Endostatin promising treatments for AIDS-related cancer
... to preventing blood vessels from forming, it also stops new tumors from developing. In the case of KS, endostatin appears to cut the communication between the tumor cells and two key growth factors VEGF and bFGF both important to the formation of new blood vessels and in the development of new tumors. I...Researchers find mechanism that may determine early blood cell fate
...o portions of target genes, which either starts or stops the gene activity. The researchers zeroed in first on GATA-2, which is required in significant levels for HSC to differentiate into intermediate blood cells called multi-potent progenitor cells. But the protein levels must go down before the progeni...Sleep disorders linked to faulty brain chemistry, study finds
...uctive sleep apnea, in which breathing temporarily stops or diminishes dozens or even hundreds of times during a person's sleep, may affect 3 percent of adults but goes undiagnosed in most of them. Its most notable symptoms are snoring and excessive daytime sleepiness, though it can also affect blood press...Human genes can predict AIDS progression rate
...ze those infected cells. Destroying infected cells stops pathogens from multiplying within those infected cells. HLAs come in several varieties, or types, and exhibit tremendous genetic diversity. Everyone carries different combinations of these proteins. This diversity ensures that no single pathogen can ...First evidence that genetic imprinting occurs at earliest stage in test tube-matured eggs
...' command, so they bind the tags together and this stops the unnecessary gene being switched on. Methylation is essential for normal development and organ function. If the process goes wrong it results in abnormalities and developmental diseases. When the researchers analysed the control oocytes t...Key regulatory enzyme is a molecular 'octopus'
...ng of a protein called beta arrestin. This protein stops further G protein signaling and acts as an adaptor and scaffolding that connects to other signaling molecules." Thus, the cellular "stop signal" not only turns off the G protein, but immediately tags the receptor for recycling into the cell interior ...Researchers find new way to trigger self-destruction of certain cancer cells
... presence of a protein called 4E-BP1. This protein stops the cell from using use some types of mRNA (the "decoded" form of DNA) to make proteins, including survival factors. 4E-BP1 is normally held in check by mTOR; so the cell continues to use mRNA to make proteins that are essential for proliferation. Ho...Injection prevents blinding blood vessel growth in mice
...cals have identified an experimental medicine that stops the blinding blood vessel growth associated with diabetic eye diseases and possibly macular degeneration in laboratory mice. By injecting a fused protein called VEGF-TRAP (R1R2) into the eyes or bloodstreams of mice, scientists halted new blood v...Tips from the Journals of the American Society for Microbiology
...nstration that eradication of the viral infections stops the progression of lung fibrosis." (Y. W. Tang, J. E. Johnson, P. J. Browning, R. A. Cruz-Gervis, A. Davis, B. S. Graham, K. L. Brigham, J. A. Oates Jr., J. E. Loyd, A. A. Stecenko. 2003. Herpesvirus DNA is consistently detected in lungs of patient...'Immortalized' cells enable researchers to grow human arteries
...e subunit) component of the enzyme telomerase that stops telomeres from shortening, and had shown that expression of hTERT permitted some human cells to continue to divide indefinitely, in effect making them immortal. Working with Niklason and Counter, then medical student Andy McKee found that when the hT...Hebrew University researcher wins prize for work leading to new anti-cancer drugs
...oliferation. It cycles between an "off" state that stops cell division, and an "on" state that drives cell division. What occurs in the mutant Ras is that it loses its inherent enzymatic activity that enables it to be "turned off." The switch therefore remains stuck in the active ("on") state, thus drivin...Copper chelation is a promising new therapy for clogged arteries
...py. Preventing the function of copper in the body stops arteries from reclogging following the mechanical stress of removing arterial obstructions through angioplasty. The therapy works by limiting the cellular export of growth factors and cytokines involved in this process. "This represents a major cont...Virus researchers close in on the secret life of DNA
...s make another protein that binds to the Z-DNA and stops the process... "The beauty of our system is that we can now ask those questions. What genes are induced if you infect with a wild-type virus, as opposed to what genes are induced if you infect with a virus that doesn't contain the Z-DNA binding prote...Gene newly identified by Columbia researchers may improve hair removal
... cycling that even inactivating it in a given area stops hair growth permanently in mice, Dr. Christiano says. According to Columbia Universitys technology transfer unit, Science & Technology Ventures, a start-up company, Skinetics Bioscience LLC, will form to develop hair-growth and hair-removal produ...Researchers discover effective method for killing prostate cancer cells
...o breathe. If we stop this protein, which in turn stops the growth of prostate cancer cells, we are one step closer to managing the spread and growth of cancer in the prostate." Recent understanding of the correlation between prolactin, a hormone produced by male and female pituitary glands, and how it ...Study of bacterial enzyme reveals one key to cancer cell survival
...ts call apoptosis. In some cancer cells, apoptosis stops working, which means the cancer cells don't die off. The cancer cells may never get the signal to die because of the peroxiredoxin enzyme. They found a correlation between this failure and too much peroxiredoxin, suggesting the two could be related....Fast changing gene drives species split
A gene that stops different species of fruit flies from interbreeding is evolving faster than other genes, according to researchers at the University of California, Davis, and the University of Cambridge in England. The findings may help scientists understand how new ...Researchers model evolution of influenza virus
...re and more diverse," he said. "Understanding what stops that happening was the key question posed in this study." To explore evolutionary dynamics, Ferguson and his colleagues developed a computer-intensive mathematical model that simulated mutation in individual genetic units, or codons, of the viral coa...The timing of hormone replacement therapy could be key to success
...f the therapy begins around the time that the body stops making its own estrogen," said Thomas B. Clarkson, D.V.M., of Wake Forest. "The question may not be if estrogen helps, but when is the optimum time to begin therapy." Clarkson, a professor of comparative medicine, and Richard H. Karas, M.D., Ph.D., ......ns. This raises problems for theories that revenge stops further aggression. "My hope is that somewhere down the road, we will use this knowledge to get around killing one another. War is the most costly thing in the world in terms of blood and treasure. We need to figure out why we have war before it ...