Cell Suicide Prevented By Survival Signals
... Cell ,Steller's team defines a precise molecular target that allows cells from thefruit fly Drosophila t...he mammalian version of Hid could be an attractive target for therapy ofneurodegenerative diseases, spinal cord injury or stroke. Researchershypothesize that ...UNC Researchers Reduce Arthritis Severity By Turning Off Molecular Switch
...indings underscore NF-kappa B as a very attractive target for arthritistreatments, including a new generation of drugs targeted specifically to themolecule," says the team's leader, Dr. Sergei S. Makarov, research assistantprofessor of medicine at the UNC-CH School of Medicine and the ThurstonArthritis Rese...EMAP II: A Cytokine Regulated By Apoptosis
...id residue, the EMAP II cleavage site resembles target sites of caspases, a family of proteases with a pivotal role in apoptosis, also known as programmed cell death. Little was known about the expression of EMAP II or the regulation of its cleavage. Scientists in W. Risau’s dep......he identification of gene function and therapeutic target validation. RPI isdeveloping an anti-angiogenesis... clinical trials. It has entered into therapeutic target validation anddiscovery collaborations with Schering AG (Germany), Chiron, Parke-Davis, RocheBioscie...Cardiac Clinical Trial Studies Use of Antibiotic In Preventing Heart Attack
...beenexcellent, and Dr. Cercek anticipates that the target number of 1,400 patientswill be reached within 12 to 18 months. Funding for this clinical trial issolely provided by the Division of Cardiology and the Stephen S. Cohen Fund. Formore information, please call 310-855-3836....New Forest Owners Prefer Enjoying Their Land Over Working It
...t shift their educational and extension programsto target these new landowners. "Now we have to learn how t...nagers statewide, Jacobson said, is to find waysto target the new type of landowners and educate them on the consequencesof not managing their forests. A sugg...New Company Formed Through Licensing Of Cardiac-Hypertrophy Technology From Texas Institutions
...hese are the first really good genetic models that target cardiac enzymesand appear to constitute the master switch in the process of cardiachypertrophy," said Dr. Stephen Grant, director of UNT Health Science Center's cardiac and vascular molecular geneticslaboratory. "We found that if this switch is left ...Scientists Finger A Molecular Kingpin In Body's Response To Cigarettes
...he body immune to chemicals in cigarette smokethat target the receptor. The team's compounds are very similar tomolecules known as "flavonoids" found in foods like broccoli,cabbage and soybeans, all known cancer fighters. "We all know people who smoked their whole lives but nevergot lung cancer," says ...Vitamin E Prevents Early Plaque Formation
...l. Preventing this step could be another important target in the treatment ofatherosclerosis, said Jialal, who is also a senior investigator in the Centerfor Human Nutrition at UT Southwestern. The laboratory study examined the effect that vitamin E had on themonocyte's ability to bind itself to endot...Swedenvironment No. 3 Highlights
...nic Production To Get Sustainable Agriculture The target level for organic production could be 5-10 % of the total production in Europe in the near future, according to a Nordic seminar on sustainable agriculture. Better Requirements For Micro-Organisms Before They Are Registered As Pesticides It is in...New Findings On Receptor Regulation May Lead To Better Drugs For Diabetes
...s distant site, Lazar says, provides an additional target forthe next generation of diabetes drugs to hit. If compounds can be found thataffect this regulatory site, they may lead to diabetes drugs with fewer sideeffects, according to Lazar. Specifically, the researchers discovered that although the...Tracking A Killer's Progression
...y the immuneresponse, but researchers believe Yops target phagocytic cells, the body's firstline of defense against invaders. The bacterial killing response of thephagocytic cells is paralyzed, and the cells are rendered incapable of sendingmessages to other cells to begin an immune response to the pathoge...Could A Nasal Vaccine Finally Get Rid Of The Black Death?
..., he adds, the vaccine should be in a formthat can target tissue lining the gut or respiratory system. That is what Oya Alpar and her colleagues at the University ofBirmingham have come up with. They took a protein from the surface of Y. pestisand combined it with another that is secreted by the bac...Genetically Engineered Mice Exhibit Anxiety, Offering Insight Into Role Of Serotonin In Brain
...ed by its success, or lackthereof, in reaching its target receptors, and the response that these receptorshave to the neurotransmitter--either stimulating or inhibiting its activity. While unusually elevated or inhibited serotonin activity has been implicated inmany psychiatric disorders, scientists are unc......ucture soscientists can design drug therapies that target a specific problem with few orno side effects. It's a bit like safe-cracking at the atomic level. Most of the protein crystal growth hardware requires little of the spacestation's resources and crew support. They only need to be turned on, and daysor......ween proteins on the surface of thevesicle and the target organelle leads the "train" to its station where i... a region with ahigh propensity to wrap around its target protein like a snake wrapping around alimb. Uncovering these structures is an important ste...Cellular Target Of Leprosy, Deadly Viruses Found
...uses a fatalform of muscular dystrophy is also the target that the leprosy bacterium uses tolatch onto cells before invading them. And in an equally surprising twist, italso appears that two hemorrhagic fever viruses gain entry to cells via the samemolecular handle. These discoveries could lead to new drug...... be highly efficient at introducing its genes into target cells. Theythen stripped the AAV of its own disease-causing -- and immune-system provoking-- genes and reloaded it with a normally occurring gene called insulin-likegrowth factor I, or IGF-I, as well as a muscle-specific promoter to drive highproduct...Possible Breast Carcinogen Found In Human Milk
...k implies that breast ductal epithelial cells, the target of mammarycarcinogens, are also exposed." AAs are used in the production of plastics, dyes, pesticides, andpharmaceuticals. Environmental sources for AAs include in industrial waste, air and waterpollution,tobacco smoke, and some foods. The study t...Wistar Scientists Gain Information About Molecular Recognition
...that might explain how it affectsactivation of its target genes." "These interactions," explains King, "are giving us important information aboutmolecular recognition. Once we understand how each protein recognizes aparticular DNA target, we will be able to develop proteins with unique DNArecognition...