Discovering what genes do the high-throughput way
...anded RNA to each well. After three days, when the targeted gene should be inhibited, they stained the cells s...sets of double stranded RNA to each well, one that targeted the tumor suppressor gene pten and the other the gene to be tested, the researchers found that they ...Study offers genetic clues to causes of mysterious skin disease
...ls and genes involved also could lead to much more targeted treatment efforts, she said....Identifying cancer genes Will it really lead to better treatment?
...s for drug development, which could lead to better targeted or even individualised - treatment for cancer pat...n genetic mutation occurs. A small number of drugs targeted at mutated cancer genes have already been shown to act effectively. "Undoubtedly, these advances h...$8 million grant establishes program to uncover genetics of asthma
...ight then be applied to develop and test new drugs targeted to particular forms of asthma, for example those associated with exposure to allergens or environmental irritants such as ozone, said David A. Schwartz, M.D., chief of pulmonary medicine at Duke and principal investigator of the new program. The Nati...Collapse of seals, sea lions & sea otters in North Pacific triggered by overfishing of great whales
...nally sea otters (90's - today), the killer whales targeted populations of small, coastal marine mammals. The authors surmise that killer whales may have preferred harbor seals and fur seals to sea lions because of the higher nutritional value of harbor seals and because seals are less aggressive and easier ...National lab trains U. S. customs agents against WMD
...ining classes are modeled after a training program targeted to inspectors from other countries called INTERDICT/RADACAD, for Interdiction of Materials and Radiation Academy. The international program has been jointly conducted by PNNL and the former U.S. Customs Service under funding from multiple agencies, ...U of MN researchers find genetic variations may predict treatment responses for myeloma
...ore effective treatments and help to evaluate new, targeted therapies." Myeloma is a cancer of plasma cells, which are antibody-producing cells normally present in the bone marrow. More than 1,000 new cases or myeloma are diagnosed daily around the world making this the second most common form of blood cance...Battle of the DNA bulge may help thwart cancer
...lems." Ultimately, the UH studies may lead to more targeted cancer treatments, says Pettitt, who also is director of the Institute for Molecular Design at UH. Pettitt will present his research on DNA bulges and recognition proteins Sept. 7 at the 226th annual American Chemical Society national meeting in New ...Study at TSRI links dozens of proteins to several rare muscle and nerve degeneration diseases
...ns at random and demonstrated that they all indeed targeted to the nuclear membrane. The new nuclear membrane proteins identified in this study map to chromosomal regions where the following dystrophies have been localized: Congenital Ptosis, hereditary type 1 Charcot-Marie-Tooth Disease 2A Congenital M...... oxidemediated endothelial function in diabetes by targeted transgenic GTPcyclohydrolase I overexpression AUTHOR CONTACT: Keith Channon John Radcliffe Hospital, Oxford, United Kingdom Phone : 44-1865-851085 Fax : 44-1865-222077 E-mail: keith.channon@cardiov.ox.ac.uk View the PDF of this article at: https......racers can be attached to other molecules that are targeted to particular cells. For example, highly active cells, such as cancer cells, can be tagged with radioactive glucose. Non-invasive imaging technology such as PET allows researchers to gain more information and to use fewer animals in experimental stud...First production of a human protein with complex glycosylation in genetically modified yeast
... & II and UDP-N-acetylglucosamine transporter. The targeted localization of these enzymes enabled the generation of a synthetic in vivo glycosylation pathway that enabled the yeast to produce a complex human N-glycan, GlcNAc2Man3GlcNAc2, in vivo. However, unlike the glycosylation pathway in mammalian cell lin...Studies probe rapid evolution of Chinese tallow trees
... suggests that Chinese tallow trees in Georgia are targeted by indigenous insects. Siemann and Rogers think th...ld have the least insect defenses and therefore be targeted more often by insects in every region. Trees from each region should suffer higher damage in Georgia...Researchers identify genes that may be associated with prognosis in pediatric leukemia
... future will be able to use these genes to develop targeted treatment programs that will even better improve children's chances for cure from AML." Acute myeloid leukemia is a cancer of the blood-forming tissue, primarily the bone marrow and lymph nodes, and is divided into several subtypes. Early symptoms ...Zengen's new technology first to deliver drug active ingredients in an oral strip
...is in marketing well-known brands to consumers via targeted advertising and promotion as well as identifying and developing new innovative line extensions that better meet consumers' needs.......r activates ATR to block cell replication in cells targeted by the AIDS virus. Caffeine was used in the study because earlier research found that large concentrations of caffeine blocked the ability of chemotherapy drugs to prevent the division of cancer cells grown in the laboratory, and instead let the can...Small subset of cells has big role in controlling immunity, study finds
...dings take the researchers closer to their goal of targeted manipulation of the immune system. "In principal we can use the new immunosuppressive drug to do that. We can treat mice with the reagent, and introduce antigens that their immune systems would normally respond vigorously to. The prediction is that t...JCI Table of Contents, 15 August 2003
...arolina, show that allergen-sensitized mice with a targeted deletion of the gene encoding beta-arrestin-2 (a G proteincoupled receptor regulator) do not accumulate lymphocytes in their airways, nor do they demonstrate other physiological and inflammatory features characteristic of asthma. Because beta-arresti...The genetic complexities of sensation-seeking behavior in alcoholic men
...nce, we may one day be able to develop new, highly targeted drugs. Third, it may be well worth our while to examine the impact of specific treatments, such as cognitive behavioral techniques, on subgroups of alcohol-dependent patients who have particular personality traits." Limosin said he plans to continue...Monitoring malaria: Genomic activity of the parasite in human blood cells
...rs renewed hope for the design of inhibitory drugs targeted at the regulatory machinery that would irreparably foul the parasite's regulatory program, ultimately resulting in its death....