Harvard Medical School researchers discover first in a new class of mitosis inhibitors
...s chemistry is so well known that the next step of synthesizing andtesting modified versions would be straightforward. Chemists at the ICCB aremaking such variants. Meanwhile, Mayer and Kapoor are using monastrol in ongoing studies ofexactly how Eg5 helps build and maintain the mitotic spindle. Mitchiso...UCSC researchers obtain first detailed images of a complete ribosome
...es responsible for translating the geneticcode and synthesizing proteins. They are the link between the geneticinstructions encoded in DNA and the protein molecules that carry out theactivities of living cells. The images obtained by the UCSC researchers show how different parts of theribosome interact with one a...Jefferson scientists further develop gene repair technique
...to repairgenes with a single mutation. It involved synthesizing a small molecule termed achimera, consisting of DNA interspersed with small amounts of RNA, that has thecapability to find and attach itself to a certain part of a gene. The smallgenetic vehicle is designed to trigger the cell's normal DNA repair sys...Researchers at UNC-CH succeed in synthesizing ginkgo molecule
...rolina at Chapel Hill have succeeded in completely synthesizing ginkgolide B,a complex molecule produced naturally...n W. King reporteddeveloping an improved method of synthesizing the desired form of variouscompounds - including those used to treat AIDS - that occurred in twomirr...Enzyme's Structure Yields Blueprint For Antibiotic Resistance
...ture is responsible for the final chemical step in synthesizing aneurotransmitter important in the control of mood, depression and anxiety. Inanother incarnation, a structurally similar enzyme acts as a switch that freesDNA to become active and begin expressing messenger RNA. Such widespreadbiological activity gi...Clever Chemistry Protects Beetle Babies
...onfirmed Schröder's structural assignments by synthesizing one of the mostimportant of the large-ring compounds. "One of the most exciting features of the beetle pupae's defensivechemicals is the sheer magnitude of the rings," Schroöder says. "Ordinary cyclicnatural products often have rings cons...Human Metabolite Of Taxol Synthesized In The Laboratory
... percent." Yuan will share the process for synthesizing 6a -hydroxypaclitaxel in aposter presented at the American Chemical Society's 215th national meeting inDallas, Texas March 29-April 2. The poster (Divsion of Medicine #178) will be inthe Dallas Convention Center, Exhibit Hall D/E , Level 3, on Wednes...Chemists Develop High-Throughput Method To Synthesize And Screen Novel Antibiotics
...ati researchers havedeveloped a system for quickly synthesizing and screeningpotential replacements for standard antibiotics, such aspenicillin and amoxicillin. All of these antibiotics fall intothe category known as beta lactams. Chemistry graduate student Jie Wang will explain a key part ofthe system Sunday, Se...Pea Plant Stem Growth Gene Cloned
...rate. Therefore, dwarf peas are less efficient at synthesizing the gibberellic acid responsible for promoting stem growth. The plant becomes growth deficient. Gregor Mendel (1822-1884), the father of genetics, conducted experiments on the hybridization of plants, particularly peas. The results of his research ...Method Eases Making Amino Acids Critical In Medicinal Chemistry
...ug can be significantly enhanced." In addition to synthesizing enantiomers of aryl amino acids, Beak alsohas used his chiral ligand chemistry to create a variety of enantioenrichedacids, amides, amines and aldehydes. Beak's latest research results werepublished in the March 21 issue of the Journal of Organic Che...A Sensor, A Switch, A Zipper: Protein Engineers Design Potential Tool
...e desired structure--a triple helix. After synthesizing this newly designed protein, the scientists used x-ray crystallography to determine its three-dimensional shape. The result confirmed, with a clarity unusual in the field, that they had successfully predicted the final...Duke Researchers Discover Central Role Of Nitric Oxide In Hemoglobin Action
...be comparable in importance. Here we havethe lungs synthesizing a compound and delivering it to tissue where it ismetabolized, just as oxygen is." In addition, the research shows that NO has a regulatory "allosteric"function that has not been described before, Stamler said. Allosteric regulationis when ...