UT Southwestern receives $1.78 million grant for obesity research as part of NIH Roadmap initiative
...other diseases. These are problems that need to be solved with input from people who think creatively about metabolic problems, and that's what UT Southwestern brings to this effort." This initiative is led by the National Center for Research Resources. The NIH Roadmap is a series of far-reaching initiative...Schepens Eye Research Institute receives 'Roadmap' grant to develop center for curing eye diseases
...olutions to biomedical problems that have not been solved using traditional, disciplinary approaches," said NIH Director Elias A. Zerhouni, M.D. "By providing this sustained and systematic support to interdisciplinary research through these new Exploratory Centers, we hope scientists can make progress on ...First glimpse of DNA binding to viral enzyme
...egion of the adenovirus protease that has not been solved by other techniques and can be used in drug design." At the National Synchrotron Light Source -- a facility that produces extremely bright beams of x-ray, infrared, and ultraviolet light at Brookhaven Lab -- Einstein's Sayan Gupta, the study's......vious studies when our collaborator Dr. Yigong Shi solved the crystal structure of Smac interacting with the target protein IAP," said Wang. "We realized that the interactive motif of Smac with that protein is only four amino acids, so it was possible to make a small-molecule mimic." According to HHMI inve...Scientists visualise cellular handmaiden that restores shape to proteins
...n complex is one of the largest and most difficult solved by scientists. Each unit of the cage or cap is mad... synchrotron facility, all authors collaboratively solved the structure....Emory researchers map structure of anti-cancer molecule
...h researchers at three national laboratories, have solved the structural puzzle of how an emerging class of promising cancer drugs work to halt cell division. The discovery potentially opens the door to the creation of more effective cancer treatments. "Uncovering and mapping the structure of this...Bad news for pathogenic bacteria: Scientists find protein essential for bacterial survival
...tch and Ohio State microbiologist Vladimir Svetlov solved high-resolution crystal structures of DksA. Solving this structure meant that the researchers could at last determine just how DksA helped ppGpp hold fast to its target, RNA polymerase. DksA uses something scientists call the "backdoor of gene e...LICR/UCSD team solves mystery of centromeres
...lifornia, San Diego (UCSD) School of Medicine have solved one of genetics' mysteries how a segment of protein on each of the body's DNA-carrying chromosomes is able to form a rigid structure called a centromere, leading to proper cell division and the faithful inheritance of genes. Published in the J...New model explains why costly insect 'outbreaks' hard to predict
... Another mystery that Dwyer's team appears to have solved is the question of why insect populations of the same species, even when they are thousands of miles away from each other, surge simultaneously. This is the only outbreak model that portrays what scientists call spatial synchrony. Which pres...Findings suggest need for new view of p53 cancer protein's interaction with DNA
...species to species, Halazonetis and his colleagues solved the structure of the binding region of a protein called Cep-1 from C. elegans, a roundworm, and compared it to the binding region of human p53. Their assumption was that, because the Cep-1 protein and human p53 bind to nearly identical DNA sequences ...Structure solved at Scripps shows how one human protein reduces potency of chemotherapy
...cal Biology at The Scripps Research Institute have solved the structure of a human protein called AGT that i...journal Nature Structural & Molecular Biology, was solved in the laboratory of Scripps Research Professor John Tainer, Ph.D., by Research Associate Douglas Da...New computational tools to aid in protein research
...nlike previous techniques, Wang's equations can be solved exactly in a manner similar to solving the quadratic equation of high school algebra fame. Wang and Donald hope that their work proves helpful to both structural genomic researchers as well as to those in the broader structural biology field....Molecule that 'blocks' key bacterial enzyme may lead to new antibiotics
...clusions. "It was only last year that we solved the structure of this molecule, just 21 amino acids long, remarkable both in its size and its structure," said Ebright, a participant in the original structural studies, along with Severinov. "A great many papers have been published on this ...Scientists receive awards, give lectures at the ASBMB/IUBMB meeting
...uctural basis for the immune response. His group solved the structures of the molecules responsible for attenuating the T cell response. In an "atoms-to-animal" research strategy expected to serve as a paradigm for future structural biology studies, he is now involved in research that will ultimately be e...Molecular image of genotoxin reveals how bacteria damage human DNA
..., and you end up with a single drop." Stebbins has solved the structures of over ten other proteins, including the cancer-related VHL tumor-suppressor and several other bacterial toxins, before solving the structure of CDT....Why some diabetics are at greater risk for UTIs
...4 -- Researchers at Midwestern University may have solved the mystery as to why some diabetics are at greater risk for getting urinary tract infections (UTI). They report their findings at the 104th General Meeting of the American Society for Microbiology. "Patients with type-2 diabetes and females with g...22-amino acid bacterium created by Scripps scientists
...icularly useful now that the human genome has been solved and scientists are now turning their attention to what these genes are doing inside cells. Other unnatural amino acids contain photoaffinity labels and other "crosslinkers" that could be used for trapping proteinprotein interactions by forcing int...Fire ant killing protozoa found in 120 Texas counties
...lot of questions to be answered and problems to be solved first. The first question, Mitchell said, is where did the protozoans come from? Though there are several native species of fire ant, their stings pale compared to their more aggressive cousin, the red imported fire ant, which was accidentally intr...2004 Max Planck Research Prize for Martin Vingron and Eugene W. Myers
...ne segments in the right order (assembly) could be solved by first selecting the clones according to their length. Using simulations, he was able to resolve the sequence overlaps for the entire human genome using only clones of defined length. This proved to be the key to the assembly of the complete genome......articipants were given word problems--which can be solved quickly with or without insight, and evoke a disti...ects pressed a button to indicate whether they had solved the problem using insight, which they had been told leads to an Aha! experience characterized by sud...