Research Uncovers A Key To Aging And Lifespan Determination
...l beingdeveloped that will allow us to selectively target cells in the nervous systemsof mice or humans." In addition to developing the necessary tools, the next steps in this field ofresearch will include identifying other types of cells that are equallyimportant in the aging process. Researchers will als......ces and spread to the nervous system. It is aprime target for novel prophylactic or therapeutic interventions," Spear said. Ongoing research in Spear's laboratory is directed toward identifyingcell surface proteins that can mediate entry of herpes simplex virus intovarious cell types, including nerv...Molecular "Fossils" Of Early Life
...e tailor-made to break down only in thepresence of target molecules, making them effective as biosensors for detectingtoxic chemicals in the environment or for medical diagnostics. Working incollaboration with a Jerusalem-based firm called IntelliGene Ltd., Breaker plansto create biosensors for detecting b...Newly Recognized Cell-Surface Receptor Protects Heart Tissue Against Damage
...es of Health (NIH) have identified a new molecular target that couldlead to novel and improved therapies for...idney Diseases. "Now we have shown that a specific target molecule on the cell-- the A3 adenosine receptor -- protects the heart muscle lacking oxygen andnutr...New Gene Therapy Technique Results In Efficient Gene Delivery
...dge. The new technique links the virus and target cells by a bridgeconsisting of two proteins?the growth factor EGF and the receptor for a proteinfound on the avian leukosis virus (ALV). When applied to cultured cells, theprotein bridge allowed the virus not only to bind but also enter the designate...Penn Researchers Invent World's First Device To Rapidly Assess Lung Function
... topinpoint the severity of the pulmonary disease, target correcttherapy, and assess status of the patients' conditions. MIGET is an established research tool for studyingmechanisms of impaired pulmonary function. With MIGET, traceamounts of six inert gases are dissolved in saline and infusedintrav...Crystal Structure Of Key HIV Protein Reveals New Treatment Targets
...Infectious Diseases (NIAID). "We now havespecific target sites on which to focus in developing new drugs an...nd thereforevulnerable, it could be another useful target for drugs or vaccines. A large "silent face" - a surface that does not react to antibodies and ist......d news is that silent synapses provide a potential target forpain blockers. As opioids and other drugs target normal pain pathways, othertreatments might target these secondary pain pathways, interrupting the p...Virginia Tech Biologists' Discoveries Could Help Target Cancer Treatment
...either DNA synthesis or repair, RPA is a potential target fortherapeutic intervention. "Using deletion analysis and site-directed mutagenesis we haveidentified promoter elements that regulate the glycogen phosphorylase geneduring cell differentiation of Dictyostelium," Rutherford reports. ...Gene Variant Found That Can Help Protect Against Nicotine Addiction
...this enzyme plays in nicotine addiction gives anew target for developing more effective medications to help people stopsmoking." Researchers found three different gene types (alleles) for the enzymeCYP2A6, including a normal, or wild-type allele that is fully functional, andtwo null or inactive all...Discovery Of Plant-Like Metabolic Pathway In Common Parasites Supplies New Targets For Therapy
..., could also become drug targets. Medications that target the shikimate pathway may also prove valuable againstother disease-causing bacteria or fungi that rely on the pathway, such as Mycobacterium tuberculosis , which causes tuberculosis, Staphylococcusaureus , a common and increasingly drug-resistant ca...A Synthetic Peptide Destroys Brain Plaque Implicated in Alzheimer's Disease
...n directly causes Alzheimer's disease, itis a good target for therapy," says Dr. Soto. "We think that these findings openthe way for a new therapeutic approach to treating Alzheimer's disease bypreventing the deposition of senile plaques," says Dr. Soto. "We also believethat our compound may be useful in tr......where seminal virus is produced, we may be able to target treatments tothis site and suppress replication of viral strains which may be different thanthe ones found circulating throughout the body. This is absolutely crucial to stemmingtransmission of the virus." Previous research has provided evid...Scientists Learn How Cells Limit Their Stress
...s defective inaged cells, this molecule could be a target for drug development," he said. Other researchers on the paper are Sanjeev H. Satyal, Dayue Chen, Susan G. Foxand James M. Kramer of Northwestern Medical School. The research was funded by the National Institutes of Health....UNC-CH Researchers Develop Promising Heart Research Tool
...es. You also may be able to design drugs that will target cells in theborder zone." The National Heart, Lung and Blood Institute, the Office of NavalResearch, the UNC Board of Governors and the N.C. affiliate of the AmericanHeart Association supported the research. By David Williamson Note: ...NASA Research Helps Map Protein Structures -- Key In The Development Of New Disease-Fighting Drugs
...AIDS therapies. Neuraminidase is a target for the treatment and prevention ofthe flu. Influenza protein crystals from several Space Shuttle flights had asignificant impact on the progress for a flu medicine. As a result, several potent inhibitors of viral influenza (types A and B) have bee...UF Discovery Of Chicken Gene Mutation Aids Study Of Rare Inherited Eye Disease
...edfor the work they do, which enables us to better target them for genetherapy." LCA-I is among the earliest and most severe forms of autosomalrecessive inherited retinal degeneration. Autosomal recessive diseasesoccur when a person receives a defective copy of a particular gene fromboth parents. ...New Alzheimer's-Associated Mutation May Provide Key To Disease Process
...ue of Nature Genetics. "It could be a powerful new target for the developmentof drugs to prevent or treat this disease." Tanzi and his colleagues stressthat the new mutation is not appropriate for use in diagnosing or predictingAlzheimer's disease. The data also are being presented July 22 in Amsterdam att......ok place at the most minuscule level - the team's target was a molecule which is only ten billionths of a ...e solution. The big difference is that the team's target crystal has over 7,000 atoms, whereas salt has just two. The crystals were then bombarded with X......edical Center, Dallas/Texas, identified a novel target of the diacylglycerol second messenger pathway ...olite of membrane phospholipids. The "textbook" target of the diacylglycerol second messenger pathway is protein kinase C. This kinase enhances trans...