that we hope will identify biomarkers associated with cancers of the lungs, brain and pancreas," Dmochowski said. "Over time, we'll be able to use MRI to de...Enzyme activation appears key in helping internal clock tell night from day
...ion, PKG-II may influence core clock components to signal the completion of nighttime processes and permit transit to the daytime domain. Thus, clock-controlled activation of PKG-II may serve as a critical checkpoint of temporal state at the night-to-day transition, which would align with dawn in the solar ...New model can aid in understanding immune system diseases
... antibodies against infection, then terminates the signal when the need for the immune response is gone. LMP...ein CD40, but not the viral mimic LMP1, is able to signal to organize the cells and tissues. "There are chemical messengers that cells normally use to tell ea......rt of a different 'cocktail' that communicates one signal at one time of the year to males, versus a different kind of message to females at another time of the year." Such insights have only whetted Drea's and Scordato's scientific appetites, spurring them to continue their studies. And, they emphasize, th...