Tag: "synchrotron" at biology news

NIH, Argonne sign agreement

...the scientific community by facilitating access to synchrotron beamlines for protein crystallography. This is par...ed, Dr. Cassman said. NCI is interested in how the synchrotron facilities will advance the study of cancer at the molecular level. "Given recent advances in our u...

New x-ray technique images cartilage, may lead to earlier diagnosis of osteoarthritis

... degeneration earlier. The DEI images taken used synchrotron radiation from the National Synchotron Light Sourc...e looking at alternative energy sources that mimic synchrotron radiation. Fortunately, DEI isnt reliant on the high energy of synchotron radiation, but on the ali...

X-ray analysis of shipwreck may help conservators save waterlogged artifacts

...ay absorption spectroscopy. It employs high-energy synchrotron beams, produced when electrons accelerate around rings, to make chemical "fingerprints" that identify different oxidation states in a sample. Their findings, published in the Feb. 21 issue of Nature, may help conservators worldwide preserve wooden ar...

NIH funds synchrotron beamlines to advance studies of molecular structures

... a major threat to its continued growth is limited synchrotron resources. Synchrotrons are the enormous machine...hese few days to make the best use of their scarce synchrotron "beam time." To advance structural studies of biological molecules, the National Institute of Genera...

Researchers at Vanderbilt's Free-Electron Laser Center are developing new forms of laser surgery, improved X-ray technology, and better methods for protein identification

...or this kind of radiation have been billion dollar synchrotron radiation laboratories associated with large particle accelerators. A private company with Vanderbilt support has developed a prototype monochromatic X-ray machine that it estimates should cost about $1 million to produce commercially. The FEL is ...

Molecular structure could advance understanding of human disorders

...-rays produced by the Advanced Photon Source (APS) synchrotron at Argonne National Laboratory in Illinois. The results suggest that the complex is formed in a series of steps. The metallochaperone begins as two copies of CCS bound together (known as a homodimer because of the like parts). Similarly, the target ...

Experimental microbeam radiation therapy may offer improvement over traditional radiation treatments

...in clinical radiation therapy, only high-intensity synchrotron sources can be used to confine the beam to the extremely narrow slices with very high dose rates that are needed for MRT. In the current study, the scientists used a single exposure to irradiate the entire brains of duck embryos three to four days be...

X-ray crystallography at Advanced Photon Source

...use of devices called undulators. APS is the only synchrotron in the United States that can regularly use these ...aid that one of the most important applications of synchrotron radiation that will be pursued at Argonne is multiple wavelength anomalous diffraction, known as MAD...

Digging for genetic fossils: Hutchinson Center researchers solve structure of ancient biological molecule

...diffraction studies using an Advanced Light Source synchrotron at the Lawrence Berkeley National Laboratory. The ... speed of light, for structural-biology studies. A synchrotron provides a more intense diffraction pattern than standard X-ray crystallography, providing much high...

Translating the human genome into protein function: structural genomics research at Columbia

...cilities. Says Dr. Hendrickson: "This all requires synchrotron beams. MAD phasing can only be done at a synchrotron source. We've developed a facility with Howard Hughes Medical Institute funding at Brookhaven Nation...

Major new initiative to resolve structure of protein families

...Advanced Light Source (ALS).The ALS is an electron synchrotron that produces beams of x-rays and ultraviolet ligh...tter of weeks, days, or even hours. "The use of a synchrotron radiation source such as the ALS can dramatically decrease the time required to solve novel protein ...

Argonne leads new Midwest Center for Structural Genomics

...al Biology Center at the Advanced Photon Source, a synchrotron facility that provides the country's most brillian...ined more new protein structures than at any other synchrotron beam line. He predicts 200 protein structures will be solved next year. Such high-throughput facilit...

SGX signs agreement to build state-of the-art beamlines at advanced photon source

...access to intense X-rays beams from the DOE-funded synchrotron radiation source. "Today's agreement is recogniti...recision. The Advanced Photon Source is a national synchrotron radiation research facility located at Argonne National Laboratory near Chicago, Illinois. It is cur...

Molecular structure key to allergies and asthma is identified

...-rays produced by the Advanced Photon Source (APS) synchrotron at Argonne National Laboratory in Illinois. "In order to design drugs effectively, a chemist needs to know the structure and shape of the target molecules," said Theodore S. Jardetzky, the Northwestern X-ray crystallographer who led the study. "Our...

Brookhaven Lab collaboration determines the atomic structure of a key enzyme called a 'biological blowtorch'

...other chemicals. The compound then was exposed to synchrotron x-rays, which added electrons to the mixture, causing a chemical reaction that is the hallmark of the enzyme: It splits molecular oxygen into two atoms and inserts one of the atoms into a hydrocarbon -- in this case, into camphor. While the resea...

Uncovering structure of cellular switch could aid design of cancer-fighting drugs

...plex was mapped at MacCHESS, Cornell's high-energy synchrotron source, where the scientific technique called X-ray crystallography reveals the three-dimensional arrangement of atoms in molecules by bombarding them with intense bursts of X-rays. A "ribbon" diagram of the Cdc42/GDI complex is printed on the cover...

Advanced light source reveals secrets of ribosome structure

...ught by transfer RNA. Until the advent of synchrotron radiation facilities like the ALS,obtaining detailed information about macromolecular structures such as ribosomeswas an almost insurmountable challenge. Yet this information is essential forunderstanding the mechanism by which these critical organel...

UCSC researchers obtain first detailed images of a complete ribosome

...tional Laboratory, one of a handful of siteswith a synchrotron capable of producing the high-energy x-rays needed forcrystallography of a structure as large as the ribosome. In the first and longer of the two papers, the researchers present the structureof the complete ribosome with several of the molecules invo...

Key Asthma And Allergy Molecule Pictured

...liant X-rays produced by theAdvanced Photon Source synchrotron at Argonne National Laboratory in Illinois. "We think this identifies the structure that all of the members of this antibodyreceptor family will have," says Theodore S. Jardetzky, the Northwestern X-raycrystallographer who led the study. As a class, ...

Tumor Protein Structure Found At Cornell

...ornell High Energy Synchrotron Source(CHESS). The synchrotron produces high-intensity, high-energy X-ray beams forscientific research. MacCHESS is supported by the National Institutes of Health for research in drugdesign, protein and virus crystallography and data collection from synchrotronsources. CHESS i...

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