Alzheimer's disease is not accelerated aging
...n-demented aging, Buckner reviews studies that use structural magnetic resonance imaging (MRI) images to link white matter lesions in the anterior part of the brain with the severity of cognitive dysfunction. Hypertension and accompanying vascular compromise is a salient predictor of white-matter damage. Other ...Safety of isoflavones in dietary supplements targeted by Illinois initiative
...lecular and integrative physiology and of cell and structural biology, will study patterns of gene activation affected by isoflavones through both estrogen-dependent and estrogen-independent receptors in breast tumors. They also will examine gene regulation in breast tumor systems, especially those adapted to ...Cardiac arrest may hinder ability to learn certain tasks
...s that do survive a heart attack may undergo major structural changes that can affect learning, memory and other behaviors, said Courtney DeVries, the study's lead author and an assistant professor of psychology and neuroscience at Ohio State University. Indeed, in the current study the mice that had had a h...University of Alberta researcher looks for clues to mysterious disease
...r investigating the basic mechanisms of chromosome structural maintenance involving ATM, allowing us to study how ATM works in a meaningful developmental context." Although a cure seems to be a long way off, using this system to understand more about how ATM works will offer more clues to treating the di...Resveratrol synthase uncovered: Cyclization specificity of type III polyketide synthases
A group from the Salk institute illuminates the structural basis for tetraketide cyclization in stilbene synt...Joseph Noel at the Salk Institute has revealed the structural basis for the specificity of this critical reaction. To do this, the Noel group generated the first ...Human chromosome 5 final sequence analysis released to public
...uman and chimpanzee chromosomes compared have some structural differences, including one large section that is flipped backwards in humans compared to chimps. Such an inversion makes it impossible for the two chromosomes to pair up when the cell divides to create sperm and eggs. Over time, that incompatibility ...Protein is key to fatal disorder and normal cell function
...cln3 protein lacks the amino acids that serve as a structural binding site for GalCer. In mutant patient cells, both cln3 and GalCer remain trapped in the Golgi and never move into the cell's plasma membrane, the Duke team discovered. With GalCer missing from the lipid platforms at the cell surface, apoptosis i...Peering inside the body, with a new spinliterally
...e oriented in this so-called magic angle, the more structural detail they obtained. "This was very fast spinning, an ultra-centrifuge, thousands of rotations per second," Wind said. "If you tried that with intact tissue or a live animal, you'd blow up your bio-sample and kill the subject." But what if you could...Genetically modified bacterium as remedy for intestinal diseases
...construction of the stomach-intestinal tract. This structural function ensures that TFF never arrives in the intestine through oral administration, because along the way it attaches itself somewhere in the stomach-intestinal tract. This was also demonstrated in the tests on mice with acute enteritis: oral admin...TANGO: towards faster prognosis of Alzheimer's and Parkinson's diseases?
...versal mechanism lies behind this process. Certain structural characteristics in proteins determine their susceptibility to sticking together. Using this information, Joost Schymkowitz and Frederic Rousseau have developed TANGO, a mathematical algorithm that looks at a large amount of data - including alterati...First glimpse of DNA binding to viral enzyme
...chnique recently developed at Einstein that allows structural information on the contacting surfaces of biological molecules to be precisely mapped. These contact points are regions providing critical communication in the cell," Chance explained. "In this study the footprinting approach provided information on ...Laboratory grows world record length carbon nanotube
...t are more than 10 times stronger than any current structural material. In addition to uses in lightweight, high-strength applications, these new long metallic nanotubes also will enable new types of nanoscale electro-mechanical systems such as micro-electric motors, nanoscale diodes, and nanoconducting cable f...Tufts University establishes $4 million dollar tissue engineering resource center
...water content and thus silk protein solubility and structural organization in their glands. This finding published in the journal Nature could lead to the development of new processing methods resulting in new high-strength and high-performance materials used for biomedical applications. In 2002, Kap......distinct ways, with epithelium being the essential structural and physiological component of organs and tissues such as the kidney and the lining of the gut, and mesenchyme forming all migratory cells, including metastatic cancer cells, as well providing support for the epithelium in various contexts. Despite (...Cell's gatekeeper for ammonia revealed in unprecedented detail
...a excretion via the kidney," Stroud explained. The structural basis for ammonia transport by AmtB is essentially the same for the human Rh factors, where small differences in the amino acid sequences of the conducting machinery lead to slight differences in their channels and provide for regulation and localiza...Story tips from the Department of Energy's Oak Ridge National Laboratory, September 2004
...searchers studied its transformation from a simple structural motif with four oxygen atoms surrounding a germani...uter simulation of molecular motions, to study the structural changes in more detail than ever before. This class of glass includes silica (SiO2), an abundant com...Battle between bubbles might have started evolution
... was based on the idea of the initial evolution of structural RNAs or ribozymes -- enzymes that could synthesize...s might have made more membrane material while the structural RNAs might have formed a cytoskeleton that influenced stability, shape, growth or division, he said....A genetic disorder yields insight into genes and cognition
...sal stream of the visual cortex. Higher-resolution structural MRI imaging revealed a reduction in the volume of gray matter in an adjacent brain region. The researchers' studies also showed that impaired input from this region could cause the reduced function. The researchers concluded that "Our observations co...Rare deficit maps thinking circuitry
...on tasks that activated the "what" circuit. Using structural MRI, the researchers found a small region early in the "where" circuit that lacked gray matter (neuron bodies) in the Williams Syndrome participants. Its location conspicuously just before the functionally abnormal areas raised suspicions; and a pa...New genetic research demonstrates possible cause of inherited form of Parkinson's disease
...o, M.D., Ph.D., assistant professor of anatomy and structural biology at Albert Einstein College of Medicine and the study's lead author, Dr. Sulzer is now using the study's findings to examine whether a backup at the protein disposal sites also plays a key role in the most common idiopathic form of Parkinson's...