How an insidious mutation fools DNA replication
... cytosine, and an adenine with a thymine. However, stray reactive oxidizing molecules in the cell can alter guanine to become an "8-oxoguanine" that can lead to a mismatch. This mismatch occurs in the process of replicating DNA, which begins when the two strands unzip. A protein enzyme called DNA polymeras......dence it contains any undesirable elements such as stray genes. But before Chromos or anyone else can move to human trials, says Huntington Willard of Duke University in Durham, North Carolina, they will have to run a series of rigorous studies to prove that their product is stable and consistently churns...Growing human organs on the farm
...l human cells, they would not be rejected. And any stray animal cells would be killed off by the recipient's immune system. Of course, the idea of using part-human, part-animal chimeras as living factories for producing cells or organs raises a host of ethical and safety issues. There is the risk of trans...Firefly molecule could quickly shed light on how well new drugs work
...chamber at ultra-cold temperatures to keep out all stray energy, produced vivid images showing the intensity of light -- and therefore the rate of cell death -- in different regions of the cell cultures or mouse cancer tumors. Rehemtullah notes that the technology is sensitive enough to pick up cell death ...First potentially clinically useful independent marker for lung cancer identified
...e repair gene will swing into action against these stray secondary cells. Because it is so early in the cancer process, it will have a good chance of repairing the damage and stopping the relapse of the cancer before the cells run out of control. If ERCC1 levels are low, there is less chance the rogue cell...MIGRATING ducks and stray tumbleweeds have been contaminated with radioactivity after landing fleetingly in ponds of waste water at a nuclear facility in the US. The news raises questions about the practice of leaving such ponds open to the elements. In the mid-1990s, sta......p excess fluid as well as molecules and cells that stray from nearby blood vessels. As with other organs, development of the lymph system is tightly regulated. One protein involved in the process is VEGF-C, which binds to its receptor, VEGFR3, on the surface of cells lining lymph vessels. In response, VE...Antbird capable of increasing testosterone level when threatened
...k-eyed juncos -- a temperate, migrating species -- stray from their mates andcare-giving duties when given large doses of the hormone. "We want to find out how aggression is regulated and what factors influenceaggressiveness," Wikelski said. "Birds are good models, because they are easy toobserve, as oppos...New Monitoring Technique Checks Thyroid Cancer Without Misery
...The test relies on the researchers' discovery that stray human thyroidcells can circulate in the bloodstrea...low level gene activity -- the sort you'dfind with stray cells -- to the point where it can be detected. "The techniqueis extremely sensitive. It can tell,...Veterinary Researchers Identify Accomplice Of Calf-Killing Parasite
...ttle management strategies designed to keep petand stray dogs from defecating in dairy feedlots or pastures...ity ashost organisms. Besides domestic and stray dogs, coyotes and foxes are also believed toharbor the organism, Lindsay said. While the di...Russian Queens Bee-Little Mites' Impact
...ved treatment, "they're gone." Though swarms that stray from beekeepers' colonies may survive a few months in the wild, he says, these days "they're doomed, too." The parasites develop on bee pupae. Once a bee emerges as an adult, it normally lives 30 days or more, depending upon how hard it works. B...Vaccine Kills Spreading Cancer In Animal Model
...ice, canalert the immune system to the presence of stray cancer cells and significantlyreduce their blood-borne spread. "Metastatic cancer, or cancer that is spreading from its site of origin,is among the toughest stages of cancer to treat," says Hongxiu Ji, M.D.,postdoctoral fellow. "Our findings...Biotech Approach To Feral Cat Problem Devised
...erts estimate that anywhere from 30- to 60-million stray cats roam the United States, according to second-year student Michelle Meister-Weisbarth. These feral cats are wreaking havoc on the nation's songbird population and raising public health concerns as they spread infectious diseases and alter delicat...High Testosterone Level May Lead Male Junco To Stray From Mate
...Ohio -- What makes a normally monogamous male bird stray fromhis mate to copulate with neighboring females? High levels of testosterone may be part of the answer, according to anew study. Researchers found that male dark-eyed juncos that were givenextra testosterone during the breeding season were more li...Herpes-Based Gene Therapy Is Key To Promising Liver Tumor Vaccine
...e sheer numbers of these cells should wipe out any stray cancer cells that escaped the surgeon's knife. A compound that does this, such as the vaccine cocktail put together by Drs. Federoff and Fong, is known as an autologous tumor vaccine. "We're trying to exploit the immune system's ability to specifical...Herpes-Based Gene Therapy Is Key To Promising Liver Tumor Vaccine
...he sheer numbers of these cells should wipeout any stray cancer cells that escaped the surgeon's knife. Acompound that does this, such as the vaccine cocktail puttogether by Drs. Federoff and Fong, is known as an autologoustumor vaccine. "We're trying to exploit the immune system's ability tospecifica...