Gene Shears In Cutting Edge Anti-Aids Trial
...s virus as a "taxi" to insertthe ribozyme into the target CD4+ cells. The ribozyme acts by slicing upthe messenger RNA which instructs the HIV-infected cell how to make newinfectious HIV particles. The hammerhead ribozyme technology was originally patented by CSIRO in1987. Gene Shears Pty Limited was estab......chemistry. Once the EGS molecules attach to their target in aspecific virus or bacteria, they cause an RNA ...overies. Innovir is developing EGS molecules that target virusesthat cause hepatitis B, hepatitis C, psoriasis and other inflammatory diseases,as well as dru...Scientists Discover How Genes Work Together To Control Neural Development
...pod and Sina, and demonstrated thatthey team up to target the Tramtrack protein for destruction. In the process,they also discovered the first known biochemical function for the Phyllopodand Sina proteins. "Our test-tube experiments demonstrated that Sinaand Phyllopod bind to each other to form a partnershi...New Gene May Intensify Breast Cancer Growth
... growthresponse pathways. It could eventually be a target for therapeutics. It willcertainly be a target for significant additional biologic studies to understandits action," said Dr. Paul Meltzer, the sen......s is a breakthrough because it offers a novel drug target fortuberculosis," Belisle said. "Based on this finding, we can create new drugsthat inhibit the enzymatic reactions responsible for keeping the cell wallintact, which will result in the death of the TB bacteria." Colorado State's Mycobacteria...Newly Discovered Human Protein Provides Important Target For Cancer Therapy
...ion of human tumor cells provides an important new target foranti-cancer drug design. Researchers led by Dr... "The telomerase enzyme is an ideal target for chemotherapy because thisenzyme is active in about 90 percent of human tumors, but inactive in m...Trojan Horse Virus Controls Hiv Infection
...5 and CCR3 in an attempt toaffect HIV strains that target macrophages and typicallypredominate in early HIV ...vo delivery of a vector that can find its destined target in the body. Thereshould be no need for ex-vivo manipulation of cells." She envisions manypotentia...Low Oxygen, Key To Fetal Development, Also Offers Cancer Clues
...argetumor, because radiation and anti-cancer drugs target cells thatare dividing. Scientists like Ludlow someday hope to break downthis protective hypoxic barrier and make these cells morevulnerable to treatment. Ludlow's work is sponsored by the National Institutes ofHealth (NIH) and the Sally Edelman...Mutant Gene Not Sole Explanation For Hiv Non-Progression
... the CD4 molecule, to enter certain of its target cells. HIV-infected people with a specific mutation in one of their two copies of the gene for this receptor generally have a slower disease course than people with two normal copies of the ...Wonder Thread: UD Scientists Report First Protein With Collagen And Elastin-Like Domains
...reign molecules by binding with them--helped Coyne target preCol-P. First, messenger RNA (ribonucleic acid) containing the genetic code for the protein was extracted from mussel foot tissue. Next, RNA was converted to the more stable DNA (deoxyribonucleic acid) form and cloned into bacteria, which expressed......randy. "Consequently, the D4 receptor may be a new target for the treatment of drugabuse." Grandy explains that humans show a wide variability in the gene thatencodesthe D4 receptor, and there are reports that some forms of the D4 gene maypredispose an individual to drug taking and novelty seeking behaviors...Further Proof That An Altered Rb-2/p130 Gene Leads To Lung Cancer
...gies to combat lung cancer, including finding a target for [future efforts in] gene therapy. "In order to have some therapeutic value, a test needs to be developed that is cheap and accessible to everyone," he explained. "We would like to run prospective studies as well to be able to antici...Scientists Identify A Novel Mitotic Regulatory Mechanism
...traordinary dependent on phosphorylation of the target sequences. This consensus binding specificity has ...some novel isomerase targets. Surprisingly, the target sequences are overlapping with antigens recognized by a known mitosis-specific monoclonal anti...Pitt Researchers Construct Novel Delivery System For Gene Therapy Of Liver Disorders
...d quickly delivering them to theirdestinations, or target cells. A research team from the Universi...y effective intransferring their cargo of genes to target cells. "The role of RCRs is to transport substances in the body. Because theyexcel at thi...New Molecular Switch Is The Key That Unlocks DNA Repair
...potential to enable researchers to specifically target anticancer drugs to these genes. Accordi... function, we are provided with a foundation to target the process as a whole.” Dr. Fishel and his colleagues report their results in the ...3-D Structure Of HIV Components May Pave The Way For New Anti-AIDS Drugs
...s intonew viral particles. The protein is a prime target for anti-AIDS drugs, becauseprevious studies have shown that when it is crippled, HIV cannot spread to othercells. New drugs that block the action of the RNA component could be equallyimportant. The detailed structure of the protein-RNA complex, det......per. "In addition toproviding information on a key target for therapeutic intervention, thestructural data we have unveiled also suggests a possible mechanism of nucleicacid unwinding for this and related helicases. " "The solution of the HCV helicase structure complements the solution of thethree-dimensi...'Rolling Circles' Provide New Way to Amplify and Detect DNA
... way to produce ultra-bright fluorescent labels to target individual DNA sequences in the body's cells, Kool says. He is also investigating a new kind of gene therapy, whererolling circles inserted into cells might produce RNAs thattarget cancer-related genes and viruses like HIV. Kool's work is fund...Technique Gives Researchers New Look At Genetic Activity In Living Cells
... interaction in which a proteinbinds to a specific target in DNA without altering chromosomal structure. The traditional DNA hybridization technique for localizing a particularchromosome region cannot be done on living cells, and it causes some damage,a problem that has seriously limited structural and mech......se. "The virus has developed an insidious means to target different cells in thebody to promote its growth at the expense of its host," Nabel says. "Thesestudies provide greater understanding of its molecular control and approacheswhich might protect against infection."...