Blood Test Can Identify Some Children With Strep-Related Behavioral Disorders
...dy's second author.But the findings suggest that a subset of children exist--those who may begenetically predisposed to involuntary actions of OCD and tics--whose suddenand acute onset is associated with strep throat. This allows clinicians toconsider prevention of the abrupt appearance of OCD and tic disor...Herpes Virus Strain Identified As A Trigger In Multiple Sclerosis
...ars, reactivates, accounting for its presence in a subset of MS patients.The study appears in the December 1997 issue of Nature Medicine(1). "We expect that currently available antiviral treatments--for example,acyclovir--might one day be applied successfully to MS," said Steven Jacobson,Ph.D., Chief of th......he researchers use a specific antibody todeplete a subset of T-cells, which are the cells responsible for cell-mediatedimmunity, the mice heal perfectly. "It is intriguing to speculate," says Dr. Heber-Katz, "that repair of woundsbecame dominant in mammals with the development of a complex immune system,w...Candidate Regulator Of The Temporal Component Of Neurotransmitter Release Identified
...ted the site of action of the NSF-peptides to a subset of synaptic vesicles that are located directly at the presynaptic plasma membrane and being prepared ("primed") for fusion. While neuronal communication relies on both the extent and duration of synaptic transmission, only the mole...Researchers Identify A Gene That Causes Juvenile Polyposis
...progress. "We know that this gene causes FJP in a subset of families, but we also knowthat it doesn't cause it in all families," Howe says. "The incidence may be aslow as 20 percent or as high as 55 percent. There are clearly other genes whichmay cause FJP." The next phase of this study is to determine i...UB Researcher Developing Method That Employs "Evolution" To Identify New Drug Leads
...continually reforms itself, evolving a much larger subset of effective components. These components then are isolated from the mixture and analyzed to identify potential drug leads. The method has been proven in a model system. The UB scientists are using it to develop drug candidates against the enzyme pep...Brain Antibodies Provide New Clues To Origins Of Tourette's
...fection may go on to attack brain nerve cells in a subset of thechildren who develop Tourette's," says Harvey Singer, M.D., professor ofneurology and pediatrics, and lead author of a study in the June issue ofNeurology. "The bacteria streptococcus is a leading suspect, but the search fora triggering factor ......atic lipogenesis supported the hypothesis that the subset of wasting patientswhose FFM is unresponsive to nutrient supplementation have altered nutrient metabolism....Ecological Consequences Of Jasmonate-Induced Responses For Plants In Native Populations
... more of their leaf area to herbivores; in this subset of attacked plant pairs, Jasmonate-treated plants matured 8 capsules and 537 viable seeds more than their control counterparts. In 13 pairs, only the jasmonate-treated member of the pair was similarly attacked, and in these, viable seed p......participate in a pathway that activates a specific subset of genes. Theseregulatory factors act in concert to control theabundance of proteins found in slow, oxidative skeletal-muscle fiberscharacteristic of highly fit endurance athletes. When a muscle is tonicallyactive, during jogging for example, the co......sonic echolocation calls of bats, a key predator.A subset of this group, more recently evolved, can also produce calls in thebats' own frequency, essentially jamming their predators' radar. Even furtheralong the family tree are moths that have adapted this sensory channel forcommunication between the sexes,...Cubist Pharmaceuticals Describes New VITA™ Technology For Enabling Genomics For Drug Discovery
...tested from adiverse protein target collection. A subset of the peptides was shown to becompetitive inhibitors of the targets. Potent, nM level inhibitors thatdisplaced the bound peptide were identified in a competitive binding screeningassay. These same inhibitors were also shown to inhibit the enzymati...Serotonin May Be Better Target For Attention Deficit Hyperactivity Disorder Treatment
...with a veryspecific compound that targets a single subset of receptors." While Prozac®calmed hyperactivity in the knockout mice, Gainetdinov says that "Prozac®isn't the best, because it isn't very selective." Caron and Gainetdinov areoptimistic that a new generation of compounds that interact more s...Little-Explored African Genetic Diversity May Hold Key To Human Origins, Medical Questions
...e Advancement of Science in Anaheim. "Only a small subset ofthe diversity in Africa is found in Europe and the Middle East, and an evennarrower set is found in American Indians." The researchers were looking at genetic information that is inheritedfrom both the mother and the father, and exists on...Programmable Cells Open Window Of Opportunity For Gene Therapy
...naturally expressive," because it readies a select subset of genes from thegenome for expression. The fate of the cell, then, is determined by therepertoire of these readied, or "potentiated" genes. Dr. Krawetz's main task was to determine how this mechanism "potentiation"arises. He began to look at several...UCSD And NIH Researchers Isolate Candidates For Genetic Basis Of Human Taste
...ste receptors. They arespecifically localized in a subset of taste neurons in the tongue--and nowhereelse--and are positioned in just the right place in these cells. These candidatetaste receptors resemble the receptors that mediate sensory processes such asvision and olfaction. This work has opened new vis...Researchers Discover Genetic Mutation For Rare Form Of Dwarfism
...ctive pathway, theresearchers have been treating a subset of the population with recombinant humangrowth hormone. Each patient showed a brisk increase in speed of growth. Levine and his colleagues are continuing their search for the cause ofgigantism. The work was supported in part by the N......hort term, buried within that group of people is a subset ofpeople who are really salt-sensitive." The exact cause of high blood pressure is not completely understood, says Flack. It has been well documented that when exposed to usual and customary levels ofdietary salt intake, blood pressure rises in some ...New Gene May Play Important Role In Regulating HDL, The 'Good' Cholesterol
... metabolism. It isproduced by endothelial cells, a subset of cells that includes those that linevessels and arteries, and is called endothelial lipase (EL). Researchers at Rhone-Poulenc Rorer, led by Michael Jaye, PhD, a senior scientistat the company and lead author on the study, originally purified the EL...Scientists Discover Important Molecular Link That Allows Cells To Form Blood Vessels
...at blood vessels supporting tumors express a small subset ofthese 'address recognition machines.' Molecular antagonists that might blockonly one but not the whole class of receptors should offer very high specificityand avoid potentially serious complications that would occur if all angiogenesiswere blocked...