JCI table of contents, 16 August, 2004
...ng is Everything TITLE: Temporal perturbations in sonic hedgehog signaling elicit the spectrum of holoprosencephaly phenotypes AUTHOR CONTACT: Jill A. Helms Stanford University, 257 Campus Dr., Stanford, CA 94305, USA Phone: (650) 736-0919; Fax: (650) 736-4374; E-mail: jhelms@stanford.edu View the P...Stanford researcher's findings may shed light on common, deadly birth defect
...ne to interfere with developmental signals sent by sonic hedgehog, a protein previously implicated in HPE. ...in children with HPE. Intriguingly, exposure after sonic hedgehog had already established itself in the divided brain affected only the embryo's face, and ho...NCAR aircraft, ground instruments to track carbon dioxide uptake
... 100 and 200 feet tall, carbon dioxide sensors and sonic anemometers will measure changes in carbon levels and winds high above the tree tops. "Today we usually look for carbon in all the wrong places," says Schimel, "focusing on where it's easy to measure rather than where fluxes are largest." Most curren...USC scientists uncover secrets of feather formation
...enetic protein 4 (BMP4), and the whimsically named sonic hedgehog (Shh)-were found to result in new feather...space between the barbs. But when we took away the sonic hedgehog signal, cell death no longer occurred. It is a similar process to that which occurs in the ...Tagging the great white shark...and a few of his friends
...ags, satellite-linked data recorders, archival and sonic tags) has proven enormously successful. Animal movements and behaviors can be linked to oceanographic processes by integrating biological and physical data providing both atmospheric and oceanographic information, and offering unprecedented insight...Sonic Hedgehog shapes the brain
...ents, the researchers showed that a spot source of sonic hedgehog turned the arcs into a pattern very much like the eyespot of a butterfly's wing. "What we have found in brain development is actually a very simple principle", said Ragsdale. "It was known that morphogens like Sonic Hedgehog can induc...Concorde to blame for missing pigeons?
... of infrasonic shock waves generated by Concorde's sonic boom during supersonic flight. To find out, he compared the birds' predicted routes home with Concorde's flight paths and departure times on the days the races took place. The calculations showed that in all the races, the hapless pigeons would have ...UCSF researcher reports on protein therapy to reverse facial birth defects
...rchers have learned that one central player is the sonic hedgehog protein, which is named after a video gam...o that these excessive doses of vitamin A suppress sonic hedgehog activity in the embryonic facial tissue. Since at least some dietary vitamin A is essenti......he virus secreting this molecule--a protein called sonic hedgehog (Shh)--was injected into cells at the limb amputation site during different stages of regeneration. In testing the function of Shh in these cells, researchers learned more about the role this protein plays in the regeneration process. D......oa. Gerstein is alreadyworking on a high-frequency sonic beacon that could be attached to boat motorsin order to warn manatees away....... been found to result from mutations of the human sonic hedgehog gene. However, other chromosomal regions, including as yet unidentified genes, also produce very similar birth defects. For this reason, scientists are eager to learn more about the precise role of the human equivalent of the zebrafish cyclo...... distortion to createexpressive, harmonically rich sonic environments. A demonstration performance, featuring musiciansexpert in the styles of Hendrix, Dolphy, and others, will be held on Monday afternoon, June 22,immediately following this session. Those Creatures Have Rhythm Scientists are attempting ...