Tag: "switched" at biology news
Vitamin D may be crucial in preventing colon cancer
...vitamin D receptor. When the vitamin D receptor is switched
on, it triggers other proteins that detoxify the b... so they could detect whether the CYP3A gene was switched
on when LCA attached to the vitamin D receptor. Other investigators had published data showing that ...
Scientists identify the 'Bin Laden' of cancer causing faulty proteins
...ve cancer therapies. c-Myc is a protein which when switched
on grows more cells when the body needs them. Sometimes it fails to switch off or switches itself on when it is not wanted. Normally our bodies have a fail safe mechanism which causes cells to commit suicide if c-Myc malfunctions in this way. This sw...
Lake mud holds secrets to forecasting future salmon abundances, Queen's researchers say
...nd other foods; and when the salmon returned, they switched
back again. The research team believes their technique for studying fish populations is very powerful, and will be used increasingly to compare "natural" areas with those that have experienced specific interventions such as dams and controlled runs. ...
'Vigilant vector' could insert genes that sense, prevent heart attacks
... to experience hypoxia, or oxygen deprivation, and switched
on the protective genes, which prevented the damage and scarring, called ischemia, that usually results. It may take years, but UF researchers say the technique of using such vigilant vectors to transmit gene switches could be translated into treatme...
Candidate genes found which may play a role in cancer progressing from non-invasive to invasive
...olved in making cells stick together, appear to be switched
off in invasive tumours compared to non-invasive tumours. It is reasonable to assume from this that defects in these genes might make cells less sticky, which is probably necessary to becoming invasive. There are probably many defects involving pro...
SFVAMC study explains prostate cancer resistance to hormone therapy
...rogen receptors where the drugs act. The genes are switched
off by a process called hypermethylation, a well-k...hat reverses methylation, and the cells once again switched
on their estrogen receptor genes. People are testing de-methylating agents in clinical trials for ...
Proliferation of Argentine ants in California linked to decline in coastal horned lizards
...y cases, decline in weight. But when their diet is switched
to insects typical of an uninvaded community, the scientists found that the baby horned lizards grow normally. "A comparison of diets among age classes of coastal horned lizards suggests a diversity of ants is necessary to support lizard populati...
MCG researcher develops animal model for studying autoimmune disease
...-based weapons that rely on the whole system being switched
on. In that situation, we would like to be able to switch it off again," he said. In type 1 diabetes, pancreatic islet cells undergo similar attack, resulting in insulin deprivation and a myriad of related problems. "We don't know what kicks (the im...
New technique speeds gene research in mammalian cells
...etermining what happens to cells when that gene is switched
off. In addition, by switching genes off at random, researchers can select those cells that display interesting new properties, such as improved response to cancer treatment. The latter, unbiased approach is an attractive way to identify genes that a...
Clamping down on a cancer-causing protein
... of cell division and thus cancer. Abl needs to be switched
off, and one of the chief questions that people have had is whether other molecules are needed to throw the switch, or whether Abl can turn itself off, says Giulio Superti-Furga. Weve now discovered that there is an internal switch that allows it to ...
Protein may be target for new cancer drugs
...(EGFR) and Torso tyrosine kinase receptor remained switched
on constantly in the mutant flies, because they depend on Hrs for inactivation. When they analyzed the Hrs protein, the scientists determined that it could bind specifically to a chemical tag that targets receptors to the lysosome for degradation. A ...
Keep young and beautiful
...ng genes on and off. Min found that 100 genes were switched
on in response to PBA, including the one for super... for its anti-ageing effects. About 50 others were switched
off. Min's team are investigating these genes, and how PBA has its effect on the histone deacetylase...
Prizes awarded in the 2002 Gottfried Wilhelm Leibniz Programme
...knock-out mice, animals in which certain genes are switched
off to examine their significance for the organism, Birchmeier-Kohler and her research team have made a crucial contribution to the understanding of a number of growth factors and their role in the development of organisms. The processes observed in ...
Scientists milk animals for malaria vaccine
...um. The researchers designed the transgenes to be switched
on by the cells that line the mammary glands, such that the resulting proteins would be secreted into the animals milk. Both mouse strains produced large quantities of the desired vaccine protein, which was used to vaccinate monkeys against malaria...
Protein may play role in sex chromosome inactivation
... regulator of imprinted genes that are selectively switched
off during development. CTCF sites are known to exist in a number of other genes, in human and mouse genomes, said Lee. And when we simply asked whether the conserved regions we discovered matched those CTCF binding sites, we found that they did. In ...
Switching on the fly genome
...g RNA molecules, which are produced when genes are switched
on, they can potentially monitor the entire genome...riments. In one type, the JNK information route is switched
off, and the signals dont reach the genes. In the other, JNK is overactive, sending a signal of abno...
UC Berkeley expert on insect flight receives prestigious MacArthur 'genius' award
...sue sculpture when he entered Brown University, he switched
to neurobiology because of his fascination with the mechanisms that underlie animal behavior. His honors include a graduate fellowship from the National Science Foundation (1985), the Larry Sandler Award from the Genetic Society of America (1990), a ...
Researchers reveal new clues about spread of colon cancer
...in the metastatic cells, indicating that they were switched
on during metastasis. Although all the genes were ...s are tumor suppressor genes, whose activities are switched
off during tumor formation. The proteins encoded by these genes are not good targets for potential d...
DNA transcription is tuned to specific cells
...o used DNA microarrays to explore which genes were switched
off in knockout mice that lacked a functional copy of the TAFII105 gene. The TAFII105 protein is one of a family of TAF proteins that are subunits of a large complex called the transcription factor TFIID. "When TFIID and all its associated factors we...
Fire ant queens and workers negotiate truce' on colony sex ratio
...ly male or mostly female offspring. The scientists switched
queens from about a dozen female-producing colonies with queens from about a dozen male-specialist colonies. Originally female-specializing colonies almost immediately began producing mostly males, while the originally male-specialist colonies produc...
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