Tag: "steroid" at biology news
Select research highlights from current AACR journals
...edical Center, Durham, N.C. Two inhibitors of steroid
synthesis used to treat hormone-dependent breast cancer in postmenopausal women pack a significant beneficial side effect in laboratory animals. Exemestane and letrozole was shown to significantly prevent bone loss, enhance bone mechanical strength a...
Nevada researcher re-ignites mammal reproduction debate
... selected populations of wild mammals. An injected steroid
can block glucose circulation, and potentially increase the number of female offspring, while in the long term the same result may be accomplished through diet. Such a study would be able to show whether mammal populations in different regions could...
Ovarian cancer sheds tumor suppression with loss of estrogen receptor
...an cancers shed the restrictive properties of this steroid
receptor in the regulation of cell growth, death and motility. The loss of ER beta expression appears to be an important event leading to the development of ovarian cancer." Lazennec was joined in the ER beta studies by Aurlie Bardin, Pascale Hoffman...
New discovery may help transplants survive
...ction of corneal transplants, patients need to use steroid
drops which can cause glaucoma, cataract development, and infection -- for years. Even then, many corneal transplants fail, and their failure can cause devastating vision loss. If transplants are placed in eyes suffering from inflammation (caused by...
When male fish hum, females swim in, thanks to hormones, adaptable hearing
...ous experiments in other laboratories suggest that steroid
hormones may also play a role in causing some of the reported changes in hearing sensitivity of human females at differing stages of the menstrual cycle. Also humans have a natural loss of hearing in relationship to age. The higher frequencies tend ...
Hormone helps fish to mate, may affect human hearing
...he biologists experimentally boosted levels of the steroid
hormone in non-reproductive females of the fish sp...ogether we'll make beautiful small fry." Altering steroid
hormone levels did not change the reproductive status of the females; the eggs they carried were sti...
Most Americans not sure about the sources of high cholesterol
...cally important in helping to form cell membranes, steroid
hormones and bile acids. There are two sources of cholesterol: cholesterol comes from the food you eat and is produced naturally in the body. However, over time, excess LDL (or bad) cholesterol in the blood can build up on the inner walls of the a...
New study confirms process leading to disorder causing male characteristics in women
... Human studies of PCOS have found abnormal ovarian steroid
responses to administration of gonadial hormones, ... Methodology This study sought to assess ovarian steroid
secretion in response to near-physiological gonadotropin stimuli in 12 ovulatory controls and 7 wome...
Breast cancer patients failed by treatment with taxol and taxotere respond to abraxane
...oparticle paclitaxel), administered weekly without steroid
premedication, is active and well tolerated in women with metastatic breast cancer whose disease had progressed while they were treated with paclitaxel (Taxol) and/or docetaxel (Taxotere). Based on analysis to date, results showed a 15 percent (95% C...
New research shows that the seasons may be involved in onset of menopause
...ound in the ovaries and it also influences ovarian steroid
hormone production. Other research has shown that the harmony of these links becomes disrupted in parallel with a fall in melatonin levels in early peri-menopause. "The cessation of ovarian function is a process from regular towards irregular control...
APP reports Abraxane(TM) is active in breast cancer patients who failed taxol or taxotere
...hypersensitivity reactions, despite the absence of steroid
pre-medication, occurred," said Soon-Shiong. The company previously announced along with American BioScience Inc. that the New Drug Application (NDA) for ABRAXANE TM was accepted for filing by the U.S. Food and Drug Administration (FDA), indicating ...
Synthetic hormone used in contraceptives and HRT produces negative effects in monkey studies
...(MPA), a synthetic form of the naturally occurring steroid
hormone progesterone widely used in contraceptives and hormone replacement therapy (HRT), increases aggression and anxiety and reduces sexual activity in female monkeys, according to a study published in the June edition of The Journal of Clinical En...
Sex-specific differences in gene expression related to drug metabolism and hypertension
...entially expressed genes were involved in drug and steroid
metabolism and regulation of fluid balance. The results have interesting implications for explaining how males and females respond differently to drug treatments and sex-specific propensities for high blood pressure. Interestingly, the adult hypoth...
When 'reaper' gene comes, cell death follows
...s. Cell death (apoptosis) begins when ecdysone, a steroid
hormone, binds to its receptor, EcR/USP. This binding allows the receptor to activate three key regulatory genes--E93, BR-C, and E74A. Those genes turn on reaper and hid, which then deactivate the death inhibitor DIAP1. When DIAP1 is no longer functi...
Exercise reduces blood estrogens, risk for breast cancer in post menopausal women
...ogenic form of estrogen. Estradiol is a female sex steroid
with a more potent estrogenic effect than estrone, a different form of estrogen. Estrone concentrations are equivalent to estradiol levels in the blood prior to menopause, but normally increase in postmenopausal women. The moderately intensive exerc...
DHEA boosts growth rate of human neural stem cells
...an neural stem cells, exposed in a lab dish to the steroid
DHEA, exhibit a remarkable uptick in growth rates,...ure effect of DHEA," Svendsen says. "It's the only steroid
we tested that had such a direct effect on stem cell growth and new neuron formation," according to ...
Steroid-coated DNA represents new approach to gene delivery
PHILADELPHIA Coating DNA with a topical steroid
might make for more effective therapeutic gene del...rnal Gene Therapy , available online now. "The steroid
coating not only allows the gene to be taken up into a cell more easily, but the steroid
Asthma could be several diseases masquerading as one
...t different biological processes and mechanisms of steroid
resistance." The definition of these subsets could help guide diagnosis, treatment and future research. For example, since early-onset patients were more often allergic than late-onset patients, treatments would be more likely to include an anti-...
Can the mode of training affect the hormone response to different modes of exercise?
...-of-its-kind study attempts to determine the acute steroid
hormone response to endurance and resistance exercise bouts of equitable volume in subjects with differing training status. The newly released findings conclude that the circulating endogenous hormone profile is more dependent on exercise mode or int...
Scientists uncover novel role for estrogen in bone marrow
...pment. 3b-HSD encodes an enzyme that regulates all steroid
hormone biosynthesis. Thus, Dr. Todokoro and colleagues explored which steroid
hormones are produced in megakaryocyte cells. Much to their surprise, they found estrogen. Dr. Nagat...
1 2 3 4