Tag: "subtypes" at biology news

Probing the role of the delta opioid receptor in alcohol consumption

...he specific roles that each of the opiate receptor subtypes might play in alcohol addiction. Naltrexone has a greater tendency to interact with mu than with delta and kappa opiate receptors. It is possible that its success in alcoholism treatment is associated with its relative affinities for these receptor...

Gene chips bring new order to lung cancer types, could yield sharper diagnoses, better drugs

...s, said Golub. However, we also found evidence for subtypes [of adenocarcinomas] that are currently not recognized routinely, he said. So far, they are only identified as C1, C2, C3 and C4. Each type is characterized by different groups of genes that are very active or markedly inactive. And biologically, the...

Stanford researchers make lung cancer finging that could vastly improve treatment and outcome

...e distinct genetic subtypes. Patients within those subtypes had different outcomes, so knowing a subtype can g... the end of the study. Garber said that tumors in subtypes 1 and 3 were initially diagnosed with different stages of the disease. Those in subtype 3 all had mo...

Tracking path of virulent bacteria via the web

...ain characteristics and visual images of molecular subtypes (DNA fingerprints). The tool thus allows researchers quickly to assemble strain subtype data from different laboratories in order to analyze outbreaks and epidemics of many different infectious diseases and to assess the biodiversity of bacteria in ...

Genetic fingerprinting improves diagnosis and treatment of sarcoma

...to distinguish the moleculardifferences among many subtypes of adult soft-tissuesarcoma, a type of cancer that is often difficult todiagnose and treat. Using a sophisticated technology calledoligonucleotide array analysis, researchers developed agenetic fingerprint of each sarcoma, which will ultimatelyimpro...

Genetic markers key to identifying schizophrenic patients who can benefit from clozapine

...(CYP) isoenzymes. Currently more than 30 distinct subtypes have been identified (enzymes CYP1A2, CYP3A4, CYP2D6 and CYP2C19 of particular importance). Drug enzyme interaction: The metabolic relationship between antipsychotic medications Haloperidol, Ziprasidone, Risperidone, Olanzapine, Quetiapine, Sertin...

New findings change understanding of adult stem cells

...ertain ways. They lose the ability to make certain subtypes of cells that are made only during fetal development. And in the PNS, serotonergic neurons and noradrenergic neurons are only made during fetal development, suggesting that NCSCs undergo changes perinatally that are analogous to those in blood-formin...

JCI table of contents: October 1, 2002

...e the airways. The PDE4 subfamily is composed of 4 subtypes that are present in overlapping but distinct tissues of the body, and the hope is that it might be possible to develop subtype-specific inhibitors that are effective in the airways but do not interfere with PDE4 activity in other tissues. As a step ...

Not all mammals vomit -- or how to study emesis in mice

...e the airways. The PDE4 subfamily is composed of 4 subtypes that are present in overlapping but distinct tissues of the body, and the hope is that it might be possible to develop subtype-specific inhibitors that are effective in the airways but do not interfere with PDE4 activity in other tissues. As a step ...

Dr. Francis White, FUHS/CMS, receives MERIT Award

...ms, (3) identifying the roles of dopamine receptor subtypes in specific functions mediated by the dopamine systems, and (4) exploring the mechanisms of dopamine receptor interactions and how they regulate neuronal activity under normal and abnormal conditions. The study of dopamine systems in terms of cocain...

Families with two or more children with autism sought for $10.2 million study

...y kind of spoken language. There may well be many subtypes of autism, just as it appears there are different types of Alzheimer's disease. "In our genetics research we are trying to locate between five and 20 genes that are possibly related to autism. We are expanding our genetics studies because our earli...

New technique reveals drug resistance in breast cancer tumors

...ew technique called gene expression profiling that subtypes each breast cancer tumor by its genetic defects so that doctors can tailor their treatment to inhibit that particular tumor. The researchers believe the technique could spare millions of women from needlessly receiving toxic chemotherapy, and they ar...

A gene for sleepwalking

...=3.5, 95% CI=1.4_8.7). The family data for all HLA subtypes were further assessed for allelic association with SW using the transmission_disequilibrium test. A significant excess transmission was observed for DQB1_05 and _04 alleles in familial cases, strongly suggesting that a DQB1 polymorphic amino acid mig...

Why does caffeine delay exercise-induced fatigue?

... antagonist, and it is not known which of the four subtypes of adenosine receptors may be involved in an effect of caffeine on fatigue. However, A2b and A3 receptors are relatively less active than A1 and A2a receptors under normal physiological conditions. If the researchers were correct, the CNS administra...

St. Jude researchers use DNA chips to determine how leukemia cells respond to different drugs

...re differs significantly among the various genetic subtypes of ALL. These differences make it possible to differentiate among the major subtypes of leukemic cells. The differentiation also helps researcher to identify some patients at high risk ...

Early diagnosis of Usher syndrome type 1 made possible by new findings

...c dual deficit disorder. There are three clinical subtypes of Usher syndrome, the most severe of which is Usher type 1 (USH1). This syndrome involves deafness at birth, progressive blindness and balance problems. In 1861, a physician working in Berlin described the clinical features of Usher syndrome in Je...

KEPPRA international Phase IV SKATE study results show favourable efficacy

...iod. KEPPRA was also effective in the different subtypes of partial seizure. In simple partial seizures 36.6% of patients (90/246) experienced a reduction in seizures greater or equal to 50% and 17.9% were seizure free from this specific subtype. While 49.8% of patients (286/574) with complex partial seizu...

Human genes can predict AIDS progression rate

...tend to maximize and increase the frequency of HLA subtypes to provide better immunity against a range of pathogens. Nevertheless, pathogens evolve over time and develop the ability to disguise themselves and hide from HLAs. The study indicates that the AIDS virus has developed mechanisms to evade the most co...

Genetics pioneer from the Bronx wins Gruber Prize

... independent studies, to distinguish four distinct subtypes of breast cancer. Each subtype affects different c... shows a different life history. And each of these subtypes needs different medical treatment. "The subtypes match the genes. People with a particular genetic p...

Gene helps determine whether the stresses of life push you into depression, Science study says

... behaviors." Their body of research suggests that subtypes of genes can confer susceptibility to depression and possibly other serious diseases, according to Kelner. The participants in this study are part of the larger Dunedin Multidisciplinary Health and Development Study, which follows children born betwe...

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