UT Southwestern receives $1.78 million grant for obesity research as part of NIH Roadmap initiative
...grant. "Hopefully, our efforts will provide bigger steps toward understanding the metabolic processes that lead to obesity and some of the metabolic syndromes commonly associated with obesity, such as cardiovascular disease, hypertension, diabetes and fatty liver disease." The Taskforce for Obesity Researc...Gene clusters predict atherosclerosis severity, susceptibility
...he researchers, this is an important first of many steps toward developing highly individualized approaches to identifying and treating atherosclerosis that are tailored to and informed by a patient's unique genetic make-up. Atherosclerosis is a disorder marked by the thickening and clogging of blood ve...Wisconsin scientists develop quick botox test
...om nerve endings - and interfering with any of the steps in the process can inhibit the poison's toxic action. "We can screen for (agents) to block any one of those steps," explains Chapman. "We could screen one million drugs at a time, and you can do all the screening using live cells." The potential upsh...First glimpse of DNA binding to viral enzyme
...and others have been working to understand all the steps necessary for this enzyme's function, looking for new ways to stop its action and, therefore, block an adenovirus infection (see: http://www.bnl.gov/discover/Spring_04/anti_viral_1.asp ). The scientists didn't expect the viral DNA to bind to the...AACR applauds NCI initiative on nanotechnology
To better understand the molecular steps that result in cancer and its spread, scientists and clinicians increasingly are turning to smaller and smaller probes that not only act as microscopic sentinels, but also as tools capable of interfering with these processes. For this reason, the Ame......chymal-epithelial transition represent significant steps toward a clearer comprehension of how cellular reorganizations are achieved during development. And with epithelial-mesenchymal transitions featuring in fundamental biological processes from organ development to cancer metastasis, such knowledge may ...OutFoxed! New research may redefine late-stage cardiac development
... develops in mammals. "Understanding the earliest steps in heart development gives us insight into the possible genetic causes of the dramatic heart defects exhibited by so many newborn babies, " says Morrisey. During normal embryonic development in mammals, pre-cardiac cells form the bilateral cardiac pr...Molecular staples shape a cancer killer
...cording to Walensky, the experiments are the first steps in a broader effort to construct hydrocarbon-stapled alpha-helical peptides that affect many control points of apoptosis. These are necessary because different cancers may have thwarted the apoptotic machinery in different ways, he said. "The goal w......ch Human cancers generally develop through several steps -- initiation, promotion, and progression -- which require the accumulation of between 4 to 6 genetic mutations. Skin cancer is the most common cancer for both men and women. John DiGiovanni and colleagues, at The University of Texas MD Anderson Can...JCI table of contents: 1 September, 2004
... Human cancers generally develop through several steps -- initiation, promotion, and progression -- which require the accumulation of between 4 to 6 genetic mutations. Skin cancer is the most common cancer for both men and women. John DiGiovanni and colleagues, at The University of Texas MD Anderson Can...The future of HIV therapeutics is brightening, according to Gladstone Institutes Director
...ine. These advances address but one of the three steps required for successful entry of the HIV virus. The other two steps involve the attachment of HIV virions to surface CD4 receptors and the final fusion of virions to ta...Environmental costs of home construction lower with wise choice, reuse of building materials
...st energy-intensive building materials and taking steps toward such things as recycling and reusing more building materials makes sense considering the nation's energy concerns and attendant issues of pollution and global warming, according to University of Washington's Bruce Lippke, professor of forest ...Researchers uncover secrets of immune system's munitions factory
...Alt. "We'd like to figure out how those downstream steps in these two different situations lead in one case... that we know more about how AID links to the next steps through RPA, we can begin to address this problem, which is a major question in the field."...... on one summer's night but with thousands of small steps spread out over the course of several years. The importance of solving the human genome and the genomes of other species is that those billions of letters of DNA are deposited into databases and become available to scientists everywhere to conduct...Embryonic stem cell therapy shows steady benefits in rebuilding infarcted heart
...iac death or tumor formation. Conclusion and next steps The researchers conclude that "embryonic stem cells, through differentiation within the host myocardium, can contribute to a stable beneficial outcome on contractile function and ventricular remodeling in the infarcted heart." Going a step further, ...JCI table of contents, 16 August, 2004
...In order for cancers to form, one of the molecular steps that must occur is for the tumor cells to develop the means to avoid being attacked by this defense mechanism. There are several different methods by which the immune system can eradicate tumors early in their development. One tumor immune surveilla...Medication reconciliation, pharmacist involvement vital to reducing medication errors, study finds
...rmacists perform medication reconciliation, taking steps to ensure patients receive the correct medication and accurate dosage, the number of medication errors dropped and with them the potential for patient injury. "A medication error, once in a patient's medical record, can carry-over from admission thr...MICs shed light on prostate cancer
...In order for cancers to form, one of the molecular steps that must occur is for the tumor cells to develop the means to avoid being attacked by this defense mechanism. There are several different methods by which the immune system can eradicate tumors early in their development. One tumor immune surveilla...Fundamental change to Immunology 101
...udy this cell, and a better understanding of early steps in T-cell development should follow." They describe their findings in the current advance online publication of Nature Immunology. Hematopoietic stem cells (HSCs) are the ultimate progenitors of all blood cell types, from platelets and red blo...Casanova or caveman: Scientists isolate nerve cells that choreograph male fly's courtship behavior
...s carried out the crucial task of coordinating the steps of the courtship ritual. When those cells didn't f...om the pupa." The courtship ritual consists of six steps carried out in a specific order. First, the male senses the presence of the female and follows her. ...