Trial shows which brain cancer patients benefit from temozolomide
...ated MGMT promoter, meaning that the MGMT gene was silent and their DNA repair system was impaired. In this tested group 106 of the patients have been treated with radiotherapy and temozolomide. There was a 46% survival rate at two years for the 46 patients in the group who had a methylated MGMT promoter (s...Hardy buoys: Texas A&M project predicts oil spill movements
...se in areas where it wasn't needed." The buoys are silent sentinels standing watch over the Flower Garden Banks National Marine Sanctuary, the region's only coral reef, located about 90 miles south of Galveston. They warn of impending pollution, such as oil spills from the many oil drilling platforms in the...Molecule awakens and maintains neural connections
...outing of new connections and stimulates otherwise silent connections among immature neurons, and potentiall...evealed that Dasm1 was responsible for "awakening" silent synapses and promoting the maturation of the neuronal connections, a process that depends on dendrit...Malignant cancer cells generate mice through cloning
...s, such as methylation, can determine if a gene is silent or active. Konrad Hochedlinger and Robert Blelloch, postdoctoral researchers in the Jaenisch lab, studied whether any of these epigenetic influences can be reversed. First, they removed the nucleus from a melanoma cell and injected it into a de-nuc...Confidentiality of genetic databases questioned by Stanford researchers
...efore it can be shared. But the law is essentially silent on the issue of DNA, and most researchers have interpreted this to mean that sharing sequence data linked to information from a patient's medical history is safe. "Traditionally people believe that if there is no identifier attached, then the sample ...Nature's ambush: pregnancy more likely from single unprotected intercourse than believed
... who want a baby these biological mechanisms are a silent partner, helping to optimize the timing of intercourse. For couples who do not want a baby, however, these data are a caution. Such couples need to know that nature is subtly working against them," said Prof. Wilcox. He advises women who do not wish ...Junk DNA yields new kind of gene
...from yeast but from mammals, that these apparently silent regions produce RNAs, which are associated with transcriptional activity (see Focus, March 5, 2004 http://focus.hms.harvard.edu/2004/March5_2004/biological_chemistry.html ). Yet no one has found associated protein products. "For us it is easy to loo...Devastating parasitic weed may be felled by toxin borrowed from flies
...iated transformation. The introduced gene was thus silent in the healthy tobacco plant but turned on when it sensed an invading parasite. But would Egyptian broomrape be repelled by this souped-up off shoot of an antibacterial peptide from a flesh fly? Yes. But the results are somewhat uneven. In some in......chitecture of chromosomes from a transcriptionally silent state to an actively transcribed state. These findings have revealed fundamental information about how genes are switched on and off in the context of living cells. The method is likely to be used by many researchers interested in studying how a vari...... chromosomal rearrangements, and the rate at which silent mutations (DNA changes with no functional effect) accumulate in the genome. This would be expected, the researchers point out, because generations per year are a better measure of evolutionary rate than years themselves. (Generations in worms are abo...Study offers new insight into Rett Syndrome
...nactive, and MeCP2 would ensure that BDNF remained silent throughout the cell's life. Instead, they discovered a far more dynamic process. After the BDNF gene is methylated, MeCP2 does indeed bind to it, shutting the gene off -- but only temporarily. If the neuron cells are excited by any kind of environme...Hand-to-ear link in brain established after minutes of piano learning
...s of professional musicians have demonstrated that silent tapping of musical phrases can stimulate auditory areas of the cortex and hearing music can stimulate areas of the motor cortex. Moreover, according to anecdotal evidence, hearing music can cause pianists to move their fingers involuntarily. To find ...... vascular tone and blood pressure. Hypertension is silent killer and affects more than 40 million Americans, approximately a third of whom are not aware of the condition, resulting in an increased risk of heart attack, stroke, and kidney disease. Unfortunately, the root causes of progressive hypertension re...New mechanism for gene silencing identified
...nes are found in every cell of the body but remain silent in healthy adults. Scientists have learned, howeve...m involving multiple enzymes that keep these genes silent in healthy adults but active during critical times of embryonic development. Moreover, it appears th...Silent DNA architecture helps block cancer cell growth
...fic regions of chromosomal DNA into an inactive or silent architecture called heterochromatin. To distinguish these newly identified regions of specialized DNA architecture from previously known forms of heterochromatin, the researchers dubbed such regions senescence-associated heterochromatic foci, or SAHF...Process triggered by some anti-cancer drugs causes tumors in mice, study finds
... problems that affect whether a gene is active or silent not the genes sequence. One process receiving heavy scrutiny is among the most basic events in a cells nucleus during the life of the cell, methylation, during which methyl molecules, which can turn genes on or off, attach to the bases of an organis...Science highlights of AAN Annual Meeting in Honolulu March 29 April 5
...me structures active in the amateurs were entirely silent in the professionals. Not only do these results shed light on the neurological effects of training, they also indicate that post-stroke movement rehabilitation should be tailored to an individuals previous level of training and expertise in a particu...New research establishes genetic associations in hepatitis C
..., has been described as an insidious disease and a silent epidemic, mainly because the infection is often sub-clinical. Acute infection is recognized in a minority of patients and in most cases the virus results in chronic infections taking 10-20 years before the emergence of liver disease. In the US, almos...The structure behind the switch
...ng doesn't actually produce anything-it's called a silent transcript. And for another, the RNA strand remains firmly attached to each and every DNA nucleotide it touches-creating a sort of permanent RNA sandwich, with the RNA between two strands of DNA, though only attached to one of them. That's the R-loop...In a noisy world, how can the senses project and receive information at the same time?
... allowed free rotation of the animal. To allow for silent stridulation, the left wing of the crickets was re...nt opening wing movement. As a consequence, during silent stridulation, the ON1 response to acoustic stimuli was maximally inhibited during wing opening. Inhi...