Study: Microgravity May Enhance Gene Transfer In Plants
...the mobility of bacteria, Bula says, theyhit their target more easily. Gene transfer techniques are increasingly important to the agriculture industry,as it looks for faster and more selective alternatives to complement traditionalplant breeding. Bula says that this growing season, genetically engineeredvar...Researchers Discover A Common Protein's Deadly Role In Breast Cancer
...mof the insulin receptor now appears to be a clear target for drugs to block orslow breast tumor growth." The Molecular and Cellular Biology paper established that a shortened form ofthe insulin receptor, known as IR-A, is the fetal form, or growth-stimulatingform, and that it is activated by the growth-ind......e, the authors couldshow that Tbx4 is a downstream target of another hindlimb specific gene, Pitx1.These results published in Nature (29 April 1999) implicate these importantgenes in the determination of fore- and hindlimb identity in vertebrates. In this study Takeuchi et al used an important new approac......rivate sector. The spinal cord was selected as the target for the beta-endorphin gene, not onlybecause of its ease of access, but also because it is the first processing pointfor relaying pain signals to the brain, and pain can be effectively controlledat this location. The idea was to have beta-endorphin ...Plant-Based Fat Inhibits Growth Of Breast-Cancer Cell Line, UB Researchers Show
... of cancers, or we could eventually design drugsto target systems they influence," Awad noted. "Meanwhile, these findingsreinforce the importance of including large amounts of vegetables in the diet." In the current work, Awad's research team examined the effect ofB-sitosterol and another prevalent...Rockefeller University Scientists Receive Prestigious Awards For Cancer Research
...specific activators thatregulate their function on target genes. Dr. Roeder explained that over the years he has become increasingly interestedin the applications of his research. "We need not only to understand themechanisms underlying normal gene expression, but to relate these to importantmedical proble......tics andimmunology, and to develop treatments that target specific functions of theorganisms."...UT Southwestern Researchers Find Way To Control Gene Activity, Opening Way For Cancer Drugs
...fy a small molecule that can enter cells, bindto a target gene and turn the gene off," said Dr. David Corey, co-author of thestudy, associate professor of pharmacology and biochemistry and a Howard HughesMedical Institute (HHMI) investigator. "We have a simple way to get PNAs intocells, and we have determin...Researchers Discover How The Immune System Shuts Down Faulty T Cells
...ells also stopped making anenzyme needed to kill a target cell. The CD 8 cells, starved of class 1 contact, also began transcribingtheir genes for two surface proteins known to touch off a genetic cell deathprogram. Another two days later, the cells were dead. Cantor's team also discovered the gene...Slimy Bacteria Common Cause Of Chronic Infections
...concerted effort to develop therapeuticagents that target the biofilm phenotype and community signaling based agentsthat prevent the formation, or promote the detachment, of biofilms," the articleconcludes. The techniques are now available to undertake such efforts....Researchers Discover Fast Efficient, Controllable Way To Study Molecular Interactions
...se thiscross-linking technique to determine a drug target within a cell." The other researcher on this study was Dr. David Fancy, postdoctoralfellow in pharmacology and biochemistry. A National Institutes of Health grant funded the study....UCSF-Led Team Offers New Insight Into Neurological Basis Of Dyslexia
...y neurological deficit, they said, could provide a target forremedial therapies aimed at training the brain to increase the speed andaccuracy with which it processes rapidly successive and rapidly changing sounds. The sound-processing function occurs at a base, or entry, level of soundprocessing in the brai...Researchers Propose A Revolutionary New Theory About The Way Cells Communicate
...his criticalcommunication was initiated not by the target cells in need of instruction, butby the cells that...rphogens," act by directing gene activity in their target cells. Inrecent years, researchers have identified some of these signals, includinghedgehog secreted......ouslyestimated. While current gene-mapping efforts target the identification of 400,000 geneticmarkers to help locate common disease genes, many more such signposts must befound before the map can be considered a truly useful tool for pharmaceuticalresearch and development, says the paper's author, Dr. Leon...Report in Science on x-ray crystal structure of matrix Metalloproteinase-2 (MMP-2)
MMP-2 is a key target for anti-cancer drug development Research Triang...matrixmetalloproteinase-2 (MMP-2), a key molecular target for a number of anti-cancerdrug candidates currently in clinical development. This work was complet...New mechanism explains Alzheimer's damage
...ists[U1]think the discovery could provide a unique target for new drugs to treatAlzheimer's, which causes de...gs, such as aspirin and some antibiotics,similarly target metals on the active site of a specific protein. "If we couldmake drugs that specifically shut down......'pro-inflammatory cytokine,' LIF, and itspituitary target regulator, SOCS-3." The research team, which included Cedars-Sinai investigators Corinne Bousquetand Chris Auernhammer, M.D., was able to identify the regulatory structure ofSOCS-3, a molecule in the hypothalamus and pituitary, and show how it functi...The Foundation for Genetic Education and Counseling
...re professionals.Initial educational programs will target individuals affected by or at risk forcomplex diseases and will help develop genetic counseling services toindividuals who have participated in genetic research protocols. Day-to-day operation of the foundation will be the responsibility of Joseph D.......bility of testosterone to properly bind and signal target cellsto initiate the functions that they are programmed to carry out decreases. Among the 30 percent of the study population for which DDE levels weremeasurable, concentrations ranged from 0.1 to 0.63 nanograms per milliliter.This top value of 0.63 n...Brown University research team finds keys to liver development
...edicine."The liver is a critical organ and a target for viral hepatitis, alcoholism,metabolic diseases and cancer." The experiments were conducted using undifferentiated cells, calledendoderm cells, removed from the inner layer of mouse embryos. In the developing mouse, these ...