Dismantling Dangerous Genetic Codes With A Faster, More Flexible RNA Mimic
... normal RNA. Speed is vital to destroy the harmful target right away. The method iscompatible with living cells and shows great promise for chemotherapy."Because of his status as the inventor of metal-based ribozyme mimics, Bashkinwas the invited editor of the May 1998 issue of Chemical Reviews, an issuede...Subtle Changes In Brain Receptor Gene May Have Significant Consequences For Addiction
...ing pre-clinical findings present a very important target foradditional research into what makes people vulnerable to addictive diseases,"says Alan I. Leshner, Ph.D., director of the National Institute on Drug Abuse(NIDA) of the National Institutes of Health, which funded part of the study. The scientists ......ogy."The study's findings identify a new molecular target upon which to aim theemerging arsenal of weapons in the battle against Alzheimer's disease," Mattsonsaid. Par-4 may play a critical role in nerve cell death in Alzheimer's disease andrelated brain disorders. Cell death is a fundamental problem in ag...New Evidence Shows How Some Flu Viruses Become Lethal
...he virus' surface that allow thevirus to attach to target cells. Normally, a viral surface protein called hemagglutinin must be chopped into two parts before the virus can infect a cell.The virus uses an enzyme from the cell it is invading to clip the protein. The enzyme that acts as a "scissors" is...Structure Of Enzyme Involved In Gentamicin Resistance Revealed For First Time
...inding slot bythe researchers, presents a possible target for drugs aimed at thwartingantibiotic resistance. "We think that this narrow cleft acts as the binding site for gentamicin andholds it in place," says Burley. "When the acetyl group is transferred to theprotein, the gentamicin flies off. These findi...Virus Linked To Causing Enlarged Hearts In Children With Certain Genetic Makeup
...ain genetic sequences that direct the virus to the target organ, in thiscase, the heart." Among the various viruses, some may have a genetic sequence, which turns regularantigens into "super" antigens, powerful enough to trigger a more aggressiveimmune response. In the children studied, a superantigen led ......riment, mice had to learn the location of a hidden target ina maze that tests their ability to remember and ...ay home. ApoE3 mice learned how to find the hidden target with relative ease, whereastheir apoE4 counterparts had difficulty with the exercise, and some never...Scientists Closer To Locating Gene That May Explain Cholesterol Absorption
...ne's cholesterol absorption, this genewould be the target of treatment," Patel said. "We hope this is the key genethat will allow us to target cholesterol absorption as a whole new form of drugtherapy." "Our studies of sitosterol...Gene Mutation Found For Common Form Of Mental Retardation
...ne approach to treating people with MRX would beto target kinases. "If the kinase is dead or partially functional, we might tryto boost the activity," says Walsh. Yet he cautions that they will need to knowmuch more about how PAK3 works before they tinker with kinases or anything else. This research...Gene Therapy Showing Promise In Fighting Melanoma
...nformation that benefits those projects. "Wetry to target a lot of the research we do so it will benefit the development anddesign of human clinical trials," he said. Dogs provide a good model for understanding cancer in humans, MacEwen said,because of their large size and biological similarity. The causes ......ly shows that we should consider designing drugsto target mitochondria to prevent or intervene in glutamate-...he surface ofmitochrondria may prove one important target for drug design, he added. As with all living cells, a neuron consists of a cell membraneen...Simple Chemical Switch Steers Migrating Neurons
...ld never wire properly. An axon's path towards a target neuron is steered by growth cones thatare located in the tip of the axon. These growth cones receive cuesabout the best path to follow from chemical attractants and repellentssecreted by cells in the central nervous system. Until recently, scientist...Combination Therapy For Brain Tumors Holds Promise For Longer Survival After Surgery
...f Mark I. Greene, MD, PhD,at Penn. Both strategies target mutated or overexpressed erbB receptorproteins tha...lls that remain after surgery. "ErbBs are anatural target to block," says O'Rourke. "There's more of a biologicallikelihood that we may impact this disease an...Hutch Researcher Wins 'Nobel Prize Of Applied Research'
...System cansuccessfully infect up to 100 percent of target cells. The system also is notedfor its ability to ...troviral vector to create particles that caninvade target cells and deliver the gene of interest. "Clontech was particularlyinterested in offering this packag...Cubist Pharmaceuticals Describes New VITA™ Technology For Enabling Genomics For Drug Discovery
...ate-limiting steps between protein identification, target validation and thediscovery of new drug leads. We... peptide inhibitor of an essential target. "Other target validation technologies, such as gene knock-out studies, antisenseinhibition of RNA and ribozyme tec...Antioxidant Treatment Holds Promise For Combating Malnourishment
...ry to design the defense soit goes directly to the target organs," Bray said. Bray and her colleagues fed rats a diet severelydeficient in protein (0.5 percent) for 14 days. The animals were thendivided into three groups for a four-day-long feedingperiod: one group continued on the protein-deficient di...Jefferson Scientists Suppress Tumor Growth In Animals, Aiming At Gene Therapy
...(programmed cell death). Gene therapy would target cancers in which we know this gene isinvolved--lung, mesothelioma, endometrial, breast, glioblastoma, lymphoma," hesays. "We are working on a delivery system for every cancer."...Plant-Based Fat Inhibits Cancer-Cell Growth By Enhancing Cells Signaling System, UB Researchers Show
...tate cancer, or we could eventuallydesign drugs to target this system," he said Phytosterols are used widely in Europe to treat enlarged prostate(benign prostatic hyperplasia), Awad said, and are known to lower the risk ofcardiovascular disease by interfering with cholesterol absorption. B-sitostero......TLs could be used to deliver cytokines to diseased target cells without thetoxicities observed when cytokines are administered systemically. Targeted Genetics has supported two Phase I studies of HIV-specific CTLs in HIVinfected patients conducted by Riddell and Greenberg at the Hutchinson Center. Additio...... biology techniques to pinpoint important parts of target genesand amplify them, and a new, high-accuracy gene sequencer/software system toreveal mutations. "The most definitive way to see if someone's a carrier is toanalyze the gene," says Cutting. Nearly 200 mutations have been identified inthe ALD gene,...