Highlights of the October 2003 Journal of the American Dietetic Association
..., a change in bone architecture and an increase in susceptibility to fractures. A study led by researchers at the University of Utah found that low levels of physical activity are related to femoral neck bone mineral density among not only women and their daughters, but their granddaughters as well. The researchers...Cancer prevention pioneer receives AACR/Cancer Research and Prevention Foundation Award
...nvision a future in which we can screen people for susceptibility to certain cancers with a simple blood test and prevent those cancers from ever gaining a foothold through chemoprevention, lifestyle changes, and other measures. That day is not as far off as many people think." Dr. Hong said. Dr. Hong is the head ...JCI Table of Contents, 1 October, 2003
...eeth, and sweat glands in addition to an increased susceptibility to infection. In an accompanying commentary, Jordan Orange and Raif Geha from Harvard Medical School discuss how the study of human gene mutations that result in dysreguation of the NF-kappaB pathway has provided insight into the functions of individ...Project to make smallpox inoculations safe by 'leashing' current vaccine virus
... to the virus that will give it a hidden weakness: susceptibility to a common, widely tolerated antibiotic or anti-viral drug. The modifications will not change the virus's effectiveness in immunizing against smallpox, but will give doctors a sure and effective way to treat it in rare cases where it causes serious ...Hormonal changes in satisfied and dissatisfied shift workers across a shift cycle
...limited knowledge of the mechanisms behind disease susceptibility in shift workers. A new study contributes to the growing body of knowledge. Background Studies have shown that sleep in shift workers is often displaced and/or shortened, particularly in connection with morning and night shifts. Several laboratory...JCI Table of Contents, September 15, 2003
...pens avenues for identifying genes involved in the susceptibility to renal disease. TITLE: JunD protects against chronic kidney disease by regulating paracrine mitogens AUTHOR CONTACT: Fabiola Terzi INSERM U426, Paris, France. Phone: 33-1-44-85-62-70 Fax: 33-1-42-28-15-64E-mail: terzi@bichat.inserm.fr View the PD...Some forms of cancer behave in an unexpected way
...ulation, or those related to another breast cancer susceptibility gene, known as BRCA2. These results are surprising, because previous studies have indicated that BRCA1-related breast cancers tend to behave aggressively. Thus, the preferred route of spread of BRCA1-related breast cancers may be different from othe...U of MN researchers find genetic variations may predict treatment responses for myeloma
...lethal in others. By determining a patient's toxic susceptibility to drugs through analysis of specific genetic variances, or single nucleotide polymorhphisms (SNPs), in genes known to promote myeloma growth, clinicians can adjust dosage levels or choose alternate, safer drugs to benefit the patient. Led by Brian...Tips from the Journals of the American Society for Microbiology
...or three months. Cultures were then extracted and susceptibility to four biocides and six antibiotics were analyzed...of triclosan exposure did not affect antimicrobial susceptibility in environmental communities. "Long-term exposure of domestic-drain biofilms to sublethal levels ...New blood test uncovers individual risk for lung cancer
...vered a new genetic risk factor that increases the susceptibility of smokers to lung cancer. Published in the Journ...aim Sheba Medical Center to determine whether this susceptibility is caused by a decreased ability to repair DNA damage. Our DNA is damaged about 20,000 times a day ...Northwestern's Cancer Genetics Program pinpoints gene that increases cancer risk by 26 percent
...eight people is the most commonly inherited cancer susceptibility gene identified so far, increasing cancer risk in ... put TGFBR1*6A on the map with better known cancer susceptibility genes such as BRCA1 and BRCA2 that have been implicated in an estimated 5 to 10 percent of all breas...JCI Table of Contents, 15 August 2003
...f the anti-MOG immune response as well as the high susceptibility of most animal strains to EAE induced by MOG. Therefore, immunotherapy aimed at inducing tolerance to MOG might be beneficial in the treatment of MS. TITLE: Myelin/oligodendrocyte glycoproteindeficient (MOG-deficient) mice reveal lack of immune tole...Modifier gene controls severity of neurological disease in mice
...'t cause disease by itself, but produces a genetic susceptibility to mutations in other genes," Buchner explains. Mice with two copies of the B6 variant of the modifier gene had just 5 percent of the normal amount of functional Scn8a protein and died soon after birth. "The mutation in Scnm1 reduces the amount of S...Hopkins is first US institution to obtain powerful genotyping system
...investigating the biological basis of individuals' susceptibility to disease." The Illumina system's BeadArray technology uses dimpled fiberoptic strands in bundles no thicker than a pencil lead, each holding tens of thousands of tiny beads. Each bead is labeled with one of up to 1,300 DNA tags to unmask the versio...Common nutrients fed to pregnant mice altered their offspring's coat color
...er, these four supplements lowered the offspring's susceptibility to obesity, diabetes and cancer. Results of the st...that maternal nutrition profoundly impacts disease susceptibility in their offspring, but we never understood the cause-and-effect link," said Randy Jirtle, Ph.D., pr...A molecular genetic mechanism for schizophrenia
...eloping rat brain, dysfunction of DISC1 may confer susceptibility to psychiatric illnesses through abnormal development of the nervous system....University of Pittsburgh study links gynecological complaint to increased risk for herpes
...irst author. "The presence of BV seems to increase susceptibility to herpes infection in women." Worldwide, herpes s...e screening and appropriate treatment could reduce susceptibility to HSV-2," said Dr. Hillier. Unlike HSV-2, which typically has a life-long duration of infection, BV...Gene helps determine whether the stresses of life push you into depression, Science study says
...esearch suggests that subtypes of genes can confer susceptibility to depression and possibly other serious diseases, according to Kelner. The participants in this study are part of the larger Dunedin Multidisciplinary Health and Development Study, which follows children born between April 1972 and March 1973 in Dun...A sex-specific gene for depression
... human genome as the potential hiding place for a susceptibility gene for depression in women. "These findings con...m our earlier research suggesting the existence of susceptibility genes that have sex-limited effects on the vulnerability of women to developing severe depression," ...Cyclacel's biomarker technology shows that CYC202 induces cancer cells to commit suicide
...duce cancer cells to commit suicide) and determine susceptibility or resistance to the treatment. In the long-term biomarker analysis of tumour blood and tissues may allow selective treatment with CYC202 of those patients identified as likely to benefit from the drug based on the specific genetic profile of their t...