Cancer vaccine based on pathogenic listeria bacteria shows promise targeting metastases
...3 complex. The result is rapid polymerization of a skeletal protein called actin that piles up and physically propels the newly formed bacteria around the cell. Portnoy thought that if he could eliminate the gene for ActA, he could prevent the bacteria from forming actin motors and spreading from cell to cel...16 APS exercise research highlights, from reduced flu mortality to proteomics & obesity
...bond mass, with the effects most pronounced during skeletal growth and development; rest periods reduce the ef...University, University Park) Influence of aging on skeletal muscle blood flow in healthy humans. Active leg sympathetic vasoconstrictor responsiveness appears t...Preclinical safety study shows adipose-derived stem cells improve heart function after heart attack
...of regenerative-capable cells such as bone marrow, skeletal muscle, embryonic and fetal tissue and rarer sources of stem cells. Additionally, regenerative cells from a patient's own adipose tissue (autologous-use) present no risk of rejection or disease transmission and avoid ethical concerns. The methods ...Experimental drug shown to block mutant protein causing blood disease
...e mutant FGFR1 is the culprit. These include human skeletal disorders such as Pfeiffer syndrome, which causes misshapen skull, face, fingers and toes, breast and pancreatic cancers, and brain tumors....JCI table of contents September 15, 2004
...rate from host myocardium cells, a small subset of skeletal myoblasts at the myocardial/skeletal muscle interface can become functionally coupled with host cardiomyoblasts, likely through fusion events between donor and host cells. TITLE: Spontaneous and evoked intracellular calcium transients in donor-derive...Men from early middle ages were nearly as tall as modern people
...e journal Social Science History. Steckel analyzed skeletal data from 30 previous studies. The bones had been ...h of the femur, or thighbone, was used to estimate skeletal height. The longest bone in the body, the femur comprises about a quarter of a person's height. Acco...Integrative biology of exercise APS Intersociety meeting October 6-9, 2004 in Austin
...e meeting Exercise-induced injury and repair of skeletal muscle: cellular and molecular mechanisms. Chair ...tabolic and transcription processes in contracting skeletal muscle. Chair Neil Ruderman. Comparative biomechanics and muscle function in terrestrial vertebrat...Marathoning mice could have Olympian effects on obesity
...dowed with the activated form of PPAR-delta in its skeletal muscles. The result was a dramatic increase in "non-fatiguing" or "slow twitch" muscle cells and a mouse capable of running up to twice the distance of a normal littermate without training. By expressing genes for an activated form of the receptor P...UCSD biologists develop 'super-endurance' strain of mice
...t UCSD, who headed the study. "By changing the way skeletal muscles respond to low-oxygen levels, we've develo...month-old mice that lacked the HIF-1 gene in their skeletal muscle, the scientists subjected groups of super mice and normal mice, with the HIF-1 gene, to a swi...Engineering endurance: The future of the Olympics?
...o Olympic marathoners. Running, like any sustained skeletal muscle activity, consumes large quantities of aden... and colleagues have discovered a protein found in skeletal muscle that profoundly influences muscle endurance, while Ronald Evans and colleagues genetically en...Genetically-engineered 'marathon mouse' keeps on running
...delta activity, they saw a major transformation in skeletal muscle fibers. The mice showed a major enhancement of so-called "slow-twitch" muscle fibers and a decrease in "fast-twitch" muscle fibers. Slow-twitch fibers are by far the more fatigue resistant of the muscle fibers. This is due to their large numb...Muscles are smarter than you think
...cles use a 'clever trick'. Muscle contraction in a skeletal muscle fibre in response to a nerve impulse is the result of a complex series of events known as excitation-contraction-coupling. There is a network of tiny tubes in muscle fibre known as the T-system that allow electrical signals, set up on the musc......d the gene expression in the liver, kidney, aorta, skeletal muscle, and the suprachiasmatic nucleus of the hypothalamus, and they looked for cyclic expression. What the data showed was that about 10 percent of the genes cycled, but most showed little overlap from tissue to tissue. This type of cycling has ...Emory researchers map structure of anti-cancer molecule
...microtubules, the hollow cylinders that serve as a skeletal system for cells and a scaffold for chromosomes in the dividing cell. When epothilones or taxanes bind to tubulin, the protein loses its flexibility and the microtubules can no longer disassemble, halting cell division. To build the model, ...Joslin Diabetes Center launches research section on developmental and stem cell biology
...ecific adult stem cell populations in bone marrow, skeletal muscle, the heart and the pancreas that may function robustly to regenerate or repair damaged adult tissues. The identification of such cells may have important implications for treating many of the long-term complications of diabetes. In addition, ...JCI table of contents, 2 August, 2004
...*********** Wasting Away in Muscle-ville Loss of skeletal muscle tissue, termed cachexia, occurs in over hal...er cachexia is regulated by selective targeting of skeletal muscle gene products AUTHOR CONTACT: Denis C. Guttridge The Ohio State University College of Medici...'Smart gene therapy' protects against damage from heart attack
...ected the gene construct into the heart, liver and skeletal muscle of three rats in the laboratory. Five weeks later, they restricted blood flow to the animals' organs by clamping key arteries for a period of an hour and then examining the organs for evidence of injury. Inducing ischemia and oxygen deprivatio...Loss of skeletal muscle tissue, termed cachexia, occurs in over half of cancer patients and, rather than tumor burden, is the direct cause of nearly one-third of cancer deaths. There are several regulatory proteins that are released from immune cells are known to be ...Misfiring proteins tied to inflammation and sick feeling of type 2 diabetics
... signaling and insulin-dependent glucose uptake in skeletal muscle in mice and speeds recovery from lipopolysaccharide-induced sickness behavior. Freund theorizes that combining vanadyl sulfate with rapamycin, a drug used to lower the risk of rejection of transplanted kidneys, might reduce diabetes-associated...Gene therapy reaches muscles throughout the body and reverses muscular dystrophy in animal model
... deliver therapeutic levels of dystrophin to every skeletal and cardiac muscle of an adult, dystrophic mouse," Chamberlain said. "These muscles include the heart, the muscles used during breathing, and all the limb muscles. The mice show a whole body effect, with a dramatic improvement of their dystrophy." ...