Critical Therapeutics launches Phase I clinical trial of anti-inflammatory compound
...sponses activated after exposure to endotoxin as a surrogate marker to identify promising agents with potential as anti-inflammatory drugs."...Surrogate mothers have no doubts about handing over the baby
... to anecdotal reports in the media, none of the 34 surrogate mothers interviewed for the study reported any mis...irth appeared to lessen with time. The majority of surrogate mothers enjoyed good relations with their commissioning couples and did not suffer adverse reactions...$13 million grant boosts breast cancer research
...t cancers respond to this type of drugs as well as surrogate markers predictive of EGF receptor inactivation in situ. (Arteaga and Dr. Mark Kelley). Predictive markers of clinical response to paclitaxel therapy in Stage II/III breast cancer. This project will test of the hypothesis evidence of tumor cell a...Alcohol's pharmacological properties, not smell or taste, reinforce its effects
...he predictor of alcohol's effects, in this case, a surrogate nipple. Previous research has indicated that infants, but not adults, might find the taste of alcohol reinforcing. Infants readily consume even high concentrations, up to at least 30 percent alcohol, whereas adults are reluctant to consume concentr...Enzyme fully degrades mad cow disease prion
...ite dangerous to work with, researchers will use a surrogate protein produced from yeast that has similar physical and chemical properties, but is non-pathogenic. Shih hit upon the idea of using keratinase to degrade prions based on his more than two decades of work as a poultry scientist looking for ways to m...Predicting progression of common cancers
...ngiogenesis--Chang et al. used this signature as a surrogate marker to measure how much tumors may be like wounds. When they compared the wound-like genetic signature with the expression profiles of various clinical tumor samples, they found the signature was always present in certain cancers--prostate and liv...New advance to combat antibiotic-resistant pneumonia and malaria
... million lives worldwide. Using baker's yeast as a surrogate disease model, researchers led by Dartmouth Medical School are exploring why enzymes in organisms that cause pneumonia and malaria are becoming increasingly resistant to antibiotics. This work could provide the answer to testing a new generation of ...Pacifying bacteria prevents lethal post-op infections
... high molecular weight polymer however, can form a surrogate bioshield, much like the intestine's own mucus, and stop this whole process before it begins, essentially putting the bacteria at ease. It prevents the chemical signals of stress from reaching the bacteria and triggering the virulent response. It ...Advances in equine cloning may aid insight into human diseases
...ning efforts. The authors implanted 305 oocytes in surrogate mares. Each of the three mule clones resulted from embryos exposed to higher calcium concentrations. Consequently, the successful birth and development of these foals offered new opportunities to explore an alternate method of calcium regulation in ...Mice cloned from olfactory cells
...been removed. When these eggs were introduced into surrogate mother mice, the resulting offspring proved viable and fertile. Furthermore, they exhibited the normal pattern of odorant-receptor gene expression and organization of odorant receptor genes. According to Axel, the cloning achievement eliminates one p...Insights on stroke from the peripheral blood suggest ways to develop markers and therapies
...'s response to stroke may allow the development of surrogate biomarkers of stroke risk and prognosis and give information on new cellular and pathological mechanisms involved in the etiology and response to acute stroke, ultimately leading to new drug therapies or preventive vaccines. Blood studies are infinit...Tips from the Journals of the American Society for Microbiology
...tudy, coliphage MS-2, considered to be a practical surrogate for pathogenic viruses, was exposed to silver individually and then combined with UV radiation. Results showed that when exposed to only silver for ten minutes little inactivation occurred, but ten minute exposure time to silver followed by UV radia...Protein engineered to detect nerve gas
...bed how they had designed a protein that detects a surrogate for soman, called pinacolyl methyl phosphonic acid... chose PMPA because it is a commercially available surrogate of soman and is a breakdown product of the nerve agent," said Hellinga. "The design technique we use...Other highlights in the July 7 JNCI
... as measures of molecular drug effects in tumor or surrogate tissue or functional imaging studies, were not routinely incorporated into the study design and rarely formed the primary basis for dose selection. The authors conclude that although phase I studies of targeted anticancer agents in general continue ...Children's Hospital Boston receives more than $10 million to help make smallpox vaccine safer
...b tests three weeks later. Varicella will act as a surrogate for vaccinia, yielding clues about how atopic dermatitis may alter the immune response to live virus vaccines. Understanding the relationship between atopic dermatitis and EV is important because atopic dermatitis is so common, with the highest prev...Congress to fund Sequim-based coastal security research effort
...loping novel ultra-small nanomaterials to serve as surrogate collectors and sensors. These "smart" sensors are designed to selectively capture and preconcentrate signatures in the marine environment. "The vision is to establish a network of sensors and biosensors that can be easily and inexpensivelydeployed ac...Chernobyl study: Risk of thyroid cancer rises with radiation dose
...c proximity to the northern Ukraine plant or other surrogate measures of exposure, this study is the first of its kind to factor into the equation individualized estimates of radiation dose based on in-person interviews about diet and other lifestyle factors, said Davis, a member of Fred Hutchinson's Public He...Diabodies act as guided missiles targeted to mammary tumor growth
...h. The research shows that a diabody, an antibody surrogate just one third the size of native antibodies, can be used effectively as a targeting vehicle for radioimmunotherapy, said Gregory Adams, Ph.D., associate member of the Medical Science Division, Fox Chase Cancer Center, Philadelphia, Pa. Diabodies ...Lycopene slows human prostate tumour growth in mice and combined with vitamin E is even better
...groups. This means that we can use PSA values as a surrogate marker in short phase II/III human trials as it is clear that PSA values are accurately reflecting the inhibiting activity of the lycopene and vitamin E on tumour growth. "What was particularly marked was that it was the low dose of both lycopene and...