PTC Therapeutics' researchers identify biochemical pathway important for modulating cell growth
...cies such as leukemia, lymphoma, multiple myeloma, solid tumors, and inflammatory diseases such as psoriasis. "The recent work by PTC's researchers is extraordinary in that it creates a physical, and possibly regulatory link between the pathways that create RNA messengers and those that create the transl...Stretching DNA on a tiny scale, researchers probe the basis for its compaction
... findings and techniques employed here establish a solid foundation for further work on such questions....Brain cells become more discriminating when they work together
...sociate John D. Allison provides some of the first solid evidence that the exact timing of the tiny electrical spikes produced by neurons plays an important role in brain functioning. Since the discovery of alpha waves in 1929, experts have known that neurons in different parts of the brain periodically co...New book urges ecologists to think 'outside the helmet'
...an traverse across scales of ecology and provide a solid foundation for future studies"....Fish no exception to trend in marine-organism disease
...: "This is the first quantitative study to provide solid evidence that rates of disease do seem to be increasing in the ocean. It has been hard to tell if disease is increasing because we didn't have proper baselines. It's been much tougher to understand the frequency of marine disease than it is to monito...DNA research highlights prostate cancer mechanisms
...line edition of Carcinogenesis, provides the first solid evidence that the normal repair process is altered in prostate cancer cells, possibly leading to a cascade of events that culminate in further DNA damage and cellular dysfunction. Free radicals---highly reactive molecules generated by both normal me...Received truth turned on end in cancer research
...the development of leukemias, on the one hand, and solid tumors like breast cancer, prostate cancer, gastro...o transform into cancer cells. On the other hand, solid tumors, which make up the majority of all cancer cases, have been seen as developing as a result of ...Ancient Greeks help scientists build environmentally friendly nano devices
...f an intricate 3D jigsaw which is then filled with solid metal or active plastic using the same technology used for plating jewellery. This new technique has been inspired by the lost-wax casting process used by the ancient Greeks for sculpture, but scaled down by a factor of one million. This new technolo...First flavors form a lasting impression
... to be established long before the introduction of solid food."...Best way to clean up toxic plumes? Give 'em a pill
...s it was before." So he and his colleagues created solid forms, or chunks, of organic material that contain potassium permanganate. When buried in wet soil, these chunks slowly dissolve over a matter of weeks and months. These chunks allow researchers to better control the distribution of potassium permang...NJIT chemists pave way for cheap, usable field test for polluted, toxic, water, air, food
... synthesis." This latter approach also involves a solid phase extraction in micro channels through which fluid flows on nanoparticles. Mitra's research interests include the development of analytical techniques and the applications of chemometrics to analytical and environmental problems. Current ...Survey reports fall in stem cell transplants for breast cancer
... transplants were carried out for various types of solid tumours in Europe between 1991 and 2002. Breast ca...ediatric Diseases. Seven other specific types of solid tumours germ cell cancer (12%), neuroblastoma (9%), Ewing's sarcoma (7%), soft tissue sarcoma (4%),......w that FAP is present in about 90 percent of human solid malignancies, so that makes this protein a target well worth pursuing," Cheng said. "Antibodies have an inherent advantage in that they can specifically target FAP and not other proteins. Although the antibody we have studied so far has had only mo...Building the whole cell from pieces
... experimental techniques. "This study has built a solid framework for further research with the great advantage that the whole is greater than the sum of its parts: new experiments will improve it continuously", Aloy says. "The number of machines that we can place into the network will increase exponentia...Awards honor Alt's three decades of genetic cancer research
...in mice, they get all sorts of cancers lymphomas, solid tumors, you name it," Alt says. Interestingly, simply reducing H2AX activity is enough to cause genomic instability. "You can't just think that a tumor suppressor gene has to be completely mutated or gone to contribute to cancer," he says. "We need...Tigers: Big cats need cat food
...er in Maryland have developed a model that shows a solid quantitative relationship between tiger numbers and the amount of prey available to these highly endangered big cats. Published in the latest edition of the Proceedings of the National Academy of Sciences, the model can not only accurately predict t...Cross-species comparison reveals shared features between tumorigenesis and organogenesis
... shared mechanisms of normal organ development and solid tumor formation. By studying the cerebellum (the structure in the brain largely responsible for coordinating motor activities) Drs. Alvin Kho, Isaac Kohane, David Rowitch, and colleagues at The Children's Hospital and Dana-Farber Cancer Institute in...Combination therapy drives cancer into remission
... common in leukemia, lymphoma, and in a variety of solid tumors. Therefore, the combination therapy outlined by the new study is a promising general strategy for treating many cancers that are refractory to current therapies. The drug chosen to restore the programmed cell death mechanism was the antibiotic...Gene variants may increase susceptibility to type 2 diabetes
...h funded the three studies. "The work builds on a solid foundation of advances in basic cell biology, studies in human populations, and new gene-scanning technologies." Other groups still need to confirm their results, Drs. Collins and Permutt stress. In fact, scientists are already looking for the varia......and human primitive neuroectodermal tumors provide solid grounds for considering mammalian Lgl1 a candidate mammalian tumor-suppressor gene."...