Lab experiments reveal potential therapeutic target for degenerative brain diseases
...that the PrP from the mouse, hamster, and a second strain of mouse all sharedthe same core region. This shared section of the PrP inhibited conversion ofnormal PrP to abnormal PrP in both rodent species. "In our experiments, we showed that adding a peptide derived from the core ofthe prion protein dramatic...K-State veterinarian issues canine 'toxic shock' advisory
...erstood. Research is underwayto determine if a new strain has recently emerged or if the disease has suddenlybecome more common for some other reason. Currently there is no vaccine to prevent the disease. Fenwick said developmentof a reliable vaccine will likely be difficult because of the toxins'interferen......ppetite, Yanagisawa and his colleagues developed a strain ofknockout mice whose orexin genes do not function properly. After raising severalgenerations of the mice, the investigators videotaped the animals as they wentabout their daily business, hoping to see how the genetic alteration changedtheir behavior...Scientists image key steps in bacterial infection
... work. Hultgren's lab prepared the proteins from a strain of E.coli that infects the bladder. "The structure of the chaperone-adhesin complextells us a story that is far more interesting than we ever could have imagined,"Knight says. "Hypothetically, it could be the beginning of a new book onmacromolecular ...Hepatitis E virus infection may be widespread in rats
... the absence of disease is due to infection with a strain ofHEV that doesn't cause disease. Another possibi... Dr. Purcell. "A major question is whether theHEV strain infecting rats is a new strain unique to rats or a variant of alreadyrecognized HEV strains." To ans...Genetic variation in sensitivity to estrogen may mask endocrine disruption
...rther evidence that the highly prolific CD-1 strain of mice is much moreresistant to the endocrine-dis...to endocrinedisruption by estrogen than B6 and C17 strain mice," Spearow said."Furthermore, extrapolation of the CD-1 data suggests that this line ofmice is a...'Knockout' mouse may lead to major understanding of human kidney disorder
...o thought it might benecessary to develop a second strain of mice that had low levels of uteroglobinbut that were not totally deficient in the protein. "We feared that mice lacking the functional uteroglobin gene might dieduring their early fetal stages," said NICHD's Zhongjian Zhang, Ph.D., aco-aut...Genome tools pass big test in fruit flies
...,600 vitalgenes. The researchers examined each fly strain for obvious changes fromwild-type flies, including phenotypes such as lethality, near-lethality andother readily apparent physical abnormalities. "Our goal was not to identify every gene we could, but to show that it wasfeasible to generate large nu......eir environmentand to retain that knowledge. This strain of mice, named Doogie, also retainedinto adulthood...ctions betweenneurons. Tsien's group named the new strain of mice "Doogie" after theprecocious character on the television show "Doogie Howser, MD." In studyi...Media Advisory: The Geological Society of America 1999 Annual Meeting
...boundary observatory thatwill continuously monitor strain at a large number of sites in the western U. S. It also includes a San Andreas fault zone observatory-at-depth for monitoringseismicity, strain, and pore pressure within the fault. A third component,USArray, is a dense array of high-capability seis......virus revealed that about one in sixwas carrying a strain that is resistant to at least one of the drugs tar...tage of patients in the group carrying a resistant strain was significant.The researchers found that viruses resistant to more than one drug were muchless com...Stressed-out mice offer clues to depression, anxiety, anorexia
...and anorexia. U-M scientists created the new mouse strain by deleting a gene that controlsproduction of one protein. This protein binds to corticotropin-releasinghormone or CRH, a key neuroregulatory hormone produced by all mammals understress. Binding prevents CRH from activating receptors that trigger t...Researchers discover location of a testicular cancer gene
...tics, isbased on research in 129/Sv mice, the only strain of mice to get spontaneoustesticular cancer. ...ew testicular cancer susceptibility gene. This new strain withits high frequency of testicular cancer is also the long-sought model forunderstanding the basis...Researchers identify enzyme essential for battle against bacteria in the intestine
...y at Vanderbilt University, Wilson had developed a strain of knockoutmice lacking this enzyme. The researchers focused on the small intestine, whichin normal mice produces high levels of matrilysin. The cells at the base of thesmall intestinal crypts -- called Paneth cells -- are believed to be defense cell...Great increase seen in antibiotic-resistant bacteria in human colon
... cheaply. Salyers' lab focused on Bacteroides -- a strain of bacteria not harmful in thelower intestines but the cause of often life-threatening infection when theyescape during surgery or trauma. Bacteria, she said, have produced a blueprintfor resistance that can be used to spread resistance to newer ant...Seeing one weapon from a food-borne pathogen
...realized he had made an important discovery when a strain of the laboratorybacterium harboring a single Y. pseudotuberculosis gene had acquired theability to enter animal cells. "This single gene ( inv ), and the invasinprotein it coded for, was sufficient for infection of cells in culture," Isbergsaid. ...Argonne biochips may halt tuberculosis epidemic
...each is resistantto different drugs. Finding which strain is affecting a patient, and knowingwhich antibiotic is best equipped to combat that strain, is key to controllingthe disease. Argonne will use the biochip technology in research to distinguish betweendifferent tuberculosis strains. The tests will be ...Genetic information of world's most radiation-resistant organism decoded
...lle, MD - No, it's not the cockroach, but rather a strain of pink bacteria that can survive 1.5 million rads of gamma irradiation - a dose 3,000 times the amount that would kill a human. This dose of radiation shreds the bacteria's genome into hundreds of pieces. The organism's remarkable ability to repai...New transgenic mouse likely to advance Alzheimer's disease research
A new strain of mice develops, with age, damaging tangles of a ...ay at Penn to cross the tau mouse with an existing strain of mice that develops beta amyloid plaques to produce a mouse that would even more closely mimic Alz...