Lycopene slows human prostate tumour growth in mice and combined with vitamin E is even better
... Rotterdam, said: "We found that low dose lycopene suppressed the growth of the human prostate tumours by over half (at day 42 of the study), extending the tumour doubling time accordingly, while all other single treatments had no significant effect. However, the combination of low-dose lycopene and vitamin E p...Certain genes boost fish oils' protection against breast cancer
...aboratory studies have shown that cancer growth is suppressed by n-3 fatty acid byproducts, and the suppression is enhanced by drugs that increase lipid peroxidation. When antioxidants are introduce to battle the effects of peroxidation, though, the cancer continues to grow. "Our findings may have practical imp...Molecular staples shape a cancer killer
...a cells. "We found that SAHB treatment effectively suppressed leukemia in these mice," he said. According to Walensky, the experiments are the first steps in a broader effort to construct hydrocarbon-stapled alpha-helical peptides that affect many control points of apoptosis. These are necessary because differ...Protective gene may enhance vaccine responses
... produced in higher amounts in memory T cells. It suppressed cathepsin B, a potent digestive enzyme that can induce cell death. T cell populations in which Spi2A levels were reduced produced fewer memory cells. As a consequence, mice with low Spi2A levels produced a severely diminished response to the virus ......obesity: Cpefat/fat mice, which are obese due to a suppressed metabolism, and Lepob/ob mice, which are obese due to overeating. Amazingly, this gene modification was able to dramatically decrease weight gain in both strains of mice, illustrating that C/EBP gene replacement can overcome both hereditary and dieta...OHSU researchers discover possible method for early detection, prevention of premature birth
...ination of drugs, intra-amniotic infections can be suppressed and premature birth prevented. In conducting this current research, the scientists used mass spectrometry analysis of non-human primates amniotic fluid to not only identify the protein biomarkers for intra-amniotic infections, but also the len...European researchers tackle mitosis
...ary of these molecules. About 20,000 genes will be suppressed one-by-one and EMBL researchers will make movies of the cells undergoing division, using sophisticated microscopes developed by Rainer Pepperkok, Jan Ellenberg and Leica Microsystems. Several hundred thousand movies will be produced, filming each gro...In the obese, metabolic adaptations post-weight loss lead to regaining of shed pounds
...rcent reduction in EE and 18 percent in SMR, and a suppressed NPRQ. Both EE and SMR declined to a greater extent than was expected from the combination of loss of body mass and reduction in energy intake, suggesting an increase in metabolic efficiency. NPRQ remained lower after the adjustment of energy balance ...Protein believed to control formation of memory identified by Scripps & UCSD scientists
...hey found that when the functions of normal CBP is suppressed in adult rodents, the animals had trouble forming long-term memories, suggesting that CBP is required for the formation of long-term memory and that defects in CBP are involved in cognitive dysfunction. Furthermore, the scientists found that they we...A new way to kill cancer: SLU research shows viruses can destroy lung, colon tumors
...jection of either INGN 007 or INGN 009 into tumors suppressed tumor growth more efficiently than a negative cont...sion, respectively). INGN 007 also completely suppressed tumor growth in a lung cancer model of disease. Louis Zumstein, Ph.D., director of research at I...Other highlights in the May 5 JNCI
...w South Wales in Sydney, Australia, and colleagues suppressed expression of c-Jun in microvascular endothelial cells (the cells that line blood vessels) by transfecting them with a DNA enzyme (DNAzyme) targeting c-Jun mRNA, and studied the properties of the transfected cells in vitro and in rodent models of t...Experimental smallpox DNA vaccine protects primates from lethal monkeypox
...rries a high risk of complications for people with suppressed immunity and other conditions. A DNA vaccine would not have the adverse side effects commonly associated with a live virus vaccine. "This work represents important progress toward a smallpox vaccine that is as effective as the current product, but s...Guiding gas exploration: U-M research offers inexpensive tool
...freshwater penetrated into these basin margins, it suppressed the salinity and created an environment that was conducive to methanogenesis within organic-rich black shales." In the current work, the research team compared the chemistry of water from wells drilled in the deeper center of the basin with tha...New approach offers potential drug-discovery shortcut
...ation. Two similar molecules were identified that suppressed the mutation, allowing the embryos to develop normally. The one that appeared more powerful, called GS4012, was chosen for further study. The gridlock-suppressing effects of GS4012 were found to vary with dosage, and no vascular abnormalities were ...New tumor suppressor may play important role in deadly brain tumors
...on of blood vessel growth. Implants of cells with suppressed ING4 expression grew much faster and developed more complex blood vessel networks than did the controls. The implants that overexpressed ING4 grew much more slowly and showed significantly less blood vessel growth. Further examination with an advanc...A new Twist on bone development
...lls that build bone tissue, called osteoblasts, is suppressed by a complicated inhibitory signal and that formation of the skeleton proceeds only after relief of the inhibition. This inhibitory signal is part of normal development, and without it, bone formation proceeds prematurely and abnormally. A gene call...UT Southwestern research halts narcolepsy symptoms
...at the orexin injections increased wakefulness and suppressed cataplectic arrests. Also, there was no "rebound sleep" after the orexin effect wore off. "This is extremely important because it shows that these mice retain the ability to respond to orexin," Dr. Yanagisawa said. "The downstream pathways, includin...Children's Memorial, TGen announce partnership
...entists to examine the genes that are expressed or suppressed in cells and compare the differences between normal cells and those that contribute to disease. TGen provides Children's Memorial's researchers access to a range of genomic, genetic and proteomic technologies, bioinformatics, high-throughput sequenci...Experimental smallpox vaccine protects against monkeypox in nonhuman primates
...high risk of adverse complications for people with suppressed immune systems. Smallpox, a devastating disease caused by the Variola virus, was eradicated in 1979 through the efforts of the World Health Organization (WHO). Currently, infectious Variola (a species of the genus Orthopoxvirus) is known to exist o......ent. In addition, the formation of scar tissue was suppressed in these animals. Although further long-term studies are necessary to clarify the effects of modifying phospholamban on arrhythmias, gene transfer of S16EPLN shows promise as a novel therapeutic strategy....