Computers have had dramatic impact on chemistry
...advocating dispensing with original documents. The subtle questionis "What is original data?"." Pharmaceutical firms normally have to keep original data seven to 10 years, "butthey actually keep it forever because they don't know what will happen," saysDessy. "If they are sued, for example, records may pro...Disconnecting molecular handbrakes has drastic consequences
...whether SOCS1 isinvolved." Also, he said, more subtle SOCS1 malfunctions may powerfully affectthe immune system. "When you knock out a gene, as we did with SOCS1 , yousee the black and white of its function. But what if there are people withmutations that make their SOCS1 a little bit less efficien...Asthma-linked genes discovered at Berkeley lab
...e (mice that carry human genes) andfound that even subtle changes in the activity of the interleukin genes IL4 andIL13 can have an important effect on asthma susceptibility. Their researchresults were reported in the October 1 issue of the journal Nature Genetics. More than 14 million people in the United ...Penny wise and pound-foolish: Study shows need for second pathologist's opinion
... in patients' therapy or in their prognosis. More subtle disparities, such as saying a particular type of cancer was somewhat more advanced, weren't part of the study. In 23 percent of the suspect cases, patients' diagnoses changed from decidedly malignant to decidedly benign, Epstein says. "In...El Niño's dramatic impact on ocean biology and carbon dioxide captured by unique monitoring system
...another ocean-monitoring tool capable of detecting subtle changes in ocean color that are directly related to the concentration of chlorophyll, a prime indicator of biological activity in ocean waters. "This is the first time we've ever had a continuous set of biological measurements from moored instrument...Rapid size change in introduced fruit fly indicates it is evolving as it invades North America
...ent. Even so, the two continental populations show subtle differences in the part of the wing that lengthens with increased latitude. European flies have what could be called longer "biceps" while North American flies have longer "forearms." Stocks of South American D. subobscura recently were obtained bu...Why muscle strength seeps away: a new cause for muscular dystrophy
...not previously implicated in muscle diseases. The subtle disturbance of muscle fibre architecture identified in three Brasilian families may play an important role in other patients with similar disorders including age-related deterioration of heart and limb-girdle muscles. Identification of telethonin as ...Formosan termite may be top concern of entomologists of the new millenium, according to report
...th the use of genetically modified crops. But more subtle effects are harder to predict." The spread of emerging and resurgent insect-borne diseases has a number of causes. In some cases, the spread can be associated with ecological changes that have favored increasing insect populations. These, said Hunter......rt of the brain causing them. They also found that subtle jerkiness in movements may appear in HD patients long before clinical symptoms of the disease are first seen, perhaps providing physicians with a new diagnostic tool for early HD. According to a study published in the February 3 issue of Nature...Fossil plants' ties to ancient carbon redefined
...le through geologic time," she notes. "It's a more subtle question than how much CO2 is in the atmosphere, but it's closer to the heart of what we want to know about how carbon inhabits chemical spheres of the earth, and how that affects climate." Data on the plants and their environments revealed a numbe...Discovery of taste receptors may make bitter a bygone taste
...mino acids making up the receptor. This seemingly subtle difference in receptor structure determined whether or not the mice could recognize a bitter chemical. While humans can identify a wide range of bitter compounds, they all taste pretty much the same. This observation may be explained by another disc...... "The computer system we developed captures these subtle changes in the heart rate pattern." To develop th...eloped a mathematical algorithm that detects these subtle changes in electrocardiographic recordings. "Gradual changes in cardiac cycle dynamics could lead to...Researchers identify novel penicillin-resistance gene in pneumonia bacteria
...the penicillin-resistant pneumococci had undergone subtle alterations in their DNA blueprints, reducing the ability of PBPs to bind penicillin, thus providing penicillin resistance to the bacteria. By 1990, Tomasz and former Rockefeller postdoctoral fellow Jose Garcia-Bustos, Ph.D., discovered that the res...Virtual reality tool quantifies physics of a doctor's touch
...ls he or she has, allowing the physician to detect subtle signs of disease or injury just by touching a patient. Exercising that expertise always has required the presence of two individuals in the same physical space at the same time: doctor and patient. Until now. University at Buffalo researchers are d...Unexplained infertility -- the way forward in the fog
...step though was careful evaluation to make sure no subtle causes of infertility had been overlooked -- conditions such as inflammation of the cervix or lining of the womb, antibodies to the sperm or problems involving implantation of the embryo immediately after fertilisation Then treatment should follow fi......suicide have a distinctive tone of voice A subtle change in the sound of someone's voice is the first sign that they are serious about committing suicide. The change is so distinctive that psychiatrists plan to use the sound change as an early warning system to separate those who are ......oyd maintain that HIV's lethal action is much more subtle and indirect. Their model shows that CD4 cells actually self-destruct in the lymph system. Death comes as a result of exposure to biochemical signals involved in the homing process, which trigger apoptosis or cell suicide. "Previous HIV models ...Effect of exercise on reducing major depression appears to be long-lasting
... new $3 million NIH grant to better understand the subtle factors that may explain the positive effects of exercise in a new trial that begins enrolling patients this month. "We found that there was an inverse relationship between exercise and the risk of relapsing the more one exercised, the less likely o...Researchers discover major diabetes susceptibility gene
...eptibility. Understanding the mechanism of these subtle genetic tendencies should eventually provide targets for new medications, suggests Bell. Until then, the genetics of diabetes risk should help physicians discover which healthy young adults are most susceptible and begin to intervene. "As with all......es showed that each of the growth factors elicited subtle differences in effect. While none of the growth factors unequivocally directed development of differentiation toward a specific cell lineage, the studies hint that a combination and timing of growth factors might achieve such an end. Melton emphasiz...