Researchers measure the 'heat of life,' offering clues to DNA damage
...rrect synthesis through the introduction of highly targeted external agents. "The only reason we are not a bunch of mutants walking around is that we have exquisite repair systems that can recognize these damaged sites and repair them before they replicate. And, if they do escape initial repair and replicat...Technique may identify novel disease genes at a faster clip
... is of great interest, said Darnell, because it is targeted by the immune system in the neurodegenerative disease, paraneoplastic opsoclonus myoclonus ataxia, which causes progressive loss of motor control. "Previous work in our laboratory had revealed how Nova bound to RNA, and we had identified a couple of ...Clock cells, tumor suicide, tailored therapies among subjects of AACR-NCI-EORTC Conference
... selection and barriers to the clinical testing of targeted agents will be debated by academic and pharmaceutical company scientists and federal regulators at two forums during the meeting. Leroy E. Hood, Co-founder and President of the Institute for Systems Biology and Affiliate Professor at the University ...Study of primitive life form expected to provide clues to biological processes in higher organisms
...ism. He also hopes to identify the processes first targeted for regulation in this manner, and learn how other organisms built upon this foundation to create complex information processing networks. The project will utilize a variety of approaches, including genomics, enzymology, molecular biology and mass s...Can viruses that infect bacteria fight plant disease?
...ic for their host bacterial species, and so can be targeted towards harmful bacteria while leaving other, potentially beneficial bacteria intact. Phage therapy has been used successfully against bacterial blotch of mushrooms caused by Pseudomonas tolaasii. In studies notable for the employment of phage host-r...Study offers new insight into Rett Syndrome
...ed by neuronal activity, many of which also may be targeted by MeCP2. "BDNF is probably not the key gene in Rett Syndrome," Jaenisch says. "More likely, it's one of many genes." The next step, says Greenberg, "is to identify other genes that are regulated by MeCP2," which he says now can be done on a genome...Fruits offer powerful protection from skin cancer
...is translocation leads to the transcription of Wnt targeted genes, such as c-myc, causing cancer. Skin cancer is the most common cancer, with more than 1.3 million new cases expected in 2003. Additionally, the American Cancer Society estimates that in 2003, there will be 54,200 new cases of melanoma, and abo...Gene-expression atlas will provide new direction for brain and spinal-cord studies
... GENSAT project will enable these strategies to be targeted to specific cells in a circuit, to better understand how that circuit operates and controls behavior." For researchers studying neurological disorders, the atlas will enable dissection of molecular mechanisms and neural circuitry underlying those dis...OHSU researchers discover molecular signaling system controlling aspects of embryonic development
... Identifying the players allows us to design drugs targeted at a precise molecular interaction. These types of drugs tend to have the maximum therapeutic impact with the fewest side effects," said Weiss. Previous independent studies had identified a cell-surface receptor protein called anaplastic lymphoma kin...New class of antibiotics stops pathogens in their genetic tracks
...inhibits a particular process, it's easier to make targeted drugs," Artsimovitch said. "In this case, finding ...lds great promise for designing drugs specifically targeted to major classes of bacterial pathogens, such as those that cause pneumonia and tuberculosis. "Whene...Saliva spits out information on chemical exposure
... The carbon nantotubes hold the enzymes, which are targeted to the organophosphate chemicals, and electricity is applied. If organophophates are present, there is a decrease in the electrical current that can be correlated to the amount of chemical present. The hand-held biosensor detection system will facili...UBC researcher discovers 'control room' that regulates immune responses
...implications for patients because treatment may be targeted by adjusting the "dial", says Jefferies. Immune responses may be increased to fight infection or reduced to help the body accept transplanted tissue or organs. The work was recently published online in Nature Immunology and will be the topic of an e...Fourteen Grand Challenges in Global Health announced
...olve them. By directing substantial and carefully targeted resources toward key health-related research questions pertinent to developing countries, the Grand Challenges initiative is intended to attract talented investigators to address these issues and significantly accelerate the development of affordable...'Timeless' gene found to play key role as timekeeper in mammals
... mammals but not to the clock. "The other labs had targeted their reagents at the end of the gene where changes in only full-length timeless are difficult to isolate due to the over-abundance of the short isoform," Jessica Barnes said. "So their results were being confounded." Working with the whole molecule,...JCI table of contents, 15 October, 2003
...ew York have identified monoclonal antibodies that targeted the histone H2B-like protein of H. capsulatum and reduced fungal burden, diminished inflammation, and prolonged host survival. While vaccine development for H. capsulatum is an exciting area of research, vaccination may not be effective in immunocomp...Building a better atlas of yeast proteins
...nes that specify each yeast protein. To create the targeted tags, they synthesized about 13,000 gene sequences that would target one of the tags to the end of each gene in the yeast genome. They used these specific tags to mark some 6,234 yeast gene segments, called "open reading frames." As a result of the g...New Columbia Genomic Center of Excellence aims to speed genetic targeting of medicines
...develop more effective, individualized genetically targeted treatments for a range of diseases. Neuronal diversity and plasticity will be a primary focus. WHEN: Thursday, October 16, 2003, 12:00 1:00 p.m. The briefing will take place during "Genes and Genomes: Impact on Medicine and Society," a far-ra...PNNL wins record $10.2 million NIH grant for proteomics center
...ated with specific diseases and can potentially be targeted by new drugs." What's more, "the ability to analyze the complex sets of very low level proteins in blood with much greater sensitivity along with the ability to analyze many samples, provides the basis for developing new biomarkers for the early dia...When heme attacks: After trauma, the molecule that makes life possible rampages
...researchers also identified a chemical that can be targeted by drug developers to impede the deleterious effects of free-floating heme. Following a traumatic event such as an accident, a stroke, a heart attack or even surgery heme floods the spaces between and inside cells and exacerbates the damage. It do...COX-2 inhibitors and renal damage in obesity-related Type II diabetes
...non-steroidal anti-inflammatory drugs (NSAIDS) are targeted to inhibit COX-2 and treat inflammation and arthritic pain. It is not known if the use of NSAIDS may be beneficial for the treatment of kidney disease; however, the upregulation of pro-inflammatory COX-2 and increased production of COX-2 derived meta...