Researchers discover why mutant gene causes colon cancer
...ion of the APC gene is also found in 85 percent of sporadic colon cancer. Colon cancer is the number two cancer killer in the United States....From science fiction to reality: Nanomedicine brings fresh hope to the medical world
...through the skin are increasing. Although there is sporadic evidence supporting these possible hazards, it is essential for the nanomedicine community to take the lead in defining the risks associated with nanotechnology. Proactively supporting experts in risk communication can help avert a situation in which...Study yields insights into precancerous condition
... and possibly in other tumors that result from the sporadic loss of LKB1." Study co-authors include BIDMC researchers Reuben Shaw, PhD, Brendan Manning, PhD, and Monica Kosmatka, as well as Nabeel Bardeesy, PhD, Lyle Lopez, and Ronald DePinho, MD, of Dana-Farber Cancer Institute. This study was funded by gran...USC researcher named General Motors Cancer Research Scholar
... contribute to the development and progression of sporadic breast cancers. (Sporadic breast cancers are those that are not directly associated with a specific genetic mutation.) Rice's work at the Keck School is concentrated on so-called epigenetic gene regulation the heritable on and off switches of genes...Study sheds new light on genetic risk for Parkinson's disease
...he body."APOE-4 is a major susceptibility gene for sporadic and familial Alzheimer's disease and has been associated with poor clinical outcome in people with acute head injury and stroke," Huang said. "In the brain, apolipoprotein E-4 may be involved in neuron repair and in the removal of dead cells, so if y...Altered protein involved in a novel link to Alzheimer's disease
...tein called p25 may help explain the occurrence of sporadic Alzheimer's (as opposed to the less common familial form of the disease) and also why stroke and high blood pressure increase the likelihood of developing Alzheimer's. Dr. Li-Huei Tsai, a Howard Hughes Medical Institute investigator at Harvar...Study identifies which patients can benefit from targeted lung cancer drug and why
...t Iressa, an EGFR kinase blocker that has had only sporadic success against NSCLC, shrinks such tumors more frequently in Japanese patients than in Americans. Meanwhile, study co-authors Johnson and Janne found that tumor tissue from a woman with cancer that had spread to the lining around her lungs a condi...A&M researcher studying genes of mosquitoes
...e tropic and subtropics, and the disease occurs in sporadic outbreaks. Immunization is an effective preventive measure, Pietrantonio said. But, "the control of dengue is achieved by killing the vector, the mosquito," she said. "We need to know more about the weak points of the mosquito to find new ways of ...Other highlights in the March 3 issue of JNCI
...ldhood tumor of one or both eyes. The tumor can be sporadic or hereditary, the latter of which is associated in a mutation in the retinoblastoma 1 (RB1) gene. Compared with the general population, survivors of hereditary retinoblastoma have higher risks of early-onset second cancers, particularly sarcomas, br...New findings are a window into the late stages of 'Lou Gehrig's' disease
... also able to distinguish familial ALS (FALS) from sporadic ALS (SALS). They believe their approach can reveal...nal cords were obtained from five individuals with sporadic ALS and 2 with familial ALS. All samples were frozen and frozen tissues were dissected to separate ...Activation of receptor ups development of precancerous intestinal polyps
...atous polyposis (FAP) and is seen in 80 percent of sporadic colorectal cancers, so the mutation is highly rele...ecause the mutation occurs in the vast majority of sporadic colorectal tumors, individuals with pre-existing polyps who take PPAR-delta agonists may also be at ...Census finds mountain gorillas increasing
...h to conduct such a census. Facing the threats of sporadic insecurity and poaching, the mountain gorillas of the Virungas have climbed back from a low of approximately 260 individuals in 1978, when many believed the mountain gorilla would become extinct. When considered against the backdrop of regional insta...Autophagy active in tumor suppression
...onoallelically deleted in 40-75% of cases of human sporadic breast, ovarian, and prostate cancer. However, little is known about the role of autophagy in cancer biology. In the December 15 issue of the Journal of Clinical Investigation Beth Levine and colleagues studied a targeted mutant mouse model with a he...JCI table of contents, December 15 2003
...onoallelically deleted in 40-75% of cases of human sporadic breast, ovarian, and prostate cancer. However, little is known about the role of autophagy in cancer biology. In the December 15 issue of the Journal of Clinical Investigation Beth Levine and colleagues studied a targeted mutant mouse model with a he...Breast cancer susceptibility genes play role in DNA repair
...re part of BRCC and linked one of them, BRCC36, to sporadic breast cancers. "We know that BRCA1 and BRCA2 are... Shiekhattar and his colleagues found that certain sporadic breast tumors featured a profound increase in the amounts of BRCC36 protein. "While the mechanism is...Smallpox in Europe selected for genetic mutation that confers resistance to HIV infection
...n 1346 and 1352, bubonic plague was historically a sporadic disease with an average annual death rate of only a few percent during the 400-year period it afflicted Europe. Transmitted by fleas infesting rats, it killed people of all ages. Smallpox, on the other hand, was a continuous presence in Europe for 2,...High heart risk for lupus patients linked to death of cells lining blood vessels
...k normal tissues and organs. The disease can cause sporadic periods of fatigue, pain, organ damage and disability that persist for years. Many patients die prematurely of kidney failure, infection or cardiovascular diseases, such as heart attack or stroke. Even at a young age, many people with lupus have nar...Healthy neighbors rescue degenerating motor neurons
... cancer, in which there are hereditary cancers and sporadic cancers," he said. "And the mechanisms that are re...editary forms are very useful to understanding the sporadic forms." The major question, he said, is how mutant SOD1 contributes to ALS. "My colleague Don Clev...Two studies find Gulf War veterans have increased risk of ALS
...were diagnosed before age 45. All of the cases had sporadic (non-familial) ALS. "This study focused on people aged 45 or younger because there aren't enough people over 45 who served in the Gulf War and have ALS," said study author Robert W. Haley, MD, of the University of Texas Southwestern Medical Center at......ogenes and tumor suppressors genes, primarily from sporadic breast cancers (the most common form of the disease). These include PTEN and DBC2 (tumor suppressor genes frequently missing from or inactive in a large proportion of breast and other cancers) in addition to KCNK9 (a gene whose identification reveale...