SAGE-acious prediction of thyroid carcinoma
...d four genes (DDIT3, ARG2, ITM1, and C1orf24) with statistically significant gene expression differences between FTC and FTA. They used these differentially expressed genes as predictive markers for carcinoma in a series of patient cases. RT-PCR analysis of patient samples for the markers successfully predicted tu...Bay area to get unique x-ray microscopy resource
...he new TXM at the ALS will be able to accumulate a statistically significant volume of data within a relatively short time. Larabell and Le Gros have been using an existing TXM at the ALS to demonstrate the potential of using this technology in cell and molecular biology studies. The existing TXM, called XM-1, th...NIST-led research de-mystifies origins of 'junk' DNA
...Evolution . The results are based on a systematic, statistically rigorous analysis of publicly available genetic data carried out with bioinformatics software developed at CARB. In humans, there is so much apparent "junk" DNA (sections of the genome with no known function) that it takes up more space than the func...Other highlights of the March 17 issue of JNCI
...using the P value alone to declare a finding to be statistically significant is no longer appropriate for deciding ...n between a genetic variant and a disease, given a statistically significant association--to evaluate whether a finding is noteworthy. The authors conclude that this...Rimonbant shows promise in addressing multiple risk factors
...leting a year of treatment on rimonabant 20 mg was statistically significant (p<0.001 vs. placebo). Researchers... patients treated with rimonabant 20mg there was a statistically significant reduction (p=0.002 vs. placebo) in the proportion of small dense atherogenic LDL, which ...Antibiotics may not be necessary when treating children with a simple skin abscess
...justed. On further follow-up, researchers found no statistically significant differences with regard to fever or wound tenderness, discharge or size in patients whose antibiotic therapy was changed compared to those whose therapy was not changed to an effective antibiotic. Four patients were hospitalized on the in...Vitamins do little to prevent recurrent stroke
...tients on the high dose had a second stroke, which statistically is nearly identical. The study found that the vitamin therapy lowered levels of homocysteine an amino acid leading the investigators to say, "Findings in other trials of an association between total homocysteine with increased risk of stroke and he...Measuring perchlorate levels in lettuce
...this preliminary survey into a more comprehensive, statistically rigorous, geo-referenced study across a wider range of leafy vegetables over the next couple of seasons. Initial funding came from the Arizona Iceberg Lettuce Research Council and a cooperative agreement with the USDA-ARS (Agricultural Research Servi...European Virtual Institute for Genome Annotation receives 12 million Euro
... experimental work. "Experimental validation of a statistically significant subset of computational predictions will be an integral part of the process, leading to an iterative improvement in methods," explains Thornton.The annotations will be integrated using DAS (Distributed Annotation System), an Open Source s...Researchers develop computer application to 'read' medical literature, find data relationships
...entify general themes, Dr. Garner said, along with statistically exceptional groupings within the list (such as drugs affecting the activity of a group of genes). Researchers also can infer how cohesive an experimental grouping is based upon relationships documented in the literature and identify missing members i...BRCA mutations do not increase risk of colorectal cancer
...he results of DNA testing, U-M scientists found no statistically significant difference between the number of cancer patients with BRCA1 or BRCA2 mutations (24), and the number of non-cancer controls whose DNA contained one of these mutations (20). "We found no strong common genetic basis between colorectal and br...New findings can help parents looking to combat number of kids' sick days
...6 wk after). A minimum value of P 0.05 indicated a statistically significant result. Results The researchers found that: while there were no statistically significant differences between genders found in physical characteristics, significant differences w...Gene differences may alter susceptibility to multiple sclerosis
... increase in risk for MS. In addition, there was a statistically significant tendency for children with MS to have ...the difference between CD24a/a and CD24a/v was not statistically significant. "The evidence from this study, together with the evidence from our animal studies, stro...Newly identified genes may help predict outcome in childhood leukemia
... performed gene expression profiling in two large, statistically designed, retrospective groups of pediatric ALL patients registered to trials previously conducted by the Pediatric Oncology Group (now merged with other national groups into the Children's Oncology Group) a group of 127 infant leukemia patients and...New advances in thrombosis help further understanding of disease prevention
...ents on ximelagatran (22.5 percent). There was no statistically significant difference in safety between the two treatments. Ximelagatran provides better protection against venous thromboembolism without need for dose monitoring and with no increase in complications. ...Link between alcohol consumption and muscle damage in females
...for 1 day compared with fed rats, and there was no statistically significant effect on Bcl-2 mRNA in any of the experimental conditions. Conclusions Alcohol acutely increases c-myc mRNA in skeletal muscle, possibly reflecting a preapoptotic effect, a compensatory stimulus to induce hypertrophy to counter...A human hormone, combined with a full stomach, offers clues for understanding our food intake
...ake and duration, a probability of 0.05 was deemed statistically significant. The Bonferroni procedure was used for the questionnaires to adjust the significance level of the questionnaire data. Results Highlights of the results included the following observations: The combination of CCK and distension of 3...Pesticide delays sexual maturation
...ticular descent in the study group, but it was not statistically significant due to a small sample size. "Our study results suggest that endosulfan exposure may delay sexual maturity and interfere with hormone synthesis in male children," the study authors write. "The practice of aerial spraying of endosulfan was...Effects of maternal myasthenia gravis on pregnancy and birth examined
... birth defects, but that number was not considered statistically significant when compared with all births. Hoff said results of the study shouldn't discourage women with MG from giving birth, but that they should plan to have access to good medical care should complications arise. Neonatal deaths did not rise sig...Protein biomarkers accurately and quickly diagnose ALS, find Pittsburgh researchers
...rometry to characterize protein peaks that exhibit statistically significant alterations between ALS patients and the control groups, Dr. Bowser and his colleagues identified protein biomarkers that diagnose ALS with near 100 percent specificity and sensitivity. "Not only will a CSF-based test lead to faster diagn...