Key Asthma And Allergy Molecule Pictured
...e pharmaceutical industry because it is a verygood target for therapy. But there is absolutely nothing commercially availableright now that hits that target. "With the solving of the structure, now we have the opportunity to deriveinformation which could help in the design of molecules which could inhibit I...New Discovery Offers Hope For Controlling Cholesterol, Atherosclerosis
...ating uptake of dietary lipids and offers a better target for drugs tocombat obesityand heart disease. The finding is detailed in both the web and Dec. 22 print editions of thepeer-reviewedjournal Biochemistry, published by the American Chemical Society, the world'slargestscientific society. The small int...Immortalizing Enzyme Does Not Make Human Cells Cancerous
...holar. "We believe that telomerase is an important target both for thepotential treatment of age-related disease and for cancer." Other UT Southwestern investigators involved in this research includedformer research fellow Dr. Shawn Holt; cell biology and neuroscience researchfellows Dr. Michel Ouellet......ted thedevelopment of Salmonella that specifically target tumors over normal tissues.However the clinical utility of such bacteria was potentially limited by theability of lipid A in the bacteria's cell walls to elicit the production ofTNF-alpha and trigger septic shock. Now the researchers have shown that ......this protein as a marker for inflammation and as a target for research to determine the role of infection and other factors such as high blood levels of cholesterol and cigarette smoking in the initiation and progression of cardiovascular disease. At the American Heart Association's Scientific Sessions in...Molecular Doorway Holds Key To Gene Therapy
...important implications for deciding which cells to target for humangene therapy using the virus. "We will only have a high probability of successfully delivering genesto patient cells if the cells carry virus receptors," Samulski says. "The integrin story tells us that binding is the first step, int...Hopkins Scientists' Sequencing Of AIDS Virus From India Waves A Red Flag For Vaccine Developers
...roteins in the outer"envelope" of the virus -- the target of most of the trial anti-viral vaccinesto date -- vary significantly from the subtype B strains that form the backboneof vaccines currently in international trials. "It means we could expectproblems with any vaccine based solely on envelope proteins...Serendipity: Cell Structure Study Uncovers Taxol's Secrets
...up,however, found that Taxol also attacks a second target in cancer cells -- onethat may make it easier for researchers to develop more efficient anti-cancerdrugs. In order to find which other parts of a cell Taxol could bind, theFlorida State researchers created a huge library of bacterial viruses,......bout alpha-1 that makes it a potentially difficult target forgene therapy is that very high serum levels are required to prevent thedevelopment of emphysema," said Dr. Terry Flotte, an associate professor ofpediatrics, molecular genetics and microbiology and co-director of the Gene Therapy Center at UF's Co......nimals have a blood systemto transport hormones to target sites around every part of the body, but plantsdon't. Instead, plants use a specialised delivery system to transport auxin fromcell to cell. This delivery system, called the polar auxin transporter, haseluded scientists for a long time, even though i...Fool An Egg Into Thinking It's Fertilised, And It Will Repel All Comers
...appens in humans, the integrin receptor could be a target for anew contraceptive that deceives the egg. "It would be great if you couldprematurely activate an egg," says Janice Evans of the Johns Hopkins School ofPublic Health in Baltimore, Maryland. But so far, researchers have failed toactivate mammalian ...Encouraging Results In Preclinical Studies Of Parkinson's Disease Gene Therapy
...eans by which therapeutic genes areintroduced into target cells or tissues to induce a therapeutic effect and are acritical component of any successful gene therapy. The AAV gene delivery systemis one of four vector systems under development at Cell Genesys. Cell Genesysholds a broad U.S. patent covering ......ns grow, often over quite long distances, into the target region thatthe corresponding nerve cell is supposed to hook up with (2). Once arrived inthe target area, an axon selects its target cell from a large number of possiblecandidates (3). Next, a synapse...Experimental Drug Derived From Snake Venom Shows Promise In Reversing Effects Of Stroke
...red promptly,within 6 hours, and maintained in the target range after treatment had the bestresponse to the treatment," says Sherman, professor and chief, division ofneurology, University of Texas Health Science Center, San Antonio. The initial amount of ANCROD administered is determined by the pati...Researchers Identify Molecular Site That Is Key To HIV's Ability To Infect Cells Of Brain, Colon
...mmunology at UC San Francisco, suggests a possible target for therapies aimedat preventing the virus's entry...re not. While these tissues are not the principle target of HIV infection, studies indicate that, when infected, cells in these tissues may be the underlying......ignificant one. If we can replicate thepattern and target therapy directly to the fracture site through injection,there is potential for greatly improving our ability to treat a bone healingproblem," Miclau said. This type of targeted, molecular-based treatment would be more desirable than abone graft, whic...UCSF Researchers Pinpoint Molecule That Triggers Deadly Progress Of Pulmonary Fibrosis
...ein's specific and localized role makes it a prime target for developinga drug to block the severe lung scar...wing the role of the integrin, we have a potential target to control TGFBeta activity if it goes awry," Sheppard added. "The mechanism we describedshows a way......ue. While CD4-negative cells are not the principle target of HIV infection, studiesindicate that these cells...co-receptor do not need to be displayedtogether on target cell surfaces to be engaged by HIV, and that they cancooperate as an effective viral receptor comple...... important. The gene, he said,could "make a great target for chemotherapy agents." As it turns out, RRM1 is...lock the enzyme,rendering it ineffective, or could target the remaining copy of the RRM1 gene toprevent it from producing the enzyme. As with all cancer treat......expected to act in a highly specific manner at the target site. Normally, GLP-2, a peptide hormone, acts in the body as a potent stimulator ofcell growth in the lining of the small bowel. This growth dramaticallyincreases the surface area of the intestine, where nutrients are extracted fromfood and then ci...