Wistar Scientists Define Mechanism Of Action Used By Potential Magic Bullet In Cancer Treatment
...oxicchemotherapeutic drugs that have an ability to target mutated oncogenes whilebypassing normal cells; i.e...esign other types of nontoxic antitumor drugs that target the sameprinciple....The Body's Anticancer Weaponry Backfires In Old Age
...leviate some effects ofold age. He says drugs that target caspases may help preserve the ageing immunesystem. "If we can delay the cell-death process, we may improve not just lifespan but the quality of life in old age."...Researchers Find How Two Cancer Genes Interact To Cause Malignancy
...heway to developing therapeutics that specifically target the abnormal function,leaving the normal functions alone," he said. Other authors of the Molecular Cell study were Rosalie Sears and Gustavo Leoneof Duke, and James DiGregori, formerly of Duke and now at the University ofColorado at Denver....Antiviral From Advanced Viral Research Corp. Inhibits CCR5 Cell Receptor For HIV
...ors needed by the AIDS virus, HIV, to attachto its target cells and initiate infection. Interference with the function of the CCR5 cellular chemokine receptor is knownto increase the resistance of T-lymphocytes and macrophages to HIV infection. Amutation in the CCR5 gene, especially prevalent in individual......plores theterritory it traverses on its way to its target tissue. The twain now meet in two NIH-fun...ve b (ISNb) arrested its growth beforereaching its target muscles, suggesting the disrupted genes were essential forthe growth cones to proceed. In mutants du...... in either sex. The survival, axonal outgrowth and target innervation of sensory neurons dependson factors s...ensory neurons are lost before they can reachtheir target tissues. Ardem Patapoutian in Louis Reichardt's laboratory at the University ofCalifornia in San Fr...Better Binding Through Chemistry
... of the presentingprotein, making it appear to its target as if it is much bigger andstickier. "Using a pre...506 have nospecial affinity for calcineurin--their target protein in the human cell--untilthey bind to large presenting proteins. In fact, when one mixes cycl......s can then safely ferry therapeutic genes to their target tissues.)Using iron particles the same size as vir...may incorrectly assume that a drug is reaching its target in thebrain when in fact it is being stopped at the second barrier. ......and better outcomes. Medications and vitamins that target a particulargenetic susceptibility may be recommended to decrease disease occurrence. Forindividuals with susceptibility to breast, ovarian, endometrial or colon cancer,prophylactic surgery may reduce occurrence of these cancers. "Our patients are fa...Millennium Clones Diet-Induced Obesity Gene
...eceptor, the MG protein lends itself to serve as a target for drug development,noted Dr. Moore. Also, a sma...enomes should enable the useof the MG protein as a target for screens that test the function andeffectiveness of different compounds for possible human obesit...Whitehead Receives $7 million NIH Grant To Build High-Speed Sequencing Machines
...s for genomic sequencing. "The system will have a target hardware cost of $60,000 to 100,000 per unit,making it feasible to sequence an entire mammalian genome in a year with acapital investment of less than $2-3 million in sequencing apparatus," says Dr.Matsudaira. "The Whitehead Institute Group brings a...UB Researchers Identify Specific Oral Bacteria Most Likely To Increase Risk Of Heart Disease
... the findings are confirmed, it may be possible to target the bacteriawith antibiotics or vaccines and lower the risk of heart attack in persons withperiodontal disease, according to Robert J. Genco, D.D.S., Ph.D., chiefinvestigator on this and earlier studies on the connection between oral bacteriaand hear...Abgenix Reports Encouraging Preclinical Results With ABX-EGF In Cancer Research
.... Another member of the EGFr family, Her-2, is the target for a monoclonalantibody currently being marketed by Genentech, Inc. for treatment of breast cancer. With cancer cells, expression of EGFr is significantly increased, whichincreases growth stimuli and causes cells to divide abnormally. Consequently,......nal cellular communications, making it a promising target for potentialdrugs to control messages gone awry. (A clinical trial directed by other researchers is already testing a drug thatsuppresses the tyrosine kinase messenger in order to block cancerproliferation.) Lead author on the PNAS report is Kiyosh...Powerful Anti-AIDS Agent Found In Tears And In Urine Of Pregnant Women
...ility to invade immunecells. The ribonucleases may target viral RNA, possibly affecting viralreplication. The new study, published in the March 16 issue of The Proceedings of theNational Academy of Sciences, caps an intensive five-year search for thepowerful anti-AIDS and anti-cancer agent present in a......ures forthe creation of fibers or for transport of target molecules. In presentations at the 217th American ...pockets of aspecific size that can be used to trap target molecules, which can then betransported and released by reversing the construction of the dendrimer....Viral Harpoon Structure Suggests Measles, HIV And Ebola Viruses Related
...is launched into thegel-like outer membrane of the target cell. "It's much like a harpoon goinginto a target...efold itself to draw the virus toward the ensnared target cell?"What happens there is a mystery," he said. "It's like spearing ashark. It’s relatively ea...Vastly Different Virus Families May Be Related
...e two membranes tofuse is turning out to be a good target for inhibitors. There are some peptidesin clinical trials that will block HIV entry specifically by attaching to thisprotein." Lamb said that the goal would be to design small molecules that would makebetter drug candidates than peptides, which are l......tion alsoaffects managers' ability to achieve that target by creating uncertainty aboutthe abundance of fish present during a fishing season." He says the researchers will also use the grant to develop and testmethods for estimating in a timely manner changes in productivity of varioussalmon stocks...UCSF Lab Makes Observation That Could Explain Ability Of Modified Cold Virus To Kill Cancer Cells
...s function is proven, it could also serve as a new target for cancertherapies in some tumors lacking functional p53 genes.The ongoing research is funded by Onyx Pharmaceuticals, Inc. McCormick foundedthe company and is now on its scientific advisory board....