Researchers Report Emergence Of Antibiotic Resistance During Vancomycin Therapy
...oodstreaminfection caused by a multidrug-resistant strain of Staphylococcus aureus. Thereport, published in the Feb. 18 issue of the New England Journal of Medicine(NEJM), showed that the bacteria, which had decreased susceptibility tovancomycin, could be treated effectively with a combination of antibiotic...Researchers Find Fas Ligand Is Important In Blinding Disease
...,Ferguson and Kaplan took their experiments into a strain of mice used to studyinteractions between the two ...h of thoseblood vessels. But in the mouse strain deficient in Fas, the lpr mouse, new vesselsgrew about 44 percent of the time, and in those deficien...Mechanism For Fungal Adherence Found, Possible Key To Disease
.... Sundstrom's group used a strain of Candida in which the transglutaminase-binding protein had been removed and tested its ability to adhere to human oral mucosalcells. Without the protein, there was a five-fold red...Investigators Identify Suspect In Search For Stress-Sniffles Link
...cipants developed verified infection with the same strain of influenzaA virus. At the end of each day, the participants rated the severity of theirrespiratory symptoms -- sneezing, nasal congestion and discharge, sore throat,cough, malaise, headache, and chilliness. Their mucus production was measuredby c......same time, scientists experimenting with a curious strain of micethat are unresponsive to endotoxin reported that they identified that themissing gene in these mice was the TLR4 gene, further supporting the conceptthat Toll-like receptors and TLR4 are essential for endotoxin signaling incells. "Still, until......wth by more than 90%. Moreover, the VNP20009 TAPET strain is easily amenable to manufacture and pharmacologi...000 times less toxic than the wild-type Salmonella strain from which it is developed. Additionally, the studies showed that the TAPET bacteria were rapidly cl...... Normal mononuclear cells were infected with HIV-1 strain and later treated withLPS and p38 MAP Kinase. P38 MAP Kinase is a human enzyme involved in thesignaling pathways within cells. When activated, the p38 MAP Kinase alsotriggers the production of cytokines that launch an inflammatory immuneresponse. Acc...Breakthrough On Microbial Disease Published In Science
...sdown, you're dead." Mahan's new mutated strain of Salmonella, with the master switchon, now shows all its "cards," its tricks for getting past the gut and intoorgans and tissues. "This has two important consequences," Mahan said, "thebacteria are completely disabled in their ability to cause di...Montana Hantavirus Study Looks At Why The Mouse Goes Into The House
...lit will work in different places. Patagonia has a strain of hantavirus called...Experimental Staph Vaccine Broadly Protective In Animal Studies
...kville, Md.,are sequencing a methicillin-resistant strain while a research team at theOklahoma University Health Science Center is sequencing a strain that remainssensitive to antibiotics. These projects should help scientists identify S.aureus genes...NIAAA-led study verifies environment-dependent behavioral variation in genetically identical mice
...sts using seven genetic mouse strains and a mutant strain thatlacks a single neurotransmitter receptor gene....epending on where they were tested,with the mutant strain evidencing the greatest degree of difference at theseparate sites. "Our hope is to generate discussi...... the experiment. The new techniqueplaces much less strain on the animal than conventional methods and makes itunnecessary to put them to sleep after the experiment. The improved method made it possible to visualize brain volumes as small as 0.5microliters in anesthetized monkeys and 2 microliters in a contr...Transplanted neural stem cells migrate throughout the abnormal brain, reduce disease symptoms
...the brain ventricles of newborn mice from a mutant strain thatdevelops severe tremors by 2 to 3 weeks of age. The tremor develops because themice lack a key protein needed to make myelin, the insulating coating thatsurrounds nerve fibers. The lack of normal myelin in these mice mimics thedefect seen in ma...Study points to possible gene therapy cure for hemophilia
... factor VIII levels up to 20percent of normal in a strain of healthy mice and factor VIII "knockout mice," astrain genetically bred without the gene for the clotting protein. "Although the [blood] levels of factor VIII are not at 100 percnet usingAAV gene transfer, they would be clinically benefici......same time, scientists experimenting with a curious strain ofmice that are unresponsive to endotoxin reported that they identified thatthe missing gene in these mice was the TLR4 gene, further supporting theconcept that Toll-like receptors and TLR4 are essential for endotoxinsignaling in cells. "Still, until...New study finds link between decline in the city's TB rates and intensified control programs
...out 1,500 cases. A person infectedwith a specific strain of TB that was noted in two or more persons within aone-year interval was defined as being part of a cluster. High-risk groups forclustering include persons born in the U.S. and those with HIV....Scientists target microbe with sleeker antisense agent
...und, just a few nucleotides long, that targets the strain ofpneumonia which kills many AIDS patients and others with weakened immunesystems. While the compound is in its earliest stages of development, scientistsbelieve the work marks one step toward an era when tiny artificial RNA moleculesact as selective...Ecotourism: Penguins can get used to people
Having houseguests can be a strain but new research shows that penguins canquickly adapt to the stress of ecotourism. Experimental evidence that wildpenguins get used to people visiting their breeding colony was presented byBrian Walker of the University of Washington in Seattle at th...H.pylori bacteria and their human hosts
...stomach at the same time---but not for long. "One strain willalways be dominant over the other," Kirschner ...chconditions can create advantages for a different strain and allows it topredominate." Kirschner added that H. pylori's ability to live in such close, long-t...Scientists clear hurdle in effort to destroy experimental brain cancers with viruses
...sponse. Inhibiting this responseallowed a modified strain of herpes simplex virus to reach the brain tumors, enabling it to attack--and in some cases destroy--thetumors. The study is published in the August Nature Medicine. "This treatment is more efficient than anything we have done before," says Chiocca, ...