International study findings link acne-like rash to effectiveness of new targeted cancer treatment
...eatments. It is also the first monoclonal antibody targeting EGFR to have gained marketing authorisation in Europe and is now being evaluated in first-line treatment of colorectal cancer, with promising results. Professor Van Cutsem said that the acne-like rash was also a side effect of other EGFR i...Belgian researchers explore revolutionary approach to angiogenesis
...chool in Brussels have turned the whole concept of targeting tumour blood vessels on its head. Instead of the conventional approach of trying to starve tumour cells of the blood supply they need to grow, they are doing the opposite opening up the tumour blood supply to allow better access for cancer drugs and...Cancer vaccine based on pathogenic listeria bacteria shows promise targeting metastases
...ins University to develop a listeria-based vaccine targeting pancreatic and ovarian cancers that express the Me...dImmune, Inc., to develop a listeria-based vaccine targeting the large number of tumors, including breast, prostate and melanoma, that overexpress the antigen Ep...UCI scientists successfully target key HIV protein; breakthrough may lead to new drug therapies
... "By proving small molecules can be effective for targeting Nef, we've shown how researchers can expand the fight against AIDS," said Weiss. The researchers reported their findings last week in the online edition of the Proceedings of the National Academy of Science. The print version of the research paper wi...Cannabis may help combat cancer-causing herpes viruses
...ely inhibits the spread of gamma herpes viruses by targeting a gene these viruses all share called ORF50. Dr. Medveczky emphasized that more studies are needed. "We have not evaluated the effect of THC in an animal model yet so we do not recommend people start using pot to prevent or treat cancers." In fact, ...'Smart antibiotics' may result from UCLA research
...acteriophage or bacteria use the same strategy for targeting mutations and speeding up evolution. "We're eager to determine how widespread it is; the more we look, the more we find it," Miller said. "And the more we study it, the more ingenious the mechanism appears to us." In the Nature paper, the team ...IBD (Crohn's, Colitis) 'joins' cancer, inflammatory diseases in associated blood vessel growth
...upregulated by bFGF and TNF- but not VEGF, and its targeting with a specific antibody (Vitaxin) induced marked HIMEC apoptosis. HIMEC migration was dose-dependently induced by both CD and UC mucosal extracts, and was significantly greater than that induced by control extracts, the researchers reported. As show...Images of 'tail' of protein needed for cell multiplication suggest anticancer drug targets
...se that researchers can develop new types of drugs targeting the tail or the workshop itself, turning off the unrestrained multiplication of cancer cells. The study also shows that a slight change in a structure common among many enzymes performing similar jobs can create a new enzyme with a unique activity. ...Final Alert: 16th EORTC NCI AACR Symposium
...cing monoclonal antibody results from early study targeting TRAIL R2 protein Lypcopene and vitamin E inhibits prostate tumours new laboratory results underpin epidemiological evidence patient trial now started International trial finds acne-type side effect predicts effectiveness of new targeted treatment...Diabodies act as guided missiles targeted to mammary tumor growth
...of native antibodies, can be used effectively as a targeting vehicle for radioimmunotherapy, said Gregory Adams, Ph.D., associate member of the Medical Science Division, Fox Chase Cancer Center, Philadelphia, Pa. Diabodies are genetically engineered dimeric proteins produced in E. coli bacteria that contain...Essential smell gene may provide key to new insect repellents
...mell The researchers used a technique called gene targeting to create a strain of fruit flies lacking the Or83b gene. The flies appeared to be normal, but they could not smell at all, either as larvae or as adults. The scientists tested the flies' sense of smell by three methods. First they placed larvae one...Scientists discover proteins involved in spread of HIV-1 infection
...gulating the MVB pathway, which is responsible for targeting a number of important cellular proteins for lysosomal destruction." The scientists focused their efforts on one of the proteins,VPS37B, and found that it binds to TSG101 through a conserved sequence of amino acids that is also present in all of th...University of Pittsburgh receives $10 million grant for head and neck cancer
... that interferes with apoptosis, or cell death. By targeting STAT signaling, the researchers hope to inhibit the progression of head and neck cancer. Albert DeLeo, Ph.D., professor of pathology, and Robert Ferris, M.D., Ph.D., assistant professor of otolaryngology, will head up an additional project to develo...Tiny molecules have big potential as cancer drugs, Stanford researcher believes
...Many cancer therapies take a "big stick" approach, targeting rapidly dividing cells in the body to stop malignancies in their tracks but often triggering horrible side effects in the process. New research from the Stanford University School of Medicine points toward the possibility of a different type of cance......entional food?" the title of a day-long symposium targeting consumer health and economics he has organized for the 228th American Chemical Society (ACS) National Meeting in Philadelphia on Monday, Aug. 23. "The truth is out there," says Rosen, a professor of food science at Rutgers, The State University of Ne...Researchers find clues about how antibodies specialize
...d to promote its interaction with RPA. "Such a targeting mechanism for AID is essential for our immune system," says Dr. Frederick W. Alt, a Howard Hughes Medical Institute researcher at the Children's Department of Molecular Medicine and senior investigator on the study. "Without it, we'd be immunodeficie...The first engineering of cell surfaces in living animals
...ll surfaces in living beings may someday allow the targeting of specific kinds of cells for noninvasive imaging, for developmental studies, and for treatment of disease. "There was no precedent for what we were trying to do, which was to modify the cells of a living animal so that they could undergo a chemica...Tips from the journals of the American Society for Microbiology
...ein with many cellular functions) and linked to E6 targeting HPV-associated lesions. Results showed a signific...ng, T.-C. Wu. 2004. Development of a DNA vaccine targeting human papillomavirus type 16 oncoprotein E6. Journal of Virology, 78. 16: 8468-8476.) New Antima...X marks the spot: Vector insertion is viral specific
...drugs against HIV. To that end, new information on targeting integration is likely to help guide design of better therapy, say the researchers. ...... source. "We were missing the boat because we were targeting the wrong cell," said Catriona Jamieson, MD, PhD, instructor in hematology and first author of the paper. Other researchers have found cancer stem cells in acute myelogenous leukemia, breast cancer and two types of brain cancer. The current work, pub...