Images of 'tail' of protein needed for cell multiplication suggest anticancer drug targets
... tail. This problem was overcome using a technique specially developed by Robert Cassell, a macromolecular specialist III in the St. Jude Hartwell Center for Biotechnology and Bioinformatics. By substituting a molecule called selenomethionine in place of certain amino acids in the E2 tail, he modified the E1-E...Decreasing toxins in brains of Alzheimer's patients keep cognitive deficits at bay
...ound that scores of the eight patients who had the specially designed shunt continuously operating for one year stayed stable. However, the scores of patients who did not get the shunt declined by 20 percent after 12 months. "What's interesting is that the patients without the shunt didn't stop taking their re...Gene alteration points to longevity, thinness
...chers found in the fruit fly by feeding C. elegans specially engineered bacteria that knock down the activity of Indy. Their model netted a 15-20 percent increase in lifespan in addition to the other benefits. Unlike true genetic knockouts, with scientists completely removing both copies of a gene so 100 perc...Finding the hole in the defenses of cavity-creating microbes
...ientists have known for some time that the microbe specially modifies itself once it starts producing acid in the mouth. The Quivey group has shown that the changes include shuffling fatty acids in its membrane much like a bricklayer might move bricks to fortify a fence so it can withstand the wash of acids......ried out by three icebreakers: the Vidar Viking, a specially equipped drillship, the Swedish Oden and the Russian nuclear-powered icebreaker, Sovetskiy Soyuz. The drillings will be carried out at a depth of about 1,000 metres by the Vidar Viking. The task of the other two icebreakers will be to protect the dri...Chemical reaction in birds provides sense of direction during migratory flights
...rientation chosen by these birds. The stimuli were specially designed to allow for responses that could differ depending on whether birds used small magnetic particles on their bodies or a magnetically sensitive photochemical reaction to detect the magnetic field. We found that the birds faced in the usual di...National Cancer Gene Therapy Foundation gives $4.0 million in research grants
...in about one-out-of-three breast cancers. Using a specially developed laboratory animal model, this group has demonstrated that the combination of neu-targeted vaccination and neu-specific monoclonal antibodies eradicates neu-expressing tumors in nearly half the animals, while the individual treatment compone...NASA-inspired technology may help preserve women's future fertility after cancer treatment
...sence of follicle-stimulating hormone (FSH) in the specially designed systems and in a conventional culture system to evaluate resulting changes in egg structure and maturation using the different mediums and culture systems. "Our goal is to understand which features of the artificial environment contribute si...Estimated one in five people worldwide lack enough zinc in diet
...gical supplements such as tablets or syrups, or as specially formulated zinc-fortified foods; National programs to fortify staple foods (e.g., flour), a strategy already employed to deliver other nutrients such as iron and folic acid; Public education on good dietary sources of zinc, such as animal source fo...Study offers new model for breast cancer
...ized" the remaining tissue by injecting a layer of specially engineered human stromal cells. This created a hospitable environment into which she could then incorporate human epithelial cells. The mice soon formed functional human mammary glands, and when these mice became pregnant, the engrafted cells produce...Prenatal exposure to second-handsmoke greater for disadvantaged children, study finds
...r of pregnancy, for approximately 45 minutes, by a specially trained bilingual interviewer. From those interviews, data were obtained on their exposure to second-hand smoke, also known as Environmental Tobacco Smoke (ETS), and on their socioeconomic status and living conditions. The ETS exposure was further...Teens and young adults the new frontier in cancer says US cancer specialist
... adult care programmes. "Until we devote resources specially to this age group, there will be little progress. In the US it is difficult to show that, over all cancer, 15 to 30 year olds are better off today than they were a quarter of a century ago." Professor Bleyer said he was delighted that the Teenage Can...HIV exhausts the immune system through chronic non-specific activation
... to multiply and differentiate--that is, to become specially equipped to recognize and target a particular pathogen, or antigen. When the researchers analyzed T-cells from a group of untreated HIV infected individuals at different stages--acute infection, chronic infection without progression, and chronic infe...Optically recording millisecond brain nerve impulses
... bright laser light of multiphoton microscopy with specially developed dyes and a phenomenon called second-harmonic generation, biophysicists at Cornell University and Universit de Rennes, France, have made high-resolution images of millisecond-by-millisecond signaling through nerve cells. The first demonstrat...Passwords to guard entry aren't enough to protect complex data
...y" shared data that only can be seen clearly using specially supplied equipment. As data increase in complexity, it becomes increasingly difficult to define a good security model that works well for different types of collaborating users. For example, customers of an online file-sharing business need to be abl...Human embryonic stem cells may promise medical advances
... "Our approach opens the door for the use of these specially developed cells in transplantation medicine." Embryonic stem cells have previously been produced with cells from mice using the same method, called "somatic cell nuclear transfer." But, achieving this trick with human cells posed unique challenges,...The Rosetta space probe's long trek to Comet 67P/Churyumov-Gerasimenko
...al its magnetic and electrical properties. Using a specially designed camera, the lander will take pictures in the macro and micro ranges and send all the data thus acquired back to Earth, via Rosetta. "This will be our first ever chance to be there, at first hand, so to speak, as a comet comes to life," Schwe...Primate testes grafted into mice rapidly produce fertile sperm
... rhesus monkeys was grafted under the back skin of specially prepared mice. Sperm taken from the grafts at various times were analyzed to see if they would lead to viable rhesus embryos. When injected with sperm taken from grafts after more than 8 months, 9 of 16 rhesus oocytes began to divide normally. This i...New device can help defend against novel biological agents
...ing developed the three additional sensors out of specially coated electrodes. They attached these to another commercial device that has recently come on the market, called a multipotentiostat, that allowed them to take simultaneous readings from the sensors. One of the biggest problems they had with these mo...Purdue research suggests 'nanotubes' could make better brain probes
...m the University of Nebraska. The nanotubes were specially designed so that their surfaces contained tiny bumps measured in nanometers, or billionths of a meter. Conventional silicon probes do not contain the nanometer-scale surface features, causing the body to regard them as foreign invaders and surround t...