Animal studies show promise treating severe chronic pain
..."That might seem like a radical departure from the standard paradigm of blocking protein receptors or desensitizing them to control pain, but our laboratory data, obtained from cells in a dish, was so compelling that we thought it just might work." As reported this month, Karai et al. performed a series of ex...Kinase backgrounder: Iressa discovery part of major kinase project at Dana-Farber
... as the wave of the future in cancer drugs. Unlike standard chemotherapy drugs, kinase inhibitors are so specific that they spare normal cells and tissues. As a result, their side effects are much milder, and they can be taken orally rather than needing to be injected into veins. In a more recent discovery, D...Kiratisin wins 2004 Dade MicroScan Young Investigator Award
...Institutes of Health (NIH), Kiratisin noticed that standard methods used to identify members of the viridans group of streptococci did not always accurately distinguish between different species in this large group of bacteria, many of which cause endocarditis and other serious infections in humans. Moreover,...Genetic signature may predict recurrence in colon cancer patients
...bject of an editorial in the Journal. While the standard of care for patients with Dukes' B, or Stage II, colon cancer surgical resection of the diseased tissue is considered highly effective, up to 20-30 percent of these patients can later develop recurrence and die from the disease. Patients classified...Brace therapy for osteoarthrisis, legal issues in TBI research, prosthetic fitting
...nt of the automated technique will make possible a standard method to evaluate tinnitus. Electrical stimulation inhibits bacterial growth, promises faster wound healing, pg 139 This study gives further evidence that electrical stimulation (ES) inhibits bacteria growth, enhancing wound-healing rates....Gene-based screen sorts cancer cases, say Stanford researchers
...ors know a patient isn't likely to respond well to standard therapy, the patient may be a candidate for novel ...s are usually tested in people who have failed the standard therapy," Levy said. "If you know in advance who won't respond well, you can treat them more aggress...University of Pittsburgh receives NIH funding to develop heart assist device for infants
...k of tubes and medical equipment. Despite it being standard practice for nearly 30 years for pediatric patients of all ages who are in heart failure, its use is associated with a high death rate. Less than half of children and infants survive the therapy. Larger children sometimes have the option of being sup...Scientists identify six genes associated with survival in diffuse large B cell lymphoma
...side the point of origin. While the IPI provides a standard way to evaluate cases of DLBCL, clinical outcomes among DLBCL patients with identical IPI values varyconsiderably. We look forward to further exploration of this model byreplicating the study in a larger and more diverse population. The ultimategoal...New analysis gives cancer patients personalized prognosis
...team then used this genomic information along with standard clinical factors to organize patients into categories representing different risk groups with respect to cancer recurrence. Their statistical method, utilizing so-called "classification trees," successively splits patients into ever smaller groups ha...Seabed secrets in English clay
...mingly incompatible creatures living together. The standard interpretation of the fossil record needed some refinement. "The animal fossils and bacteria organic matter, though contained in the same packet of rock, were not deposited at the same time," he said. "There was the deposition of organic matter ...Annotation marathon validates 21,037 human genes
... two years to complete, and is expected to set the standard for analysis of gene expression and human diseases worldwide through the publicly available H-Invitational database. There are estimated to be about 30,000 genes in humans, so having a detailed functional map of a majority of them will be a boon for ...Is a single bout of exercise helpful or harmful in getting a good night's sleep?
...characteristics (all values throughout are means + standard deviations) were as follows: Subjective measures of sleep were determined using the Pittsburgh Sleep Diary the two nights before the exercise bout and the night after the exercise bout. An objec...Rensselaer receives NIH grant to develop virtual surgery simulator
...ng. "If successful, this could become the de facto standard in surgical simulation technology," De said. After developing a successful prototype for minimally invasive surgery, De hopes to apply the model to a much wider class of medical procedures. "The grand vision," he said, "is to develop a palpable huma...Delirium high in ICU patients, leads to death, morbidity
...ated into seven languages and are recommended as a standard of care by the Society for Critical Care Medicine for all patients treated with mechanical ventilation. Thousands of institutions worldwide have contracted Ely's team to implement delirium monitoring, and many more have likely downloaded the materia...Researchers substitute whole chromosomes to speed the search for genes in common diseases
...titution, Dr. Nadeau and colleagues have set a new standard for the use of models to fully dissect human traits and disease. This is one of the most important and impressive body of work to have been done to date to unravel the genes underpinning complex disease." Nadeau's lab is making the mice available to ...Study reveals poor Houston air quality
...ed to more than 200 PPBs, far higher than the U.S. standard of 120. Zhang's findings are reported in the current issue of the Proceedings of the National Academy of Science. The reason for the high daytime rating, Zhang says, can be directly traced to the huge refineries and petrochemical complexes in the are...MCG pursues markers to improve ovarian cancer treatment, diagnosis
...d a co-investigator on the new study. With today's standard treatment, surgery to remove the tumor followed by chemotherapy, survival rates for late-stage ovarian cancer are 30 to 35 percent. Long-term, the researchers' quest for biomarkers may lead to better treatments by identifying specific proteins expres...Newer drugs more effective at curing strep throat than penicillin
...ol-age children. Penicillin is considered the gold standard for treating strep throat, but pediatricians should realize that cephalosporins are more effective in killing the germs, says Janet Casey, M.D., the study's lead author and a University of Rochester Medical Center pediatrician. Cephalosporin drugs s...First flavors form a lasting impression
... commercially-available infant formula. One was a standard milk-based formula. The second formula is called ...about two weeks of age, one group was fed only the standard formula while a second group received only the hydrolysate formula. Two additional groups combined ......gulation factors Factor VIII (FVIII) and FIX. The standard treatment is replacement of the missing proteins intravenously. Complications often arise, however, when patients develop antibodies to these clotting factors, neutralizing treatment. An alternative treatment is the infusion of a recombinant Factor...