Tag: "suppressor" at biology news

Drosophila genome sequence completed

...g-sought Drosophila homologue of the p53 tumor suppressor gene, which is implicated in a host of human cancers. The biggest surprise to come out of the Drosophila sequencing project, says Rubin, is that flies have only twice as many genes as yeast. "Yeast is a simple, single-cell fungus, " says Rubin, "...

The genetics of aging: New study says cell division errors may be the common link

...domain), an essential binding partner of the tumor suppressor BRCA-1; hFRP-1, an analogue of the mutated AT (Ataxia-Telangiecstatia) that is linked to progressive neurodegenerative disease and premature aging; -crystallin, a heat shock protein that is overexpressed in neurological disorders such as Alzheimer's...

Hopkins scientists link human papillomavirus (HPV) to head and neck cancer

...7, which, in turn, inactivate the p53 and Rb tumor suppressor genes. They are planning a clinical trial of a cancer vaccine used for HPV-associated cervical cancers in these HPV-positive head and neck cancers. The vaccine would be given prior to standard therapy with surgery and/or radiation therapy. "Altho...

Scientists identify gene that causes fatal lung disease

...ne and one of the researchers. "TGFb is a growth suppressor gene so this gene, BMPR2, normally prevents the ce...from growing. When it mutates or is defective, the suppressor is stopped and it allows the cells to grow unregulated and they ultimately block the blood vessels. ...

Gene found to contribute to deadly form of breast cancer

... explains Merajver. The underexpression of a tumor suppressor gene called LIBC, also found by the U-M team in the prior study, may be one. Already, the team is continuing its study of all the factors....

UCSF-led study offers insight into cancer development, resistance to therapy: finding focuses on Ras oncogene

...d play an important role in inactivating the tumor suppressor during the early stages of some tumor development. This may be particularly true in colon cancers," says Ries. The p53 tumor-suppressor gene is one of several genes that serve as a protector of a cell's DNA. If DNA has been damaged, as can occur duri...

Science and Amersham Pharmacia Biotech grand prize: "jumping DNA" discovery explains immune system evolution

...ukemia by activating oncogenes, inactivating tumor suppressor genes, or creating chromosomal translations." Research has not yet demonstrated jumping-DNA transposition in living cells, Agrawal emphasized. But, she added: "It's somewhat logical that errors in V(D)J recombination could have undesirable results, a...

Team identifies first drug therapy for rare, precancerous stomach illness

...ase in children led to the identification of tumor suppressor genes and the "two-hit hypothesis" - the idea that it requires the functional loss of both copies of such a gene to prompt cancer development. "From rare diseases, we often gain important insight into more common diseases," he said. Mntrier...

New clue to diagnosis and treatment of malignant melanoma

...s are characterized by mutations in the p53 tumor suppressor gene. Malignant melanomas, however, do not typical...principle mechanism whereby Apaf-1 and other tumor suppressor genes can be inactivated, resulting in cancer when other copies of such genes are lost, mutated, or ...

Epstein-Barr virus linked to invasive breast cancer and lymphoma

...at the EBNA-3C protein binds to a human metastatic suppressor protein called Nm23-H1, which is found in all human cells. "The interaction between the two proteins disables Nm23-H1's natural ability to keep malignant cells in their original location thereby promoting metastasis," explains Robertson. "We have ...

UNC to test virus treatment for recurrent head and neck cancer

... is E1B. This gene's protein inactivates the tumor suppressor gene, p53, which normally protects the cell from adenovirus infection. "Unless p53 is inactivated, adenoviruses cannot replicate," explained Wendell G. Yarbrough, MD, assistant professor of otolaryngology/head and neck surgery at UNC-CH. "About 50% o...

Scientists find new supressor gene involved in breast, prostate and other cancers

...t the University of Texas have found a novel tumor suppressor gene on human chromosome 7 that appears to be involved in a wide range of cancers. Tumor suppressor genes play a key role in the regulation of cell growth. Scientists have known for about 15 years tha...

Mice nibbling at the secrets of NF1

...NF1 patients have defects in the NF1 gene, a tumor suppressor that negatively regulates the Ras protein. Ras acts as an intermediate between growth factor receptors on the outside of cells and the enzymatic cascade inside that activates genes required for cell proliferation and growth. NF1 is an essential check...

Introgen publishes preclinical findings demonstrating the potent anti-tumor properties of INGN 241 study featured on the cover of Molecular Medicine

...nal studies indicate that the mda-7 gene has tumor suppressor activity in some of the most prevalent human cancers. Introgens research also demonstrates that the MDA-7 protein is secreted. These unique properties of INGN 241 suggest that it may be a potent anti-tumor agent for local-regional applications, and...

Common genetic mutation linked to uterine cancer

...y lesions, linked to alterations in the PTEN tumor suppressor gene, are detectable even in normal-appearing tissues, suggesting there may be a way to predict future risk of endometrial cancer even when no pre-cancers are visible. Apparently they arise naturally in a small number of endometrial cells during norm...

UT Southwestern researchers show tumor-suppressor genes linked to insulin signaling

... genetic link between the tuberous sclerosis (TSC) suppressor genes and insulin signaling. Tuberous sclerosis affects 1 in 6,000 individuals and is caused by a mutation in either the TSC1 or TSC2 tumor-suppressor genes. The disease is characterized by the widespread development of benign tumors (tubers) that h...

Study reveals molecular key to tumor suppressor activity

...explains for the first time how an important tumor suppressor gene, p53, is activated in response to DNA damage to keep cancer tumors in check. About half of all human cancers are defective in p53 function. Thus, the new findings may have implications for the development of drugs aimed at boosting p53 activity...

All RBs are not alike: insight into RB in the plant cell cycle

...sely studied protein, owing to its role as a tumor suppressor in humans. RB-like proteins exist in plants, and their function has been base on the mechanism of action in animal cells. Published in Genes& Development, this work provides an alternative model of RB action. In mammalian cells, RB is a key checkpoin...

Genetic mutation may be key to onset of deadly skin cancer

...y gene known as Id1 deactivates an important tumor suppressor gene (p16/Ink4a), allowing cancer cells to grow uncontrollably.* High levels of Id1 proteins are found only in the first stages of melanoma, allowing it to be detected and treated while still in a curable stage.trigger skin cancers and could serve a...

New protein may play role in preventing malignant change in cells

...e for production of Fbw7) is very probably a tumor suppressor gene, Elledge said. Genes are associated with the production of specific proteins. Tumor suppressor genes and their associated proteins work to prevent cellular changes that can cause tumors. When som...

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