Researchers find mechanism that may determine early blood cell fate
...r, GATA-1 levels must be lowered if HSCs are to be sustained in an undifferentiated state. "We reasoned that there was a reciprocal, opposing relationship between GATA-1 and GATA-2," Bresnick said. By observing the way the proteins interact with sequences of genes in living cells, Bresnick and his colleagues ...Not for women only: Osteoporosis in men
... for bone density. So, too, should any man who has sustained a fracture in his adult life since the presence of a fracture is a very potent risk factor. After such a diagnosis is made, the first step in treatment is to remove any contributory factors, such as kidney stones, underlying factors such as alcohol, ...Hydrothermal vent systems could have persisted millions of years, incubated life
...ht improve the chances for life to spark and to be sustained until it could take hold, say these scientists. "It's difficult to know if life might have started as a result of one or both kinds of venting," says Deborah Kelley, University of Washington oceanographer, "but chances are good that these systems we...Endostatin promising treatments for AIDS-related cancer
...atin have shown promise," she said. "A controlled, sustained and local release of endostatin might be a good ap...radable polymer particles to provide a controlled, sustained release of endostatin over the span of several months. "Endostatin is a good drug, but the problem i...Chlamydia infection prevalent among female army recruits
...ic pregnancy and infertility," says Gaydos. "These sustained high rates of chlamydia infection in female Army recruits provide clear justification for a chlamydia control program for young women entering the Army, consisting of initial screening and treatment followed by periodic rescreening," says Gaydos. "Pr...Infants more vulnerable to serious brain injury from falling than previously thought
...lp distinguish between accidental falls and injury sustained by intentionally striking a child's head against a hard surface, although more research is needed before such results could make a clear difference in abuse investigations. "Traumatic brain injury is the most common cause of death in childhood, and ...OHSU researchers publish final results of groundbreaking smallpox vaccination study
... boost in immunity but, over time, do not create a sustained higher level of protection compared to those persons vaccinated only once." To conduct the research, OHSU enlisted the help of 332 study participants. Of this larger group, 306 participants had received at least one vaccination within their lifetime,...Francis Collins and Ari Patrinos receive Energy Secretary's Gold Award for Human Genome Project
...These awards are in recognition of your vision and sustained leadership of the international human genome project, which culminated in the completion of the human DNA sequence in April 2003," Secretary Abraham said. "The project's success was largely due to your ability to join the efforts of two agencies: th...Controlling the internal clock in darkness
...e to cycle as well within other clock cells. These sustained expression patterns, however, require intercellular communication between different groups of brain clock cells. In other words, the ventral lateral neurons do not act alone. When the molecular clock machinery was manipulated so that only the ventral...Zadaxin in triple therapy shows 61% response for hepatitis C non-responders
...VR in approximately 15-21% of non-responders and a sustained viral response (SVR) in only approximately 10% of ...patient's EVR is considered necessary to achieve a sustained response, but evidence shows that a patient who demonstrates an EVR may or may not achieve a SVR, an...Duke researchers link nitric oxide, vessel health
... disease." Allen then sought to discover whether a sustained program of exercise had any effect on nitric oxide production and reactivity of the brachial artery. So, he followed seven of the participants in the "at-risk" group during six months of exercise carried out on cycle ergometers, treadmills or ellipti...Mount Sinai School of Medicine conducting clinical trials with gene therapy for colorectal cancer
... it can not reproduce itself and can not lead to a sustained infection in patients. In animal experiments we have found that this maximizes both efficacy and safety and we hope to see the same in humans." The first organ to which colon cancer spreads is the liver and prognosis for patients with liver metastase...Inherent mistrust of research institutions limits minority representation
...Insights Research Analyst David Kramer. A patient, sustained outreach from research institutions to the minority communities is necessary to attract significant numbers to participate in clinical research. Developing a customized outreach plan and enlisting the aid of community leaders and social service agenc...JCI table of contents, February 2, 2004
...tes lose their clinical effectiveness when used as sustained therapy a phenomenon known as nitrate tolerance. ...Sinai Hospital, Canada, comments "the concept that sustained nitrate therapy causes increased production of free radicals has a number of important implications....Carbon dioxide fertilization is neither boon nor bust
... Norby notes, while his colleagues have observed a sustained increase in leaf photosynthesis, the response to carbon dioxide fertilization would not be apparent if only above-ground growth were measured. Wood production increased significantly during only the first year of treatment. While Norby and colleagues...Study predicts conditions for sustainable lion trophy hunting
...age five and older, populations of any size can be sustained without bag limits. The study, which also describes a means of estimating lion ages in the field, will be published online Sunday, Feb. 22, in the journal Nature. All African hunting reserves impose bag limits, or quotas, but quotas are supposed to b...New study seeks to establish mechanism between areas of the brain and continence
...s consisting of alternating 10-second intervals of sustained contraction and rest. In stage 2 studies, seven subjects (4 males) performed only maximum-effort sphincter contractions without a catheter. EAS contraction was associated with multifocal fMRI activity in sensory/motor, anterior cingulate, prefrontal,...Mix of chemicals plus stress damages brain, liver in animals and likely in humans
...e to occur to the entire brain. Brain regions that sustained significant damage in this study were the cerebral cortex (motor and sensory function), the hippocampus (learning and memory) and the cerebellum (gait and coordination of movements). Abou Donia's earlier studies demonstrated severe damage to the cing...Bioprocesses upstage traditional chemical processes
...ng more than 50 percent of revenues in R&D." These sustained efforts are paying off as more than 155 biotechnology drugs and vaccines have recently been approved by the Food and Drug Administration (FDA) in the United States alone. Remarkably, 75 percent of the approvals have come in the last six years. "The m...Astrazeneca announces EU marketing approval for Faslodex(TM)
...ke many other endocrine therapies, 'Faslodex' is a sustained release formulation that is administered once monthly as an intramuscular injection. As such, 'Faslodex' brings welcome compliance benefits for some women, and for the first time offers a monthly alternative to the once-daily tablet....