New Cancer Switch Discovered By Duke Medical Center Pharmacologists
...tein plugs into an adaptor protein called GRB-2 to switch on a chain of other enzymes that eventually activates the cancer gene, or oncogene, called ras, which launches uncontrolled growth. In the Proceedings paper, Gishizky, Cortez and Pendergast reported discovering that a purposely "damaged" form of GRB-...Honeybees In The Wild Nearly Gone In North America
...d other challengesoccur. We can't just whimsically switch to different bees andhave that solve all the problems."...Florida Researchers Discover Gene For Fatal Childhood Disease
...ukemia. The gene normally acts as a master switch to regulate the transport ofproteins within cells, said Dr. Stephen Kingsmore, a molecular geneticist atthe Center for Mammalian Genetics at UF's College of Medicine. InChediak-Higashi syndrome, the gene functions abnormally and many proteins failto ...Nitric Oxide May Hold Key To First Treatment For Deadly Form Of Malaria, Duke Scientists Report
..., a process now understood to be the primaryon-off switch for thousands of proteins that control life proces...offer SNOa target, which turns out to be a genetic switch that leads to its own destruction."he said. "The moment SNO enters a bacterium, a race is on as to w...Nitric Oxide Found To Control Cells By Turning On Genes; Suggests New Role In Health And Disease
..., a process now understood to be the primaryon-off switch for thousands of proteins that control life proces...offer SNOa target, which turns out to be a genetic switch that leads to its own destruction."he said. "The moment SNO enters a bacterium, a race is on as to w...Study Shows Songbirds Switch From Bugs To Berries To Fuel Fall Migration
...that many songbirdsmigrating south each autumn may switch from typical meals of insects to aberry-rich diet ...ation in The Condor, Parrish found that a dietary switch from insects to fruit occurred to somedegree in the majority of the 69 species sampled. Several spec...Cholesterol Anchor Helps Signaling Proteins Direct Development
...s. "While I do not suggest that expectant mothers switch to a high-fat diet, based exclusively on these results, it might be interesting to take a look clinically at the effect of a mother's diet on the developing fetus," says Philip Beachy, Ph.D., an associate professor of molecular biology and genetics a...A Sensor, A Switch, A Zipper: Protein Engineers Design Potential Tool
...xins or--in a laboratory setting--act as a switch to activate genes or as a molecular zipper to join together proteins. The newly designed structure is featured in the cover article of the June 1996 issue of Nature Structural Biology . "This desi...Scientists Determine 3-D Crystal Structure Of Cancer-Causing Protein
...inoacids that make proteins, acting as a molecular switch that turns proteins offand on. In this study, Kuriyan and co-workers Frank Sicheri, Ph.D., and IsmailMoarefi, Ph.D., determined the three-dimensional structure of Hck, one memberof the Src family of very closely related tyrosine kinases, name...Biosensor Is A Model For Widespread Testing Of Chemicals, Molecules
...nce of maltose,a sugar compound, in blood, and can switch on a molecule that produces fluorescentlight to signal its catch. With further modifications, the researchers believean array of biosensors can be created to instantly sample a wide varietyof "target" molecules, from hormones in blood to pollutants i...Scientists Trace Roots Of Protein That Keeps Antarctic Fish From Freezing
...isen out of strong selective pressureand an abrupt switch in environmental conditions adaptive molecularevolution. Demonstrations of this sort at the molecular level are rare andnoteworthy." Evolution of the antifreeze gene in the Antarctic fishes had a greatimpact on the ecology of the thermally iso......n a food trip for about two weeks. Then the couple switch nest-sitting duties every other day until the eggs hatch. For the first 30 days of the chicks' life, each parent will be gone for no more than 36 hours at a time, returning with digested fish which is regurgitated for the offspring. But then, as the ...Subtle Biotic Changes Have Big Environmental Impact
...sh populations in a lake, scientists have found a switch by which the flow of carbon between lakes and the atmosphere can be turned on, off, or reversed. The finding, reported by researchers from UW-Madison in this week's (July 11) edition of the journal Science, is the first to show that only slight r...Scientists Bridge Gap In Cell Communication
... family of proteins that carry genetic signals and switch genes on and off -- and their roles in communicating at a distance has implications for the development of new strategies to treat diseases caused by malfunctioning genes or disrupted pathways of communication. Communication -- or miscommuni...Newly Discovered Human Protein Provides Important Target For Cancer Therapy
...on and, at a more fundamental level, how all cells switch telomerase offand on." Ideal Target for Chemotherapy The telomerase enzyme is a complex structure containing multipleproteins and an RNA molecule (RNA is a chemical cousin of DNA and, in this case,acts as a template for the production of ne...Discovery Of Genetic Pathways May Provide New Ways To Combat Candida Infections
...to Candida's infectiousness lies in its ability to switch from a rounded form to filamentous forms. When the wiring diagram underlying this switch is inactivated, Candida infections are no longer deadly in mice. The implications of these results f...Low Oxygen, Key To Fetal Development, Also Offers Cancer Clues
Oxygen levels act as a switch controlling placentaldevelopment, scientists show in a paper published in theSeptember 12 issue of the journal Science . The study, ledby Professor Susan Fisher of the University of California at SanFrancisco (UCSF), is the first to show that low ox...Researcher Discovers Plant Genes For Phosphate Uptake
...othama says, phosphorus starvation flips a genetic switch that changes certain molecules in roots and makes plants better at acquiring phosphate. In collaboration with Jose Pardo from Instituto de Recursos Naturales y Agrobiologia in Spain, Raghothama decided to concentrate on plants' genetic and molecular ...Dendritic Cell Therapy For The Treatment Of Cancer
Dendritic cells help the body to switch on an immune response by seeking outforeign protei...re dendritic cells will pick up tumourantigens and switch on an immune response. One problem that Dr Austyn foresees is that patients with advanced cancer oft...... in Philadelphia have uncovered a new molecular switch by which mismatch repair is triggered. The work...otides. The scientists found that the molecular switch is “off” when a molecule of ATP--adenine triphosphate--is attached to the complex. W...