NIDR Supports Total Genome Studies Of Major Oral Pathogens
...nism, and current NIDR-supported projects focus on specific factors ratherthan the total spectrum of pathologic mechanisms. Determining the completenucleotide sequence of Aa will eventually yield a more complete picture ofpathogenesis. Aa will join the ranks of eight other microorganisms whose genetic blu...New Form Of Gene Therapy Holds Promise For The Future
... production of luciferase,the researchers inserted specific short pieces of deoxyribonucleic acid (DNA) infron...," said Munford. "If thegene can be delivered to a specific site, such as an inflamed joint or an organabout to be transplanted into a recipient, it may be poss......phaninreglates the circadian system, but found the specific neuronal pathway throughwhich orphanin acts. "This could lead to some important clinical applications,"says Allen. "If we know the receptor site where orphanin works on the circadiansystem, we may be able to use that information to come up with new w...Colorado State Scientists Tackle Genetic Makeup Of Obscure Bacteria
... what causes drugresistance and virulence in these specific strains so we can manipulate thoseeffects and prevent disease."...Reanalysis Of International Data Finds Sharp Decline In Sperm Density
...sed." Although the authors do not address the specific causes of this phenomenon,some recent studies have focused on the relationship between environmentalexposures and declining sperm quality. In one such study, researchers reported asignificant correlation between lowered sperm densities and increased ...Eating Lake Ontario Fish Linked To Shorter Menstrual Cycles; Consumption May Delay Pregnancy
...are aware of the advisory, but many don't know the specific recommendations for women and didn't change habits because of the advisory. For the two studies of fecundity and Lake Ontario fish consumption, researchers from UB's Department of Social and Preventive Medicine assessed both time-to-pregnancy, a...Scientists Identify A Novel Mitotic Regulatory Mechanism
...ecognition of the binding partners is sequence- specific and extraordinary dependent on phosphorylation of the target sequences. This consensus binding specificity has been shown to correctly predict some novel isomerase targets. Surprisingly, the target sequences are overlapping with antigens ...Human Breast Milk Contains Obesity Hormone
...that leptin circulates in the bloodstream bound to specific proteins, and this binding process is saturated -- or at its upper limit -- in obese people. The next step for the researchers is to see whether breast milk has leptin-binding proteins that may influence the amount of active leptin available for the ...Pitt Researchers Construct Novel Delivery System For Gene Therapy Of Liver Disorders
...r," remarked Dr.Huang. "By selecting genes specific to a patient's disorder, eventually we maybe able to use this delivery system to jump start the body's production oftherapeutic proteins and enzymes, which will offer patients with hepatoma, viralhepatitis, cancer and other disorders a viable treatme...Cellular Engineers Design Custom Cell Surfaces Able To Adhere To Synthetic Materials
... to the cells. Cell surfaces modified for specific reactions hold great promise in theconstruction of...tobiosensors, in which cells designed to lock onto specific compounds can becombined with an electronic, transducing substrate to signal changes in theenvironme...... suicide response occurs in plants exposed to this specific form ofbacteria, we can work on finding ways to develop potato plants that give thissuicide response even when they are invaded by bacteria for which they arehosts." Ishimaru said the suicide response is the result of a sophisticatedinterplay...Chlamydia Vaccine Developed At UMass
..." by the recipient, prompting the body to generate specific antibodies, which result in immunity to disease. B...ccine and Processes" and a second one covering the specific oral vaccine, using the special antibodies. A third patent, for diagnosis of chlamydial infections i......nerve cells. Single olfactory neurons also showed specific responses tooctanal, confirming that rat I7 protein responds to the chemical. The discovery will help answer many questions about smell, the leastunderstood of the human senses. Do receptors that are coded by similar genesdetect odors of th...... genotyping has confirmed an earlier findingthat a specific gene predisposes its carriers to psychiatric illness. In the January 1998 issue of Molecular Psychiatry, Ronnie G. Swift, M.D.,associate professor of clinical psychiatry, and Michael Swift, M.D., professorof pediatrics (both at New York Medical C...Fruit Flies May Shed Light On Cocaine Addiction
... people. It may also lay the foundation for highly specific drugs to treat cocaineaddiction. The research, performed by Dr. Jay Hirsh and Colleen McClung of the Universityof Virginia in Charlottesville, grew out of the group's long-term geneticstudies on brain receptors and neurotransmitters--such as dopamin...3-D Structure Of HIV Components May Pave The Way For New Anti-AIDS Drugs
...ts into how the protein recognizes and binds to [a specific siteon viral] RNA. Second, it provides a structur... plucksfrom the infected cellular melange only the specific viral RNA needed to formnew viral particles. Nucleocapsid recognizes and binds to only the few RNAs......accelerate our ongoing efforts todesign potent and specific drugs against hepatitis C," said Dr. Paul Caron,Vertex biophysicist and also an author of the Structure paper. "In addition toproviding information on a key target for therapeutic intervention, thestructural data we have unveiled also suggests a poss...Hurdle In Ulcer Vaccine Development Cleared
...c ulcers clingsto the stomach wall by locking onto specific receptors on cells in the gastriclining. Collaborators in Sweden and the United States now have identified andisolated a bacterial protein that allows the microbe to cling. "With this attachment protein in hand, it eventually should be possib...UMass Researchers Announce Birth Of Genetically Modified Cloned Calves
...lones. The newborn cloned transgenic calves have a specific gene which serves as a "marker" to confirm that they are the products of genetic engineering. The calves are notable because they lead the way to the production of similar animals that produce very large quantities of therapeutic human proteins, esse......nisms' genomes, for instance, or identification of specific cancer-related mutations. The new method of DNA production uses as its template a single piece of circular DNA far smaller than that found in eventhe tiniest of organisms. Like a molecular fishing reel, this tiny ring of DNA unfurls a long stra...